Biomaterials Science
Papers 2014
1 page of 202 pages (2,014 results)
#2Wenying WeiH-Index: 1
Last. Honglian DaiH-Index: 11
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Unrestricted usage of antibiotics has accelerated the emergence of new strains of microorganism with antimicrobial resistance (AMR) and the development of therapeutic technologies which do not only rely on antibiotics. Herein, mesoporous hollow Fe3O4 nanoparticles (MHFPs) were synthesized by one-pot hydrothermal method and the feasibility and possible mechanism of using alternating magnetic field (AMF) with MHFPs to kill Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was explor...
#1Mengli DingH-Index: 1
#2Zhaohua MiaoH-Index: 10
Last. Zhong CaoH-Index: 12
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Catalytic nanomedicine with high oxygen-generation efficiency may find applications in alleviating the tumor hypoxia and improving the efficiency of photodynamic therapy (PDT). In this study, a catalytic nanosystem (Ce6-Rh@MPDA) was developed using mesoporous polydopamine nanoparticles (MPDA) to encapsulate the catalase-like rhodium nanoparticles (Rh NPs) and photosensitizer chlorin e6 (Ce6) for photoacoustic/fluorescence dual imaging-guided tumor therapy. The Rh NPs can catalyze the production ...
#1Dong ZhaiH-Index: 22
#2Lei ChenH-Index: 49
Last. Chengtie WuH-Index: 59
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Articular cartilage lesions occur frequently but unfortunately the damaged cartilage has a very limited intrinsic repair capacity. Since the cartilage damage can cause sterile inflammation, the effects of inflammation on cartilage repair should be well understood for precise treatment. Our previous study showed that bioceramics play an important role for cartilage regeneration. However, it is unclear how the immune microenvironment induced by bioactive ceramics influences the cartilage regenerat...
#1Guanyou LinH-Index: 3
#2Qingxin MuH-Index: 22
Last. Miqin ZhangH-Index: 66
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The ability to visualize and quantify apoptosis in vivo is critical to monitoring disease response to treatment and providing prognosis information. However, the application of current apoptosis labeling probes faces significant challenges including nonspecific tissue labeling, short monitoring windows, and low signal to noise ratios. Here we report a highly specific apoptosis labeling nanoparticle (NP) probe with pisum sativum agglutinin (PSA) as tumor targeting ligand for prolonged in vivo apo...
Cell sheets engineering received great attention because of the thin layers of tissue can be easily transplanted to defect sites. Wound dressing materials are required to support fast re-epithelization both with keratinocytes and fibroblasts to enhanced prognosis and therapeutic outcomes. We prepared self-assembled cell sheets composed of adipocyte derived stem cells (ADSCs) and surface-engineered nanofibrils (NF). NF was surface-engineered with multilayers of gelatin so that cell sheets could s...
#1Aruna Prasopthum (WU.: Walailak University)H-Index: 3
#2Zexing Deng (Xi'an Jiaotong University)
Last. Jing Yang (University of Nottingham)H-Index: 24
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Conductive polymers have been used for various biomedical applications including biosensors, tissue engineering and regenerative medicine. However, the poor processability and brittleness of these polymers hinder the fabrication of three-dimensional structures with desirable geometries. Moreover, their application in tissue engineering and regenerative medicine has been so far limited to excitable cells such as neurons and muscle cells. To enable their wider adoption in tissue engineering and re...
#1Hamed Nosrati (Zanjan University of Medical Sciences)H-Index: 14
#2Jalil Charmi (Zanjan University of Medical Sciences)
Last. Hossein Danafar (Zanjan University of Medical Sciences)H-Index: 23
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The goal of this work is to harness the advantages of a targeted hybrid nanostructure, BSA-coated Fe3O4 (F)-Au heterodimer, as a radiosensitizer and co-delivery vehicle of chemotherapeutic drugs for enhanced synergic cancer therapy and protection of healthy tissues. F-Au-BSA-MTX-CUR combines the abilities of enhanced X-ray radiation therapy (F-Au), long blood circulation time (BSA), tumor targeting (MTX), enhanced chemotherapy (MTX and CUR), and protection of normal cells against the harmful eff...
#1Hao SuH-Index: 41
#2Yonggang CuiH-Index: 2
Last. Honggang CuiH-Index: 42
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Therapeutic constructs with imaging modalities hold great promise for improving the treatment efficacy for cancer and many other diseases. We report here on the design and synthesis of a self-assembling prodrug (SAPD) by direct linkage of camptothecin (CPT), an anticancer drug, to a metal-chelating agent, DOTA. We found that under the physiological condition the DOTA-conjugated CPT prodrug can self-assemble into tubular supramolecular polymers (SPs) of several micrometers in length. Our studies ...
#1Xijian LiuH-Index: 20
#2Minyi ZhangH-Index: 2
Last. Jie LuH-Index: 18
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We herein explored a smart Fe-HPPy@Au/DOX theranostic agent to achieve CT diagnosis and PTT/chemotherapy/CDT synergistic treatment of cancer. When the Fe-HPPy@Au/DOX theranostic agent entered the tumor, the trapped Fe ion accelerated release to catalyze the production of •OH for CDT. NIR irradiation drove the PTT, at the same time improved the CDT by enhancing the •OH producing amounts and triggered the DOX release for chemotherapy. In addition, the Au nanoparticles on the surface of Fe-HPPy@Au ...
Early diagnosis and therapy of hepatocellular carcinoma (HCC) is critical to improve the five-year survival rates of patients. Nanotheranostic agents synergized with photothermal ablation are expected to realize the early detection and treatment of orthotopic HCC. However, conventional metallic NPs are limited by their potential bio-toxicity to surrounding normal organs. Recently, endogenous biological melanin pigments have been utilized to develop nanoplatforms due to their excellent biocompati...
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Organic chemistry
In vivo