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#1A. P. Kotnova (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 4
#2Yu. V. Ilyin (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 4
Here we attempt to reconstruct the sequence of events that led to the formation of three regulatory piRNA clusters, namely, 20A, 38C and flamenco in the Drosophila melanogaster genome. Both the 38C and flamenco clusters include inverted sequences, which potentially form double-stranded RNA hairpins. We present evidence in favor of the well-known hypothesis of piRNA clusters as "transposon traps". According to this model, the presence of the only copy of the transposon in the genome indicates tha...
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#1I. V. Kukushkina (MSU: Moscow State University)
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The flamenco locus is one of the main components of the piRNA pathway of regulation of mobile genetic elements (MGEs) in Drosophila melanogaster. Mutations at this locus lead to an increase in the transposition activity of MGEs and, as a result, to genetic instability. In this paper, the fertility of a genetically unstable MS strain obtained more than 25 years ago and characterized by a mutation in the flamenco locus and the presence of a functionally active copy of gypsy retrotransposon was inv...
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#1J. J. Li (Gwangju Institute of Science and Technology)
#2Chongsuk Ryou (Hanyang University)H-Index: 16
Last. D.-H. Kim (DGIST: Daegu Gyeongbuk Institute of Science and Technology)
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Recently, SGI-1027, a well-known inhibitor of DNA-methyl transferases (DNMTs), was reported to effectively reduce formation of pathogenic PrP^(Sc) in prion-infected cells. Herein, we confirm the elimination of PrP^(Sc) in chronic wasting disease (CWD) prion-infected neurons by SGI-1027, and pinpoint the binding region of human prion protein to SGI-1027. SGI-1027 is broadly functional against various prion disease types, including human prions. Previously, the inhibitory effects of SGI-1027 on DN...
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#1P. A. Sakharov (RAS: Russian Academy of Sciences)H-Index: 3
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The abundance of noncanonical mechanisms of eukaryotic initiation of translation indicates their involvement in the regulation of protein synthesis during key events in a cell life. One of the well-known examples of a noncanonical cap-independent process is the initiation of translation of mRNA with the 5'-untranslated (leader) region of the messenger encoding for the photoprotein obelin (the obelin leader). In the present work, mRNA with the obelin leader was modified by adding 45 deoxycytidyl ...
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#1H. Sheng (JLU: Jilin University)
#2D. L. Cong (JLU: Jilin University)
Last. H. Y. Ju (JLU: Jilin University)
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Potassium (K^(+)) deficiency in the soil may seriously affect the yield and quality of plants, which usually satisfy their potassium requirements by engaging their K^(+) transporters and/or channels. High-affinity potassium transporter (ZmHAK) family members play crucial role in the uptake and distribution of K^(+) in maize (Zea mays L.). Here, we describe the function of ZmHAK1 promoter and its upstream regulatory transcription factors in maize. In this plant, HAK gene family includes 34 protei...
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#1Sergei Tillib (RAS: Russian Academy of Sciences)H-Index: 21
Methods that utilize highly specific antibodies, anti-idiotypic antibodies, various recombinant molecules with antibody properties and immunocorrection and immunoprophylaxis with the help of vaccines are in demand and are intensely developed in the field of biomedicine. Techniques to generate specific single-domain recombinant antibodies (nanobodies) and their derivatives have raised great expectations in the past years. The review considers the recent literature data on the use of nanobodies in...
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#1Olga V. Kretova (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 10
#2Daria M. Fedoseeva (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 6
Last. Nickolai A. Tchurikov (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 18
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In experiments on mouse and human cells it was demonstrated that rDNA plays an important role in epigenetic regulation of many genes. To identify and study rDNA-contacting genes in Drosophila we used the 4С (circular chromosome conformation capture) approach. We detected very stable contacts of rDNA genes within a 5-kb region inside the Tlk gene residing in X chromosome. This 5-kb region corresponds to small RNAs. After heat shock treatment both the amount of contacts, and the expression level o...
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#1E. A. TrifonovaH-Index: 4
#2A. A. PopovichH-Index: 1
Last. Vadim StepanovH-Index: 16
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Obesity is one of the major challenges in modern society. More than a third of the world's population suffers froms overweight. This phenotype affects the quality of life and is associated with cardiovascular diseases, diabetes, cancer and reproductive disorders. The population variability of allele frequencies of 26 single nucleotide polymorphisms, in association with obesity and body mass index, according to data from genome-wide association studies (GWASs) is discussed in this study. Genetic ...
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#1Irem Uluisik (İzmir Institute of Technology)H-Index: 4
#2Hüseyin Çağlar Karakaya (İzmir Institute of Technology)H-Index: 8
Last. Ahmet Koc (İzmir Institute of Technology)H-Index: 16
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Boric acid is essential for plants and has many vital roles in animals and microorganisms. However, its high doses are toxic to all organisms. We previously screened yeast deletion collections to identify boric acid-resistant and susceptible mutants to identify genes that play a role in boron tolerance. Here, we analyzed boron resistant mutants (elplΔ, elp3Δ, elp6Δ, ncs2Δ, ncs6Δ and ktil2Δ) for their abilities to modulate the general amino acid control system (GAAC) and to induce boron efflux pu...
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#1Lilit Ghukasyan (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 1
#2George S. Krasnov (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 22
Last. Tatyana V. Nasedkina (EIMB: Engelhardt Institute of Molecular Biology)H-Index: 14
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Certain subtypes of acute myeloid leukemia occur as a result of the cooperation of several events these are, the formation of fusion genes as a result of chromosomal rearrangements, which leads to the disruption of cell differentiation, and the emergence of mutations that enhance cellular proliferation by activating intracellular signaling pathways. High-throughput sequencing methods reveal characteristic mutation spectra in leukemia associated with different chromosomal disorders. However, the ...
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