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#1Patrick M. HonoreH-Index: 20
#2David De BelsH-Index: 10
Last.Kianoush Kashani (Mayo Clinic)H-Index: 24
view all 6 authors...
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#1Heidi Flori (UM: University of Michigan)H-Index: 12
#2Anil Sapru (UCLA: University of California, Los Angeles)H-Index: 21
Last.Mary K. Dahmer (UM: University of Michigan)H-Index: 15
view all 7 authors...
The association of plasma interleukin-8 (IL-8), or IL-8 genetic variants, with pediatric acute respiratory distress syndrome (PARDS) in children with acute respiratory failure at risk for PARDS has not been examined. The purpose of this study was to examine the association of early and sequential measurement of plasma IL-8 and/or its genetic variants with development of PARDS and other clinical outcomes in mechanically ventilated children with acute respiratory failure. This was a prospective co...
1 CitationsSource
#1Edward Palmer (UCL: University College London)H-Index: 1
#2Roman KlapaukhH-Index: 1
Last.Mervyn Singer (UCL: University College London)H-Index: 69
view all 4 authors...
1 CitationsSource
#1Robert Luhr (Örebro University)H-Index: 1
#2Yang Cao (Örebro University)H-Index: 21
Last.Sara Cajander (Örebro University)H-Index: 3
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Background Epidemiologic data have shown an increasing incidence and declining mortality rate in sepsis. However, confounding effects due to differences in disease classification might have contributed to these trends. To assess if a declining mortality over time could be supported by data derived from high-quality prospective studies, we performed a meta-analysis using data from randomised controlled trials (RCTs) on sepsis. The primary aim was to assess whether the mortality in sepsis trials h...
Source
#1Andre C. Kalil (UNMC: University of Nebraska Medical Center)H-Index: 31
#2Paul G. Thomas (St. Jude Children's Research Hospital)H-Index: 42
Influenza virus affects the respiratory tract by direct viral infection or by damage from the immune system response. In humans, the respiratory epithelium is the only site where the hemagglutinin (HA) molecule is effectively cleaved, generating infectious virus particles. Virus transmission occurs through a susceptible individual’s contact with aerosols or respiratory fomites from an infected individual. The inability of the lung to perform its primary function of gas exchange can result from m...
2 CitationsSource
#1Pekka Jakkula (UH: University of Helsinki)H-Index: 3
#2Johanna Hästbacka (UH: University of Helsinki)H-Index: 13
Last.Markus B. Skrifvars (UH: University of Helsinki)H-Index: 24
view all 15 authors...
Cerebral hypoperfusion may aggravate neurological damage after cardiac arrest. Near-infrared spectroscopy (NIRS) provides information on cerebral oxygenation but its relevance during post-resuscitation care is undefined. We investigated whether cerebral oxygen saturation (rSO2) measured with NIRS correlates with the serum concentration of neuron-specific enolase (NSE), a marker of neurological injury, and with clinical outcome in out-of-hospital cardiac arrest (OHCA) patients. We performed a pos...
2 CitationsSource
#1Irene Telias (U of T: University of Toronto)H-Index: 5
#2Mary Elizabeth Wilcox (U of T: University of Toronto)H-Index: 2
Sleep is controlled by two major regulatory systems: a circadian system that drives 24-h periodicity (Process C), and a homeostatic system (Process S) that ensures adequate amounts of sleep are obtained. Both processes are disturbed in critically ill patients, potentially due to exposure to sleep-altering medications (e.g., propofol), the structure of the intensive care unit (ICU) environment (e.g., workflow), aggravation of a pre-existing sleep disorder, and/or effects of acute illness (e.g., s...
3 CitationsSource
#1Ryo Uchimido (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 2
#2Eric P. Schmidt (University of Colorado Denver)H-Index: 19
Last.Nathan I. Shapiro (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 53
view all 3 authors...
The glycocalyx is a gel-like layer covering the luminal surface of vascular endothelial cells. It is comprised of membrane-attached proteoglycans, glycosaminoglycan chains, glycoproteins, and adherent plasma proteins. The glycocalyx maintains homeostasis of the vasculature, including controlling vascular permeability and microvascular tone, preventing microvascular thrombosis, and regulating leukocyte adhesion. During sepsis, the glycocalyx is degraded via inflammatory mechanisms such as metallo...
9 CitationsSource
#2Giuseppe BelloH-Index: 16
Last.M. AntonelliH-Index: 97
view all 12 authors...
Background Data on high-flow nasal oxygen after thoracic surgery are limited and confined to the comparison with low-flow oxygen. Different from low-flow oxygen, Venturi masks provide higher gas flow at a predetermined fraction of inspired oxygen (FiO2). We conducted a randomized trial to determine whether preemptive high-flow nasal oxygen reduces the incidence of postoperative hypoxemia after lung resection, as compared to Venturi mask oxygen therapy.
Source
#1Paul E. Marik (EVMS: Eastern Virginia Medical School)H-Index: 75
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Intensive care medicine
Emergency medicine
Intensive care unit
Sepsis
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