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BMC Biology
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#2Anders BlombergH-Index: 59
Last.Joanna Y. WilsonH-Index: 20
view all 18 authors...
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#1Abhinav JoshiH-Index: 2
view all 14 authors...
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#1Kyerl Park (KU: Korea University)H-Index: 2
Last.Jeehyun Kwag (KU: Korea University)H-Index: 8
view all 6 authors...
Background Abnormal accumulation of amyloid β1–42 oligomers (AβO1–42), a hallmark of Alzheimer’s disease, impairs hippocampal theta-nested gamma oscillations and long-term potentiation (LTP) that are believed to underlie learning and memory. Parvalbumin-positive (PV) and somatostatin-positive (SST) interneurons are critically involved in theta-nested gamma oscillogenesis and LTP induction. However, how AβO1–42 affects PV and SST interneuron circuits is unclear. Through optogenetic manipulation o...
#1Sunjoo Joo (UBC: University of British Columbia)H-Index: 2
#2Ming Hsiu Wang (UBC: University of British Columbia)H-Index: 2
Last.Jae-Hyeok Lee (UBC: University of British Columbia)H-Index: 11
view all 9 authors...
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#1Heike RampeltH-Index: 13
Last.Nikolaus Pfanner (University of Freiburg)H-Index: 99
view all 10 authors...
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#2Sergey AganezovH-Index: 6
Last.Igor V. SharakhovH-Index: 24
view all 26 authors...
Background New sequencing technologies have lowered financial barriers to whole genome sequencing, but resulting assemblies are often fragmented and far from ‘finished’. Updating multi-scaffold drafts to chromosome-level status can be achieved through experimental mapping or re-sequencing efforts. Avoiding the costs associated with such approaches, comparative genomic analysis of gene order conservation (synteny) to predict scaffold neighbours (adjacencies) offers a potentially useful complement...
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#1Ace North (University of Oxford)H-Index: 9
#2Austin Burt (Imperial College London)H-Index: 52
Last.H. Charles J. Godfray (University of Oxford)H-Index: 55
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The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a driving-Y chromosome to suppress vector populations in a 106 km2 area of West Africa including all of Burkina Faso. The consequence of driving-Y introductions is predicted to vary across the lands...
10 CitationsSource
#1Antony P. Page (Glas.: University of Glasgow)H-Index: 23
#2Mark Roberts (Glas.: University of Glasgow)H-Index: 32
Last.William Weir (Glas.: University of Glasgow)H-Index: 22
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Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelmintic compounds, for which there is now widespread resistance being reported. There is a current unmet need to develop novel control measures including the identification and characterisation of natural pathogens of nematodes. Nematode killing bacilli were isolated from a rotten fruit in as...
1 CitationsSource
#1Esther A. Odekunle (QMUL: Queen Mary University of London)H-Index: 1
#2Dean C. Semmens (QMUL: Queen Mary University of London)H-Index: 7
Last.Maurice R. Elphick (QMUL: Queen Mary University of London)H-Index: 35
view all 13 authors...
Vasopressin/oxytocin (VP/OT)-type neuropeptides are well known for their roles as regulators of diuresis, reproductive physiology and social behaviour. However, our knowledge of their functions is largely based on findings from studies on vertebrates and selected protostomian invertebrates. Little is known about the roles of VP/OT-type neuropeptides in deuterostomian invertebrates, which are more closely related to vertebrates than protostomes. Here, we have identified and functionally character...
1 CitationsSource
#1Lucille Stuani (University of Toulouse)H-Index: 4
#2Marie Sabatier (University of Toulouse)H-Index: 1
Last.Jean-Emmanuel Sarry (University of Toulouse)H-Index: 6
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Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the importance of metabolism in cancer biology and how these changes might constitute an Achilles heel for cancer treatment. In this Review, we discuss the role of metabolic and mitochondrial pathways dysregulated in ...
1 CitationsSource
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