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European Respiratory Journal
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#1Constance de Margerie-Mellon (University of Paris)H-Index: 8
#2Lisa Belin (University of Paris)H-Index: 9
Last.Pierre-Yves Brillet (University of Paris)H-Index: 20
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The Fleischner Society White Paper and the ATS/ERS/JRS/ALAT guidelines recently redefined the computed tomography (CT) scanning patterns of usual interstitial pneumonia (UIP) [1,2]. Both publications confirmed honeycombing as the cornerstone of UIP pattern diagnosis, and introduced peripheral traction bronchiolectasis (PTB) as a key feature of the new “probable UIP” category. Therefore, improving the distinction between these two features may be critical, especially when the clinical likelihood ...
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#1Camila M. Costa (UNIFESP: Federal University of São Paulo)
#2J. Alberto Neder (Kingston General Hospital)H-Index: 22
Last.Jaquelina Sonoe Ota-Arakaki (UNIFESP: Federal University of São Paulo)H-Index: 11
view all 10 authors...
The prevailing view is that exertional dyspnoea in patients with combined idiopathic pulmonary fibrosis (IPF) and emphysema (CPFE) can be largely explained by severe hypoxemia. There is little evidence, however, to support these assumptions. We prospectively contrasted the sensory and physiological responses to exercise in 42 CPFE and 16 IPF patients matched by the severity of exertional hypoxemia. Emphysema and PF were quantified by computed tomography. Inspiratory constraints were assessed in ...
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#1Vanessa Martelli (U of T: University of Toronto)H-Index: 1
#2Jenna Sykes (St. Michael's Hospital)H-Index: 25
Last.Anne L. Stephenson (U of T: University of Toronto)H-Index: 24
view all 7 authors...
National cystic fibrosis (CF) data registries track patient characteristics over time and have provided insight into both emerging trends and current clinical needs. In a recent study, Burgel et al . utilised the flow method, a demographic model that predicts future trends in populations, and forecasted a 50% increase in the Western European CF population by 2025, with the adult population experiencing the largest increase [1]. Burgel et al . subsequently used the French registry to validate sho...
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#1Marilyne LévyH-Index: 19
#2Despina MoshousH-Index: 38
Last.Damien BonnetH-Index: 64
view all 11 authors...
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#1John G. Elliot (UWA: University of Western Australia)
#2Graham M. Donovan (University of Auckland)H-Index: 11
Last.Peter B. Noble (UWA: University of Western Australia)H-Index: 18
view all 6 authors...
Epidemiological studies report that overweight or obese asthmatic subjects have more severe disease than those of a healthy weight. We postulated accumulation of adipose tissue within the airway wall may occur in overweight patients and contribute to airway pathology. Our aim was to determine the relationship between adipose tissue within the airway wall and body mass index (BMI) in individuals with and without asthma. Transverse airway sections were sampled in a stratified manner from post-mort...
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#1Magnus Ekström (UTS: University of Technology, Sydney)H-Index: 14
#2Sungwon Chang (UTS: University of Technology, Sydney)H-Index: 10
Last.David C. Currow (Hull York Medical School)H-Index: 51
view all 7 authors...
Chronic breathlessness [1] causes immense suffering in cardiorespiratory diseases. The functional impact of activity-related breathlessness, measured on the modified Medical Research (mMRC) scale [2], is highly prognostic, informs disease evaluation and management including in chronic obstructive pulmonary disease (COPD) [3], and is widely used for determining eligibility in clinical trials. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal ...
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Antibiotic discovery and preclinical testing are needed to combat the Pseudomonas aeruginosa health threat. Most frequently, antibiotic efficacy is tested in models of acute respiratory infection, with chronic pneumonia remaining largely unexplored. This approach generates serious concerns about the evaluation of treatment for chronically infected patients, and highlights the need for animal models that mimic the course of human disease. In this study, the efficacy of marketed antibacterials, to...
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#1Howard H.F. TangH-Index: 4
#2Peter D. SlyH-Index: 90
Last.Michael InouyeH-Index: 43
view all 5 authors...
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#1Shintaro Katayama (KI: Karolinska Institutet)H-Index: 12
#2Katarina Stenberg Hammar (KI: Karolinska Institutet)H-Index: 3
Last.Cilla Söderhäll (KI: Karolinska Institutet)H-Index: 28
view all 7 authors...
Background Airway obstruction and wheezing in preschool children with recurrent viral infections are a major clinical problem, and recognised as a risk factor for the development of chronic asthma. We aimed at analyaing whether gene expression profiling provides evidence for pathways that delineate distinct groups of children with wheeze, and in combination with clinical information could contribute to diagnosis and prognosis of disease development. Methods We analyaed leukocyte transcriptomes f...
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