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#1Ace North (University of Oxford)H-Index: 9
#2Austin Burt (Imperial College London)H-Index: 52
Last.H. Charles J. Godfray (University of Oxford)H-Index: 55
view all 3 authors...
The persistence of malaria in large parts of sub-Saharan Africa has motivated the development of novel tools to complement existing control programmes, including gene-drive technologies to modify mosquito vector populations. Here, we use a stochastic simulation model to explore the potential of using a driving-Y chromosome to suppress vector populations in a 106 km2 area of West Africa including all of Burkina Faso. The consequence of driving-Y introductions is predicted to vary across the lands...
10 CitationsSource
#1Esther A. Odekunle (QMUL: Queen Mary University of London)H-Index: 1
#2Dean C. Semmens (QMUL: Queen Mary University of London)H-Index: 7
Last.Maurice R. Elphick (QMUL: Queen Mary University of London)H-Index: 35
view all 13 authors...
Vasopressin/oxytocin (VP/OT)-type neuropeptides are well known for their roles as regulators of diuresis, reproductive physiology and social behaviour. However, our knowledge of their functions is largely based on findings from studies on vertebrates and selected protostomian invertebrates. Little is known about the roles of VP/OT-type neuropeptides in deuterostomian invertebrates, which are more closely related to vertebrates than protostomes. Here, we have identified and functionally character...
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#1Antony P. Page (Glas.: University of Glasgow)H-Index: 23
#2Mark Roberts (Glas.: University of Glasgow)H-Index: 32
Last.William Weir (Glas.: University of Glasgow)H-Index: 22
view all 6 authors...
Nematodes represent important pathogens of humans and farmed animals and cause significant health and economic impacts. The control of nematodes is primarily carried out by applying a limited number of anthelmintic compounds, for which there is now widespread resistance being reported. There is a current unmet need to develop novel control measures including the identification and characterisation of natural pathogens of nematodes. Nematode killing bacilli were isolated from a rotten fruit in as...
1 CitationsSource
#1Lucille Stuani (University of Toulouse)H-Index: 4
#2Marie Sabatier (University of Toulouse)H-Index: 1
Last.Jean-Emmanuel Sarry (University of Toulouse)H-Index: 6
view all 3 authors...
Changes in cell metabolism and metabolic adaptation are hallmark features of many cancers, including leukemia, that support biological processes involved into tumor initiation, growth, and response to therapeutics. The discovery of mutations in key metabolic enzymes has highlighted the importance of metabolism in cancer biology and how these changes might constitute an Achilles heel for cancer treatment. In this Review, we discuss the role of metabolic and mitochondrial pathways dysregulated in ...
1 CitationsSource
#1Avinash S. Gaikwad (Monash University)H-Index: 1
#2Amanda L. Anderson (University of Newcastle)H-Index: 10
Last.Brett Nixon (University of Newcastle)H-Index: 36
view all 8 authors...
The sperm protein IZUMO1 (Izumo sperm-egg fusion 1) and its recently identified binding partner on the oolemma, IZUMO1R, are among the first ligand-receptor pairs shown to be essential for gamete recognition and adhesion. However, the IZUMO1-IZUMO1R interaction does not appear to be directly responsible for promoting the fusion of the gamete membranes, suggesting that this critical phase of the fertilization cascade requires the concerted action of alternative fusogenic machinery. It has therefo...
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#1Pundrik Jaiswal (NIH: National Institutes of Health)
#2Alan R. Kimmel (NIH: National Institutes of Health)H-Index: 47
Kinases mTORC1 and AMPK act as energy sensors, controlling nutrient responses and cellular growth. Changes in nutrient levels affect diverse transcriptional networks, making it challenging to identify downstream paths that regulate cellular growth or a switch to development via nutrient variation. The life cycle of Dictyostelium presents an excellent model to study the mTORC1 signaling function for growth and development. Dictyostelium grow as single cells in nutrient-rich media, but, upon nutri...
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#1Courtney W. Stairs (Uppsala University)H-Index: 13
#2Anna Kokla (SLU: Swedish University of Agricultural Sciences)H-Index: 1
Last.Thijs J. G. Ettema (Uppsala University)H-Index: 6
view all 6 authors...
Background Spironucleus salmonicida is an anaerobic parasite that can cause systemic infections in Atlantic salmon. Unlike other diplomonad parasites, such as the human pathogen Giardia intestinalis, Spironucleus species can infiltrate the blood stream of their hosts eventually colonizing organs, skin and gills. How this presumed anaerobe can persist and invade oxygenated tissues, despite having a strictly anaerobic metabolism, remains elusive.
1 CitationsSource
#1L. Basten Snoek (UU: Utrecht University)H-Index: 24
#2Rita J. M. Volkers (WUR: Wageningen University and Research Centre)H-Index: 11
Last.Jan E. Kammenga (WUR: Wageningen University and Research Centre)H-Index: 36
view all 14 authors...
The nematode Caenorhabditis elegans has been extensively used to explore the relationships between complex traits, genotypes, and environments. Complex traits can vary across different genotypes of a species, and the genetic regulators of trait variation can be mapped on the genome using quantitative trait locus (QTL) analysis of recombinant inbred lines (RILs) derived from genetically and phenotypically divergent parents. Most RILs have been derived from crossing two parents from globally dista...
4 CitationsSource
#1Lawrance Chandra (Iowa State University)H-Index: 2
#2Dana C. Borcherding (Iowa State University)H-Index: 1
Last.Karin Allenspach (Iowa State University)H-Index: 3
view all 21 authors...
Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiologic features with humans. To bridge the gap between commonly used animal models, such as rodents, and humans, and expand the translational potential of the dog model, we developed a three-dimensional (3D) canine GI organoid (enteroid and colonoid) system. Organoids have recently gained inte...
2 CitationsSource
#1Yuri Frosi (Agency for Science, Technology and Research)
#2Rachael Usher (Agency for Science, Technology and Research)
Last.Christopher J. Brown (Agency for Science, Technology and Research)H-Index: 21
view all 5 authors...
The most commonly occurring cancer mutations, including oncogenes such as MYC, Ras and PIK3C, are found in signal transductions pathways feeding into the translational machinery. A broad range of translation initiation factors are also commonly found to be either amplified or mis-regulated in tumours, including eIF4E (elongation initiation factor 4E). eIF4E is a subunit of the eIF4F protein initiation complex and required for its recruitment. Here we measure the formation of the eIF4F complex th...
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