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The International Journal of Neuropsychopharmacology
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4.21
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2972
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#1Suhas Ganesh (Yale University)H-Index: 1
#2Jose Cortes-Briones (Yale University)H-Index: 10
Last. Deepak Cyril D'Souza (Yale University)H-Index: 35
view all 6 authors...
INTRODUCTION: There is increasing interest in the relationship between cannabinoids and psychosis. While individual human laboratory studies have been critical in demonstrating that cannabinoids (e.g., delta-9-tetrahydrocannabinol [THC]) can induce acute transient psychosis-like effects in healthy human volunteers, combining data from multiple studies offers a fine-grained view of these effects. METHODS: THC-induced psychosis-relevant effects were examined using a data-repository of 10 double-bl...
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#1Gang Xiao (UIUC: University of Illinois at Urbana–Champaign)
#2Daniel A. Llano (UIUC: University of Illinois at Urbana–Champaign)H-Index: 21
In this issue, Wang and colleagues solve an important puzzle in the understanding of schizophrenia. Previous work has linked NMDA receptor hypofunction to schizophrenia and shown that individuals with schizophrenia have a suppressed steady-state cortical response to 40-Hz repetitive auditory stimulation. However, systemic application of NMDA antagonists paradoxically increases this cortical response in rodents. Here, by specifically applying NMDA receptor blockade in the auditory thalamus while ...
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#1Ziad Saad (Janssen Pharmaceutica)H-Index: 1
#2Derrek P. Hibar (Genentech)H-Index: 37
Last. Guang Chen (Janssen Pharmaceutica)H-Index: 2
view all 9 authors...
BACKGROUND: At ketamine and esketamine doses at which antidepressant doses are achieved, these agents are relatively selective, non-competitive, NMDAR antagonists. However, at substantially higher doses, ketamine has shown mu-opioid receptor (MOR-gene symbol:OPRM1) agonist effects Preliminary clinical studies showed conflicting results on whether naltrexone, a MOR antagonist, blocks the antidepressant action of ketamine. We examined drug-induced or endogenous MOR involvement in the antidepressan...
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#1Bill Qi (McGill University)
#2Laura M. Fiori (Douglas Mental Health University Institute)H-Index: 16
Last. Yannis Trakadis (McGill University)H-Index: 6
view all 4 authors...
BACKGROUND: There is a lack of reliable biomarkers for Major depressive disorder (MDD) in clinical practice. However, several studies have shown an association between alterations in microRNA levels and MDD, albeit none of them has taken advantage of machine learning (ML). METHOD: Supervised and unsupervised ML were applied to blood microRNA expression profiles from a MDD case-control dataset (n=168) to distinguish between 1) case vs. control status, 2) MDD severity levels defined based on the M...
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#1Konstantinos N. Fountoulakis (A.U.Th.: Aristotle University of Thessaloniki)H-Index: 41
#2Lakshmi N. Yatham (UBC: University of British Columbia)H-Index: 62
Last. Hans Jurgen Moeller (LMU: Ludwig Maximilian University of Munich)H-Index: 4
view all 9 authors...
INTRODUCTION: Resistant Bipolar disorder (BD) is a major mental health problem related to significant disability and overall cost. The aim of the current study was to perform a systematic review of the literature concerning a) the definition of treatment resistance in BD, b) its clinical and c) neurobiological correlates, and d) the evidence-based treatment options for treatment resistant BD and eventually to develop guidelines for the treatment of this condition. MATERIAL AND METHODS: The PRISM...
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#1Qinyu Lv (SJTU: Shanghai Jiao Tong University)H-Index: 3
#2Qiongyue HuH-Index: 1
Last. Zhang Chen (SJTU: Shanghai Jiao Tong University)
view all 13 authors...
OBJECTIVE: Electroconvulsive therapy (ECT) is an effective option for treatment-resistant bipolar disorder (trBD). However, the mechanisms of its effect are obscure. Oxidative stress (OxS) is thought to be involved in the underpinnings of BD. Our study first to report the association between notable OxS parameters (superoxide dismutase, SOD; glutathione peroxidase; GSH-Px, catalase; CAT, and malondialdehyde, MDA) levels and ECT response in trBD patients. METHODS: Total 28 trBD patients and 49 co...
1 CitationsSource
BACKGROUND: Stimulant use and sexual behaviors have been linked in behavioral and epidemiological studies. Although methamphetamine-related neurofunctional differences have been investigated, few studies have examined neural responses to drug and sexual cues with respect to shorter or longer term methamphetamine abstinence in individuals with methamphetamine dependence. METHODS: Forty-nine men with shorter term methamphetamine abstinence, 50 men with longer term methamphetamine abstinence, and 4...
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#1Jing Sun (CAS: Chinese Academy of Sciences)
#2Jianbang Lin (CAS: Chinese Academy of Sciences)
Last. Shiyuan Xu (Southern Medical University)
view all 11 authors...
BACKGROUND: Both the clinical and pre-clinical studies have suggested embryonic or infant exposure to ketamine, a general anaesthetic, pose a great threat to the developing brain. However, it remains unclear about how ketamine may contribute to the brain dysfunctions. METHODS: Mouse model of prenatal exposure to ketamine was generated by intramuscular injection and continuous intraperitoneal infusion of pregnant mice. Open Field Test (OFT) and Elevated Plus Maze Test (EPM) were used to analyze t...
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#1Raffaella CalatiH-Index: 28
#2Charles B. Nemeroff (University of Texas at Austin)H-Index: 137
Last. Igor I. Galynker (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 27
view all 5 authors...
BACKGROUND: There has been increasing interest in both suicide-specific diagnoses within the psychiatric nomenclature and related biomarkers. Because the Suicide Crisis Syndrome-an emotional crescendo of several interrelated symptoms-seems to be promising for the identification of individuals at risk of suicide, the aim of the present paper is to review the putative biological underpinnings of the Suicide Crisis Syndrome symptoms (entrapment, affective disturbance, loss of cognitive control, hyp...
1 CitationsSource
#1Michel Nijs (Janssen Pharmaceutica)H-Index: 1
#2Ewa Wajs (Janssen Pharmaceutica)H-Index: 8
Last. Frank Wiegand (Janssen Pharmaceutica)H-Index: 5
view all 10 authors...
BACKGROUND: Esketamine nasal spray was recently approved for treatment-resistant depression (TRD). The current analysis evaluated the impact of symptom-based treatment frequency changes during esketamine treatment on clinical outcomes. METHODS: This is a post-hoc analysis of an open-label, long-term (up to 1 year) study of esketamine in patients with TRD (SUSTAIN 2). During a 4-week Induction phase, 778 patients self-administered esketamine twice-weekly plus a new oral antidepressant daily. In r...
1 CitationsSource
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