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Reproductive Biomedicine Online
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Don Leigh1
Estimated H-index: 1
(Calmette Hospital)
“Are we there yet?”- these are the words that many parents would have heard when taking children on some sort of trip. The journey began over 30 years ago when the first PGTs were done. It was simple back then- the answers required were generally simple (or at least straightforward) and you only went looking for directed answers. PGS was for chromosomes and PGD was for a gene(s)- and generally, never the two would meet. Early chromosome testing was based on FISH and the targets were polar bodies...
Izabel Bernicot5
Estimated H-index: 5
,
Z. Reda + -3 AuthorsT. Anahory6
Estimated H-index: 6
Introduction Despite the use of more precise techniques that indicates greater incidence, meiotic segregation of interchromosomal insertion has rarely been studied. Theoretically, the risk to have a child at term with malformation or mental retardation is high but there are no tools to determine this risk. We have investigated the Preimplantation genetic diagnosis (PGT) management of patients with interchromosomal insertion (IT) by fluorescent in situ hybridization (FISH) to obtain a better unde...
Kate Abel (Royal Women's Hospital), Martin Healey13
Estimated H-index: 13
(University of Melbourne)
+ -3 AuthorsBeverley Vollenhoven25
Estimated H-index: 25
(Monash University)
ABSTRACT Research question The aim was to determine whether the quality of transferred embryos has an impact on the rate of congenital malformations in IVF/ICSI-conceived babies. Design The retrospective cohort study involved 6637 pregnancies ≥20 weeks gestation from women who underwent embryo transfer with a single day 5 embryo at a private multisite IVF clinic between 2005 and 2015. Embryos were classified as good quality (n=5537) or poor quality (n=1100) based on an internal grading system of...
Introduction Transfer of the patient's 1st polar body (PB) to donor oocyte cytoplasm has proven to be an effective method to help patients with low ovarian reserve and poor response. This technique allows doubling the number of oocytes suitable for fertilization, while maintaining the biological relationship of patient with the future child. The use of transfer in our practice has shown the ability of modified oocytes to form high morphological quality blastocysts and their euploidy have been ev...
Introduction Modern PGT-A methods make it possible to identify mixes of aneuploid and euploid cells in trophectoderm biopsies. In such instances the source embryos are classified as mosaic. IVF clinics must decide whether those samples should be considered for transfer. Different groups have published their observations on mosaic embryo transfers. We provide a comprehensive review of those reports and perform a combined evaluation of the data with the goal of achieving a higher-powered analysis....
Published on Mar 1, 2019in Reproductive Biomedicine Online2.93
Tingting Sha1
Estimated H-index: 1
(CSU: Central South University),
Xiaojuan Wang + 1 AuthorsYan Yan1
Estimated H-index: 1
(CSU: Central South University)
Abstract This meta-analysis was to study whether pregnancy-related outcomes and complications differ between polycystic ovary syndrome (PCOS) patients and other causes of infertility patients after underdoing in vitro fertilization (IVF). A systematic search of PubMed, Embase, the Cochrane Library and Chinese databases was carried out to identify relevant studies published before July 2018. Outcomes were expressed using the odds ratios (OR) and 95% confidence intervals (CIs). Subgroup analyses a...
Published on Apr 1, 2019in Reproductive Biomedicine Online2.93
Raquel Mendoza-Tesarik3
Estimated H-index: 3
,
Nicolás Mendoza13
Estimated H-index: 13
+ 1 AuthorsJan Tesarik57
Estimated H-index: 57
Abstract Research question This study aimed to identify women with IVF failure associated with low serum progesterone levels after embryo transfer in HCG-triggered cycles and to evaluate the effects of gonadotrophin-releasing hormone (GnRH) agonist, administered after embryo transfer, on serum progesterone and pregnancy outcomes in these cases. Design Fifty women who failed to achieve an ongoing clinical pregnancy and had abnormally low luteal-phase serum progesterone concentrations in their fir...
S. Lu , S. Yaox + -3 AuthorsCatherine Racowsky39
Estimated H-index: 39
(Harvard University)
Introduction For investigating the detection success rate and accuracy of non-invasive capacity screening(NICS) and determining its effectiveness on improvement of embryo transfer, we reviewed the research results and clinical advances of MALBAC-based NICS from multiple groups worldwide between 2016 to 2018. Material and Methods 1. Detection success rate: qPCR was used to investigate the starting DNA amount limit and the detection success rate of NICS in 1483 culture medium samples. 2. Detection...
Chun‐Hua Liao (NTU: National Taiwan University), M.Y. Chang (Boston Children's Hospital)+ -3 AuthorsChi-Chao Chao20
Estimated H-index: 20
(NTU: National Taiwan University)
Introduction Preimplantation genetic diagnosis (PGD) has become a crucial approach to help carriers of inherited disorders give birth to healthy offspring. Here, we review the PGD methodologies and explore the use of polymerase chain reaction (PCR)-based technologies for PGD in neurodegenerative diseases that are clinically relevant and have typical features such as late-onset and severely debilitating. Material and Methods Trophectoderm biopsies were performed at Day5/6 blastocyst stage. PGD us...
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