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Mammalian Genome
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#1Y.F. Liu (SNNU: Shaanxi Normal University)H-Index: 7
#2Yang Jiao (SNNU: Shaanxi Normal University)
Last. Linsen ZanH-Index: 14
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Exploration of genes in relation to body measurement traits through large-scaled mutation identification is highly conductive for the genomics-assisted breeding of superior productivity cattle. In this investigation, 31 objective mutations were genotyped synchronously in 384 yellow cattle of 8 breeds through the application of optimized MALDI-TOF-MS and multiplex PCR techniques. High genotyping rate was obtained as well as greatly decreased cost which was below one thirtieth of the routine analy...
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#1Daniela KasparH-Index: 1
Last. Johannes Beckers (TUM: Technische Universität München)H-Index: 39
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Nutritional constraints including not only caloric restriction or protein deficiency, but also energy-dense diets affect metabolic health and frequently lead to obesity and insulin resistance, as well as glucose intolerance and type 2 diabetes. The effects of these environmental factors are often mediated via epigenetic modifiers that target the expression of metabolic genes. More recently, it was discovered that such parentally acquired metabolic changes can alter the metabolic health of the fi...
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#1Ethan Zhang (NewYork–Presbyterian Hospital)
#2Joseph Ryu (NewYork–Presbyterian Hospital)
Last. Stephen H. Tsang (Columbia University)H-Index: 38
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Retinitis pigmentosa (RP) is a neurodegenerative disorder that causes irreversible vision loss in over 1.5 million individuals world-wide. The genetic heterogeneity of RP necessitates a broad therapy that is able to provide treatment in a gene- and mutation- non-specific manner. In this study, we identify the therapeutic benefits of metabolic reprogramming by targeting pyruvate kinase M2 (PKM2) in a Pde6beta preclinical model of RP. The genetic contributions of PKM2 inhibition in retinal degener...
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#1Hai-Chang Yin (Qiqihar University)
#2Xin-Yu Chen (Harbin Veterinary Research Institute)
Last. Qingwen Meng (Harbin Veterinary Research Institute)H-Index: 1
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RNA polymerase III is an essential enzyme in eukaryotes for synthesis of tRNA, 5S rRNA, and other small nuclear and cytoplasmic RNAs. Thus, RNA polymerase III promoters are often used in small hairpin RNA (shRNA) expression. In this study, the porcine H1, U6, and 7SK RNA polymerase III type promoters were cloned into a pcDNA3.1( +) expression vector containing a shRNA sequence targeting enhanced green fluorescent protein (EGFP). PK and DF-1 cells were cotransfected with the construction of recom...
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#1Justina X Feng (UAB: University of Alabama at Birmingham)
#2Nicole C. Riddle (UAB: University of Alabama at Birmingham)H-Index: 24
Maintaining genome stability is essential to an organism's health and survival. Breakdown of the mechanisms protecting the genome and the resulting genome instability are an important aspect of the aging process and have been linked to diseases such as cancer. Thus, a large network of interconnected pathways is responsible for ensuring genome integrity in the face of the continuous challenges that induce DNA damage. While these pathways are diverse, epigenetic mechanisms play a central role in m...
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#1Alexandra Weyrich (Leibniz Association)H-Index: 5
#2Selma Yasar (University of Potsdam)
Last. Jörns Fickel (University of Potsdam)H-Index: 19
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External temperature change has been shown to modify epigenetic patterns, such as DNA methylation, which regulates gene expression. DNA methylation is heritable, and as such provides a mechanism to convey environmental information to subsequent generations. Studies on epigenetic response to temperature increase are still scarce in wild mammals, even more so studies that compare tissue-specific epigenetic responses. Here, we aim to address differential epigenetic responses on a gene and gene path...
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#1Meriem OuniH-Index: 2
#1Meriem OuniH-Index: 4
Last. Annette Schürmann (University of Potsdam)H-Index: 44
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Obesity is a worldwide epidemic and contributes to global morbidity and mortality mediated via the development of nonalcoholic fatty liver disease (NAFLD), type 2 diabetes (T2D), cardiovascular (CVD) and other diseases. It is a consequence of an elevated caloric intake, a sedentary lifestyle and a genetic as well as an epigenetic predisposition. This review summarizes changes in DNA methylation and microRNAs identified in blood cells and different tissues in obese human and rodent models. It inc...
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Cellular heterogeneity is revolutionizing the way to study, monitor and dissect complex diseases. This has been possible with the technological and computational advances associated to single-cell genomics and epigenomics. Deeper understanding of cell-to-cell variation and its impact on tissue function will open new avenues for early disease detection, accurate diagnosis and personalized treatments, all together leading to the next generation of health care. This review focuses on the recent dis...
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#1Sara Mata López (A&M: Texas A&M University)H-Index: 3
#2Cynthia J. Balog-Alvarez (A&M: Texas A&M University)H-Index: 4
Last. Peter P. Nghiem (A&M: Texas A&M University)H-Index: 8
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The availability of an in vitro canine cell line would reduce the need for dogs for primary in vitro cell culture and reduce overall cost in pre-clinical studies. An immortalized canine muscle cell line, named Myok9, from primary myoblasts of a normal dog has been developed by the authors. Immortalization was performed by SV40 viral transfection of the large T antigen into the primary muscle cells. Proliferation assays, growth curves, quantitative PCR, western blotting, mass spectrometry, and li...
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#1Hyeonjeong Kim (Kyushu University)
#2Minako Yoshihara (Kyushu University)H-Index: 5
Last. Mikita Suyama (Kyushu University)H-Index: 29
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In an alignment of closely related genomic sequences, the existence of discordant mutation sites, which do not reflect the phylogenetic relationship of the genomes, is often observed. Although these discordant mutation sites are thought to have emerged by ancestral polymorphism or gene flow, their frequency and distribution in the genome have not yet been analyzed in detail. Using the genome sequences of all protein coding genes of 25 inbred rat strains, we analyzed the frequency and genome-wide...
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