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Medicinal Research Reviews
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#1Xiaoxiao Yang (GSU: Georgia State University)H-Index: 1
#1Xiaoxiao Yang (GSU: Georgia State University)
Last. Binghe Wang (GSU: Georgia State University)H-Index: 48
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Treating acute kidney injury (AKI) represents an important unmet medical need both in terms of the seriousness of this medical problem and the number of patients. There is also a large untapped market opportunity in treating AKI. Over the years, there has been much effort in search of therapeutics with minimal success. However, over the same time period, new understanding of the underlying pathobiology and molecular mechanisms of kidney injury have undoubtedly helped the search for new therapeut...
2 CitationsSource
#1Xinyang Zhou (PKU: Peking University)H-Index: 1
#2Shuhe Wang (PKU: Peking University)H-Index: 1
Last. Zhenjun Yang (PKU: Peking University)H-Index: 7
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With the rapid development of synthetic technology and biological technology, many nucleic acid-based drugs have entered the clinical trials. However, their inherent disabilities in actively and efficiently penetrating cell membranes still severely restrict their further application. The main drawback of cationic lipids, which have been widely used as nonviral vectors of nucleic acids, is their high cytotoxicity. A series of nucleoside-based or nucleotide-based nucleolipids have been reported in...
1 CitationsSource
#1Wei Jia (SHU: Shanghai University)H-Index: 54
#2Cynthia Rajani (U.H.: University of Hawaii at Manoa)H-Index: 8
Last. Houkai Li (SHU: Shanghai University)H-Index: 1
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Recent epidemiological and molecular studies have linked the disruption of cholesterol homeostasis to increased risk for developing Alzheimer's disease (AD). Emerging evidence also suggests that brain cholesterol accumulation contributes to the progression of hepatic encephalopathy (HE) via bile acid (BA)-mediated effects on the farnesoid X receptor. In this perspective paper, we reviewed several recently published studies that suggested a role for the gut microbiota transformation of BAs as a f...
1 CitationsSource
Infections caused by multidrug-resistant bacteria represent a significant and ever-increasing cause of morbidity and mortality. There is thus an urgent need to develop efficient and well-tolerated antibacterials targeting unique cellular processes. Numerous studies have led to the identification of new biological targets to fight bacterial resistance. Two-component signal transduction systems are widely employed by bacteria to translate external and cellular signals into a cellular response. The...
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#1Claudia Albertini (UNIBO: University of Bologna)H-Index: 1
#2Alessandra Salerno (UNIBO: University of Bologna)
Last. Maria Laura Bolognesi (UNIBO: University of Bologna)H-Index: 39
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The continued drug discovery failures in complex neurodegenerative diseases, including Alzheimer's disease (AD), has raised questions about the classical paradigm "one-drug, one-target, one-disease." In parallel, the ever-increasing awareness of the multiplicity of the underlying pathways has led to the affirmation of polypharmacological approaches. Polypharmacology, which broadly embodies the use of pharmaceutical agents acting on multiple targets, seems to be the best way to restore the comple...
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#1Feng Gao (Qilu University of Technology)H-Index: 1
#1Feng Gao (Qilu University of Technology)
Last. Jiaqi Xiao (Qilu University of Technology)
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The continuous emergency of drug-resistant cancers and the low specificity of anticancer agents have been the major challenges in the control and treatment of cancer, making an urgent need to develop novel anticancer agents with high efficacy. Chalcones, precursors of flavonoids and isoflavonoids, exhibit structural heterogeneity and can act on various drug targets. Chalcones which demonstrated potential in vitro and in vivo activity against both drug-susceptible and drug-resistant cancers, are ...
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#1Aimei Liu (HAU: Huazhong Agricultural University)H-Index: 5
#2Qinghua Wu (Yangtze University)H-Index: 19
Last. María-Aránzazu Martínez (Complutense University of Madrid)H-Index: 19
view all 9 authors...
The cancer mortality rate of hepatocellular carcinoma (HCC) is the second highest in the world and the therapeutic options are limited. The incidence of this deadly cancer is rising at an alarming rate because of the high degree of resistance to chemo- and radiotherapy, lack of proper, and adequate vaccination to hepatitis B, and lack of consciousness and knowledge about the disease itself and the lifestyle of the people. DNA methylation and DNA methylation-induced epigenetic alterations, due to...
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#1Avinash Kumar (Manipal University)H-Index: 3
#2Ekta Rathi (Manipal University)
Last. Suvarna G. Kini (Manipal University)H-Index: 9
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An understanding of the pathology of cervical cancer (CC) mediated by E6/E7 oncoproteins of high-risk human papillomavirus (HPV) was developed by late 80 seconds. But if we look at the present scenario, not a single drug could be developed to inhibit these oncoproteins and in turn, be used specifically for the treatment of CC. The readers are advised not to presume the "viability of E6 protein" as mentioned in the title relates to just druggability of E6. The viability aspect will cover almost e...
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#1Mohd Farhan (UM: University of Macau)H-Index: 6
#2Marta Silva (UM: University of Macau)
Last. Wenhua Zheng (UM: University of Macau)H-Index: 27
view all 10 authors...
Autophagy is a highly conserved intracellular degradation process that plays a crucial role in cell survival and stress reactions as well as in cancer development and metastasis. Autophagy process involves several steps including sequestration, fusion of autophagosomes with lysosomes and degradation. Forkhead box O (FOXO) transcription factors regulate the expression of genes involved in cellular metabolic activity and signaling pathways of cancer growth and metastasis. Recent evidence suggests ...
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#1Ge Yan (WHU: Wuhan University)H-Index: 1
#2Yunfu Wang (HUM: Hubei University of Medicine)H-Index: 3
Last. Zhiqiang Li (WHU: Wuhan University)H-Index: 5
view all 9 authors...
: Glioblastoma is the most aggressive primary brain tumor in adults. The prognosis of patients with primary glioblastoma treated with the current standard of care, tumor resection followed by radiation therapy and auxiliary temozolomide, remains poor. Integrative genomic analyses have identified essential core signaling pathways and frequent genetic aberrations, which provide potential drug targets for glioblastoma treatment. Drugs against these therapeutic targets have been developed rapidly in...
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