European Respiratory Journal
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#1Robert J. Hancox (University of Otago)H-Index: 43
#2Jane Morgan (Waikato Hospital)H-Index: 9
Last. Joanne Baxter (University of Otago)H-Index: 14
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Functional breathing disorders are common, but poorly understood, causes of respiratory symptoms and often co-exist with asthma and other respiratory diseases [1–3]. Hyperventilation syndrome is the most recognised form of dysfunctional breathing It has long been suspected that dysfunctional breathing may have emotional origins, but there is little empirical evidence to support this [4]. Footnotes This manuscript has recently been accepted for publication in the European Respiratory Journal . It...
#1J. Alberto Neder (Queen's University)H-Index: 22
#2Danilo C. Berton (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 13
Last. Denis E. O’ Donnell (Queen's University)H-Index: 67
view all 6 authors...
Exertional dyspnoea is a cardinal symptom of patients with chronic obstructive pulmonary disease (COPD) [1]. Incremental cardiopulmonary exercise testing (CPET), in particular, might provide useful mechanistic insights into the genesis of this distressing symptom. More recently, there is growing evidence that ventilatory inefficiency (high ventilation (V′E)/carbon dioxide output (V′CO2) nadir) coupled with assessment of operating lung volumes (peak tidal volume (VT)/dynamic inspiratory capacity ...
#1Fredrikus A. Klok (LUMC: Leiden University Medical Center)H-Index: 34
#2Francis CouturaudH-Index: 24
Last. Marc Humbert (French Institute of Health and Medical Research)H-Index: 119
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Chronic thromboembolic pulmonary hypertension (CTEPH) is the most severe long-term complication of acute pulmonary embolism (PE). Untreated, CTEPH is fatal, but, if diagnosed in time, successful surgical (pulmonary endarterectomy), medical (pulmonary hypertension drugs) and/or interventional (balloon pulmonary angioplasty) therapies have been shown to improve clinical outcomes, especially in case of successful pulmonary endarterectomy. Early diagnosis has however been demonstrated to be challeng...
Background Patients with bronchiectasis have a less active lifestyle than healthy peers, but the association with hospital admission has not been explored. The aim of this study was to investigate the association between (i) any physical activity (PA) variable and (ii) sedentary time with hospitalisation due to exacerbation in adults with bronchiectasis. Methods In this prospective observational study, baseline lung function, quality of life, exercise tolerance, severity of bronchiectasis and PA...
#1Pierre-Marie Boutanquoi (French Institute of Health and Medical Research)H-Index: 2
#2Olivier Burgy (French Institute of Health and Medical Research)H-Index: 6
Last. Oleg N. Demidov (French Institute of Health and Medical Research)H-Index: 15
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Rationale Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterised by myofibroblast proliferation and abnormal extracellular matrix (ECM) accumulation in the lungs. Transforming-growth-factor (TGF)-β1 initiates key profibrotic signaling involving the SMADs pathway and the small heat shock protein αB-crystallin (HSPB5). TRIpartite Motif-containing 33 (TRIM33) has been reported to negatively regulate TGF-β/SMADs signaling but its role in fibrogenesis remains unknown. Objectives T...
#1Khadem Ali (University of Newcastle)
#2Richard Y. Kim (University of Newcastle)H-Index: 19
Last. Amber L. Pillar (University of Newcastle)
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Accumulating evidence highlights links between iron regulation and respiratory disease. Here, we assessed the relationship between iron levels and regulatory responses in clinical and experimental asthma. We show that cell-free iron levels are reduced in the bronchoalveolar lavage (BAL) supernatant of severe or mild-moderate asthma patients and correlate with lower forced expiratory volume in 1 s (FEV1). Conversely, iron-loaded cell numbers were increased in BAL in these patients and with lower ...
#1Shona S. Fielding (Aberd.: University of Aberdeen)
#2Mariëlle W. Pijnenburg (Boston Children's Hospital)H-Index: 18
Last. Stanley J. Szefler (University of Colorado Denver)H-Index: 87
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Introduction Fractional exhaled nitric oxide (FENO), a biomarker of eosinophilic airway inflammation, may be useful to guide asthma treatment. FENO guided treatment may be more effective in certain subgroups for improving asthma outcomes compared to standard treatment. Methods An individual patient data analysis was performed using data from seven randomised clinical trials (RCT) which used FENO to guide asthma treatment. The incidence of an asthma exacerbation and loss of control, and the time ...
#1Trung N. Tran (AstraZeneca)H-Index: 8
#2Elizabeth M. KingH-Index: 13
Last. Jennifer K. Quint (Imperial College London)H-Index: 21
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Oral corticosteroids (OCS) are used to manage asthma exacerbations and severe, uncontrolled asthma, but OCS use is associated with adverse effects. We aimed to describe the patterns of OCS use in the real-world management of patients with asthma in western Europe. We used electronic medical records from databases in France, Germany, Italy, and the United Kingdom from July 2011 through February 2018. Patients aged ≥12 years with an asthma diagnosis, ≥1 non-OCS asthma medication within ±6 months o...
#1Kirk Geale (Umeå University)
Last. Alan Altraja (Tartu University Hospital)H-Index: 9
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Asthma is a heterogeneous, chronic airways disease with large variation in prevalence between geographies [1, 2]. In the Nordic countries, prevalence of asthma has been reported to be 10% in Denmark [1], 9–11% in Finland [1, 3], 11–12% in Norway [1], and 8–10% in Sweden [1, 4, 5]. Poor asthma control is associated with substantial reductions in patient quality of life [6–8], higher morbidity and mortality [9, 10], together with significantly increased direct and indirect costs [6, 11]. Footnotes...
#1Gerard McElvaney (RCSI: Royal College of Surgeons in Ireland)
#2Robert A. SandhausH-Index: 24
Last. Elizabeth Sapey (University Hospitals Birmingham NHS Foundation Trust)H-Index: 63
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Alpha-1 Antitrypsin Deficiency (AATD), characterised by reduced levels or functionality of Alpha-1 Antitrypsin (AAT), is a significantly under-diagnosed genetic condition that predisposes individuals to lung and liver disease. Most of the available data on AATD is based on the most common, severe deficiency genotype (PI*ZZ); therefore, treatment and monitoring requirements for individuals with the PI*SZ genotype, which is associated with a less severe AAT deficiency, are not as clear. Recent gen...
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