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European Respiratory Journal
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11.81
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45457
Papers 49505
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We sought to compare the effectiveness of two WHO-recommended regimens for the treatment of rifampin- or multidrug-resistant (RR/MDR) tuberculosis: a standardised regimen of 9–12 months (the “shorter regimen”), and individualised regimens of ≥20 months (“longer regimens”). We collected individual patient data from observational studies identified through systematic reviews and a public call for data. We included patients meeting WHO eligibility criteria for the shorter regimen: not previously tr...
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Introduction Continuous positive airway pressure (CPAP) is currently the treatment of choice for sleepiness in patients with obstructive sleep apnea (OSA), however, adherence is often thought to be suboptimal. We investigated the effects of suboptimal CPAP-usage on objective and subjective sleepiness parameters in patients with OSA. Material and Methods In this 2-week, parallel, double-blind, randomised controlled trial we enrolled moderate-to-severe OSA patients with excessive pre-treatment day...
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Background The nitrogen multiple breath washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. The aim of this study was to generate reference values for N2MBW outcomes in a cohort of healthy Caucasian school-aged children. Methods N2MBW data from healthy Caucasian school-age children between 6 and 18 years were collected from four exper...
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Rationale Studies investigating the risk of active tuberculosis (TB) in association with pregnancy have not been conclusive. We aimed at investigating this risk in a large retrospective register-based cohort study in Sweden. Methods Data from women 15–49 years of age who had given birth in Sweden 2005–2013 were extracted from the National Childbirth Register and linked to the national TB register. Cohort time was divided into three exposure periods: during pregnancy, six months postpartum, and t...
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In 2018, 806 tuberculosis (TB) patients were notified in the Netherlands, which was the second lowest number recorded since notification became mandatory in 1980; only 2017 had less notified cases (n=783) [1]. In this century, TB notification rates in the Netherlands declined by 50%, from 9.3 patients per 100 000 population in 2001 (1492 patients) to 4.7 per 100 000 in 2018. In 2018, 77% of the TB patients were born outside the Netherlands. Footnotes This manuscript has recently been accepted fo...
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The mechanisms underlying pulmonary hypertension (PH) are complex and multifactorial and involve different cell types that are interconnected through gap junctional channels. Although connexin (Cx)-43 is the most abundant gap junction protein in heart and lungs and critically governs intercellular signalling communication, its contribution to PH remains unknown. The focus of the present study is thus to evaluate Cx43 as a potential new target in PH. Expressions of Cx37, Cx40, and Cx43 were studi...
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Residual pulmonary impairment is common after treatment for tuberculosis. Lung function data in patients with HIV-associated tuberculosis are scarce, especially in the context of paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and prophylactic prednisone. We aimed to determine the prevalence of lung function abnormalities in patients with HIV-associated tuberculosis and CD4 counts≤100 cells·μL−1 and assess the effect of prophylactic prednisone and the de...
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The article by Konig and co-workers paves the way for the selection of a subset of patients with CAP in whom combination initial therapy including macrolides could improve outcomes using a new and interesting mathematical approachhttp://bit.ly/2p8RdCD
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A discussion of the strengths and limitations of recent data associating bronchoscopy with mortality in immunocompromised adults with acute hypoxaemic respiratory failurehttp://bit.ly/31mMpGL
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