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Clinical Science
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#1Corey S. Moran (JCU: James Cook University)H-Index: 18
#2Sai Wang Seto (USYD: University of Sydney)H-Index: 19
Last. Jonathan Golledge (JCU: James Cook University)H-Index: 48
view all 8 authors...
Abdominal aortic aneurysm (AAA) is an important cause of mortality in older adults. Chronic inflammation and excessive matrix remodelling are considered important in AAA pathogenesis. Kinins are bioactive peptides important in regulating inflammation. Stimulation of the kinin B2 receptor has been previously reported to promote AAA development and rupture in a mouse model. The endogenous B2 receptor agonist, bradykinin, is generated from the kallikrein-kinin system following activation of plasma ...
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#1Daniel F. Arruda-Junior (USP: University of São Paulo)H-Index: 4
#2F. Martins (USP: University of São Paulo)H-Index: 3
Last. Luís Henrique Wolff Gowdak (USP: University of São Paulo)H-Index: 16
view all 13 authors...
The relationship between disturbances in glucose homeostasis and heart failure (HF) progression is bidirectional. However, the mechanisms by which HF intrinsically impairs glucose homeostasis remain unknown. The present study tested the hypothesis that the bioavailability of intact glucagon-like peptide-1 (GLP-1) is affected in HF, possibly contributing to disturbed glucose homeostasis. Serum concentrations of total and intact GLP-1 and insulin were measured after an overnight fast and 15 min af...
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#1Asoka Banno (University of Pittsburgh)H-Index: 3
#2Aravind T. Reddy (University of Pittsburgh)H-Index: 10
Last. Raju C. Reddy (University of Pittsburgh)H-Index: 11
view all 4 authors...
Asthma is a chronic disease of the airways that has long been viewed predominately as an inflammatory condition. Accordingly, current therapeutic interventions focus primarily on resolving inflammation. However, the mainstay of asthma therapy neither fully improves lung function nor prevents disease exacerbations, suggesting involvement of other factors. An emerging concept now holds that airway remodeling, another major pathological feature of asthma, is as important as inflammation in asthma p...
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#1J. Chen (Fourth Military Medical University)H-Index: 3
#2Tongtian Zhuang (Fourth Military Medical University)
Last. Ling Liu (Fourth Military Medical University)H-Index: 12
view all 15 authors...
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#1Médea Padra (University of Gothenburg)H-Index: 4
#2Anders Andersson (University of Gothenburg)H-Index: 4
Last. Shigemi Yoshihara (Dokkyo Medical University)H-Index: 8
view all 17 authors...
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#1Mathias D.G. Van den Eynde (Maastricht University Medical Centre)
#2Lukas Streese (University of Basel)H-Index: 3
Last. Henner Hanssen (University of Basel)H-Index: 17
view all 8 authors...
BACKGROUND: Advanced glycation endproducts (AGEs) are protein modifications that are predominantly formed from dicarbonyl compounds that arise from glucose and lipid metabolism. AGEs and sedentary behavior have been identified as a driver of accelerated (vascular) aging. The effect of physical activity on AGE accumulation is unknown. Therefore, we investigated whether plasma AGEs and dicarbonyl levels are different across older individuals that were active or sedentary and whether plasma AGEs ar...
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#1Amy C. Kelly (Anschutz Medical Campus)
#2Theresa L. Powell (Anschutz Medical Campus)H-Index: 50
Last. Thomas Jansson (Anschutz Medical Campus)H-Index: 48
view all 3 authors...
Maternal obesity is associated with pregnancy complications and increases the risk for the infant to develop obesity, diabetes and cardiovascular disease later in life. However, the mechanisms linking the maternal obesogenic environment to adverse short- and long-term outcomes remain poorly understood. As compared with pregnant women with normal BMI, women entering pregnancy obese have more pronounced insulin resistance, higher circulating plasma insulin, leptin, IGF-1, lipids and possibly proin...
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#1Jianxiang Xue (USF: University of South Florida)H-Index: 1
#2Linto Thomas (USF: University of South Florida)H-Index: 1
Last. Timo Rieg (USF: University of South Florida)H-Index: 31
view all 7 authors...
The sodium-hydrogen exchanger isoform 3 (NHE3, SLC9A3) is abundantly expressed in the gastrointestinal tract and is proposed to play essential roles in Na+ and fluid absorption as well as acid-base homeostasis. Mutations in the SLC9A3 gene can cause congenital sodium diarrhea (CSD). However, understanding the precise role of intestinal NHE3 has been severely hampered due to the lack of a suitable animal model. To navigate this problem and better understand the role of intestinal NHE3 we generate...
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#1Francesco Mannavola (University of Bari)H-Index: 7
#2Gaetano Pezzicoli (University of Bari)
Last. Marco Tucci (University of Bari)H-Index: 26
view all 3 authors...
Exosomes (Exo) have emerged as potent amplifiers of pro-tumorigenic signals to distant cells. The knowledge of their role in colorectal cancer (CRC) is continuously up-growing, although their contribution to metastasis remains largely unclear. Liu et al. (Clinical Science (2020) 134, https://doi.org/10.1042/CS20191087) in their work have described a novel mechanism by which CRC-derived Exo promote metastasis through the down-regulation of the deleted in liver cancer-1 (DLC-1), a gene involved in...
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#1Marianna Santopaolo (UoB: University of Bristol)H-Index: 1
#2Yue Gu (UoB: University of Bristol)
Last. Paolo Madeddu (UoB: University of Bristol)H-Index: 50
view all 4 authors...
Global trends in the prevalence of overweight and obesity put the adipocyte in the focus of huge medical interest. This review highlights a new topic in adipose tissue biology, namely the emerging pathogenic role of fat accumulation in bone marrow (BM). Specifically, we summarize current knowledge about the origin and function of BM adipose tissue (BMAT), provide evidence for the association of excess BMAT with diabetes and related cardiovascular complications, and discuss potential therapeutic ...
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Endocrinology
Cardiology
Diabetes mellitus
Medicine
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