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Clinical & Developmental Immunology
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#1Camila F. Oliveira-Toré (UFPR: Federal University of Paraná)
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Introduction. Ankylosing spondylitis (AS) and psoriatic arthritis (PsA) are classified as spondyloarthritis (SpA), a group of inflammatory rheumatic diseases with complex genetic etiology. Toll-like receptors (TLRs) have an important role in the mechanism of innate immunity and may influence inflammatory responses. Polymorphisms in TLR genes that lead to changes in these receptors or that interfere with the transcription rates of mRNA TLR may be involved in the chronic inflammatory immune respon...
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Inhalation of diesel exhaust particulate (DEP) causes oxidative stress-induced lung inflammation. This study investigated the protective effects of TF-343, an antioxidant and anti-inflammatory agent, in mouse and cellular models of DEP-induced lung inflammation as well as the underlying molecular mechanisms. Mice were intratracheally instilled with DEP or vehicle (0.05% Tween 80 in saline). TF-343 was orally administered for 3 weeks. Cell counts and histological analysis of lung tissue showed th...
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#2Sumaia A. Ali (Sudan University of Science and Technology)H-Index: 1
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Background. Small ruminant morbillivirus or peste des petits ruminants virus (PPRV) is an acute and highly contagious viral disease of goats, sheep, and other livestock. This study aimed at predicting an effective multiepitope vaccine against PPRV from the immunogenic proteins haemagglutinin (H), matrix (M), fusion (F), and nucleoprotein (N) using immunoinformatics tools. Materials and Methods. The sequences of the immunogenic proteins were retrieved from GenBank of the National Center for Biote...
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#1Benjamin Frempah (University of Oklahoma Health Sciences Center)H-Index: 1
#2Lerin R. Luckett-Chastain (University of Oklahoma Health Sciences Center)H-Index: 3
Last.Randle M. Gallucci (University of Oklahoma Health Sciences Center)H-Index: 14
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Irritant Contact Dermatitis (ICD) is characterized by epidermal hyperplasia and inflammatory cytokine release. IL-6 has been shown to be involved in the pathogenesis of ICD; however, the involvement of the IL-22/IL-22Rα axis and its relation to IL-6 in the inflammatory response following irritant exposure are unknown. Using a chemical model of ICD, it was observed that mice with a keratinocyte-specific knockout of IL-6Rα (IL-6RαΔker) presented with increased inflammation and IL-22Rα and IL-22 pr...
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#1Huihui XuH-Index: 3
#2Meijie LiuH-Index: 7
Last.Hongyan ZhaoH-Index: 9
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The human gut-resident commensal microbiota is a unique ecosystem associated with various bodily functions, especially immunity. Gut microbiota dysbiosis plays a crucial role in autoimmune disease pathogenesis as well as in bowel-related diseases. However, the role of the gut microbiota, which causes or influences systemic immunity in autoimmune diseases, remains elusive. Aryl hydrocarbon receptor, a ligand-activated transcription factor, is a master moderator of host-microbiota interactions bec...
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#1Nalin Lai (Shanxi Medical University)
#2Sheng-Xiao Zhang (Shanxi Medical University)H-Index: 2
Last.Xiaofeng Li (Shanxi Medical University)H-Index: 3
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Objective. Accumulating evidence indicates that regulatory T cells (Tregs) may be involved in the pathogenesis of ankylosing spondylitis (AS). As different markers have been used to identify Tregs, some studies on the proportions of Tregs in AS patients have generated considerable controversy. To clarify the status of Tregs in such patients, we determine the proportion changes of peripheral Tregs during development of the disease, with different cellular markers. Methods. We systematically searc...
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#1Michał Zych (Medical University of Warsaw)
#2Aleksander Roszczyk (Medical University of Warsaw)
Last.Radoslaw Zagozdzon (Medical University of Warsaw)H-Index: 19
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The aim of our study was to determine whether sildenafil citrate influences the production of Th1- (TNF-α, INF-γ) or Th2-type (TGF-β, IL-10) cytokines by lymphocytes of healthy men. Sildenafil citrate (SC) is a selective blocker of phosphodiesterase 5, by competing for the binding site with cGMP. It was reported that a higher risk of sexually transmitted diseases (STD) could be correlated with a recreational use of sildenafil, especially when combined with another drug. While behavioral causes o...
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#1Fujing Wang (JLU: Jilin University)
#2Yanhui Li (JLU: Jilin University)
Last.Haichun Ma (JLU: Jilin University)
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Anesthetics have long been proven to have additional effects other than anesthesia on different organs and tissues of the human body. Barrier tissues play critical roles in human health and diseases, yet the impacts of anesthetics on barrier tissues are still not clear. This review article is aimed at summarizing different effects of anesthetics on the skin, the respiratory, and intestinal membranes from two aspects: inflammation/immunity and ischemia-reperfusion. Among volatile, intravenous, an...
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#1Ning Wu (HUST: Huazhong University of Science and Technology)
#2Erwei Sun (Southern Medical University)
Last.Di Yu (ANU: Australian National University)
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#1Yu-ting He (Nanjing Medical University)
#2Ying Zhou (Nanjing Medical University)H-Index: 1
Last.Man Tian (Nanjing Medical University)H-Index: 3
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Objective. Asthma is a syndrome that incorporates many immune phenotypes. The immunologic effects of subcutaneous immunotherapy (SCIT) exerts on allergic asthma remain still largely unknown. Here, we investigated the effects of SCIT on cytokine production and peripheral blood levels of lymphocyte subtypes in children with mite-induced moderate and severe allergic asthma. Methods. The study included 60 kids with mite-induced allergic asthma from 5 to 10 years old. All subjects had received antias...
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