Thrombosis and Haemostasis
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OBJECTIVE: The aim of the study is to perform a systematic review on the recent available evidence on antiphosphatidylserine/prothrombin (aPS/PT) antibodies and their association with clinical manifestations of the antiphospholipid syndrome (APS). METHODS: A detailed literature search was applied a priori to Ovid MEDLINE, In-Process and Other Non-Indexed Citation 2012 to present and to abstract from EULAR and ACR/ARHP Annual Meetings (2012-2019). RESULTS: Data from 2,901 patients, 587 diseases c...
#1Gili Kenet (Sheba Medical Center)H-Index: 31
#2Hervé Chambost (AMU: Aix-Marseille University)H-Index: 19
Last. Elena Santagostino (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)H-Index: 48
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INTRODUCTION: A phase 3b extension study evaluated the long-term safety and efficacy of a recombinant fusion protein-linking coagulation factor IX (FIX) with albumin (rIX-FP) for the routine prophylaxis and on-demand treatment of bleeding in pediatric hemophilia B patients. METHODS: Previously treated patients aged 7.2 IU/dL. No patient developed an inhibitor. CONCLUSION: This extension study demonstrated the long-term safety and efficacy of weekly rIX-FP in pediatric patients. Additionally, it ...
#1Mercedes López-Zambrano (University of Giessen)
#2Julian Rodriguez-Montesinos (University of Giessen)H-Index: 2
Last. Klaus T. Preissner (Kazan: Kazan Federal University)H-Index: 65
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Despite strong evidence supporting the cellular interplay between haemostasis and innate immunity, humoral connections between blood coagulation and the behavior of inflammatory macrophages are not well understood. In this study, we investigated changes in gene expression of selected cytokines and chemokines and their secretion profiles following thrombin stimulation of murine macrophages. Thrombin promoted differentiation of macrophages into an M1-like phenotype that was associated with the exp...
Transplant-associated thrombotic microangiopathy (TA-TMA) is a life-threatening complication of allogeneic hematopoietic cell transplantation (HCT). We hypothesized that pretransplant genetic susceptibility is evident in adult TA-TMA and further investigated the association of TMA-associated variants with clinical outcomes. We studied 40 patients with TA-TMA, donors of 18 patients and 40 control non-TMA HCT recipients, without significant differences in transplant characteristics. Genomic DNA fr...
#1Julia Tilburg (LUMC: Leiden University Medical Center)H-Index: 1
#2Sarah A. Michaud (UVic: University of Victoria)H-Index: 2
Last. Yassene Mohammed (UVic: University of Victoria)H-Index: 10
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The plasma compartment of the blood holds important information on the risk to develop cardiovascular diseases such as venous thrombosis (VT). Mass spectrometry-based targeted proteomics with internal standards quantifies proteins in multiplex allowing generation of signatures associated with a disease or a condition. Here, to demonstrate the method, we investigate the plasma protein signatures in mice following the onset of VT, which was induced by RNA interference targeting the natural anticoa...
1 CitationsSource
#1Nina Borràs (Autonomous University of Barcelona)H-Index: 3
#2Iris Garcia-Martínez (Autonomous University of Barcelona)H-Index: 9
Last. Ana Rosa Cid (IPN: Instituto Politécnico Nacional)H-Index: 16
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The clinical diagnosis of von Willebrand disease (VWD), particularly type 1, can be complex because several genetic and environmental factors affect von Willebrand factor (VWF) plasma levels. An estimated 60% of the phenotypic variation is attributable to hereditary factors, with the ABO blood group locus being the most influential. However, recent studies provide strong evidence that nonsynonymous single nucleotide variants (SNVs) contribute to VWF and factor VIII phenotypic variability in heal...
#1Tze-Fan Chao (NYMU: National Yang-Ming University)H-Index: 31
#2Yutao Guo (Chinese PLA General Hospital)
#1Anna Ruiz-Llobet (University of Barcelona)H-Index: 1
#2Ignacio Isola (University of Barcelona)H-Index: 4
Last. Rubén Berrueco (University of Barcelona)H-Index: 4
view all 8 authors...
INTRODUCTION: An underlying thrombocytopathy seems to be responsible for hemorrhagic symptoms in patients diagnosed with 22q11.2 deletion syndrome (22q11DS) or Noonan syndrome (NS). In 22q11DS, it is explained by a defect in the membrane glycoprotein (GP) complex Ib-V-IX. The cause of thrombocytopathy in NS remains unclear. AIM: The objective is to study the incidence of thrombocytopathy in pediatric patients diagnosed with 22q11DS or NS assessing the utility of ISTH-BAT questionnaire and labora...
#1Marco Proietti (University of Liverpool)
#2Deirdre A. Lane (University of Liverpool)H-Index: 59
#1Trond Børvik (UNN: University Hospital of North Norway)H-Index: 5
#2Sigrid K. Brækkan (UNN: University Hospital of North Norway)H-Index: 21
Last. John-Bjarne Hansen (UNN: University Hospital of North Norway)H-Index: 80
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Background Previous studies have shown increased mortality in venous thromboembolism (VTE) patients with chronic obstructive pulmonary disease (COPD), but it is unknown to what extent the association is influenced by the severity of COPD and physical inactivity. Objectives This article investigates whether COPD, and stages of COPD, influenced the risk of mortality after a first episode of VTE when physical inactivity was taken into account. Methods Patients with a first lifetime VTE (n = 256) we...
1 CitationsSource
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