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Health Technology Assessment
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#1Fiona Lobban (Centre for Mental Health)H-Index: 27
#2Nadia Akers (Centre for Mental Health)H-Index: 1
Last. Mahsa Honary (Centre for Mental Health)
view all 22 authors...
BACKGROUND Relatives caring for people with severe mental health problems find information and emotional support hard to access. Online support for self-management offers a potential solution. OBJECTIVE The objective was to determine the clinical effectiveness and cost-effectiveness of an online supported self-management tool for relatives: the Relatives' Education And Coping Toolkit (REACT). DESIGN AND SETTING This was a primarily online (UK), single-blind, randomised controlled trial, comparin...
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#1Mónica Hernández Alava (University of Sheffield)H-Index: 11
#2Allan Wailoo (University of Sheffield)H-Index: 31
Last. Andrea Manca (Ebor: University of York)H-Index: 31
view all 5 authors...
BACKGROUND Cost-effectiveness analysis using quality-adjusted life-years as the measure of health benefit is commonly used to aid decision-makers. Clinical studies often do not include preference-based measures that allow the calculation of quality-adjusted life-years, or the data are insufficient. 'Mapping' can bridge this evidence gap; it entails estimating the relationship between outcomes measured in clinical studies and the required preference-based measures using a different data set. Howe...
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#1Arri Coomarasamy (University of Birmingham)H-Index: 38
#2Hoda Harb (University of Birmingham)H-Index: 7
Last. Abey Eapen (Roy J. and Lucille A. Carver College of Medicine)H-Index: 5
view all 42 authors...
BACKGROUND: Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue a pregnancy in women with early pregnancy bleeding, which is a symptom that is strongly associated with miscarriage. OBJECTIVES: (1) To assess the effects of vaginal micronised progesterone in women with vaginal bleeding in the first 12 weeks of pregnancy. (2) To evaluate the cost-effectiveness of progesterone in women with early pregnancy bleeding. DESIGN: A mu...
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#1Sarah Davis (University of Sheffield)H-Index: 28
#2Emma Simpson (University of Sheffield)H-Index: 19
Last. Peter Selby (University of Manchester)H-Index: 46
view all 9 authors...
BACKGROUND Fragility fractures are fractures that result from mechanical forces that would not ordinarily result in fracture. OBJECTIVES The objectives were to evaluate the clinical effectiveness, safety and cost-effectiveness of non-bisphosphonates {denosumab [Prolia®; Amgen Inc., Thousand Oaks, CA, USA], raloxifene [Evista®; Daiichi Sankyo Company, Ltd, Tokyo, Japan], romosozumab [Evenity®; Union Chimique Belge (UCB) S.A. (Brussels, Belgium) and Amgen Inc.] and teriparatide [Forsteo®; Eli Lill...
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#1Kirsty Winkley ('KCL': King's College London)H-Index: 15
#2Rebecca Upsher ('KCL': King's College London)H-Index: 1
Last. Khalida Ismail ('KCL': King's College London)H-Index: 37
view all 8 authors...
BACKGROUND For people with diabetes mellitus to achieve optimal glycaemic control, motivation to perform self-management is important. The research team wanted to determine whether or not psychological interventions are clinically effective and cost-effective in increasing self-management and improving glycaemic control. OBJECTIVES The first objective was to determine the clinical effectiveness of psychological interventions for people with type 1 diabetes mellitus and people with type 2 diabete...
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#1Rahul Bhatnagar (UoB: University of Bristol)H-Index: 16
#2Ramon Luengo-Fernandez (University of Oxford)H-Index: 24
Last. Nick A Maskell (UoB: University of Bristol)H-Index: 36
view all 6 authors...
BACKGROUND There are around 40,000 new cases of malignant pleural effusion in the UK each year. Insertion of talc slurry via a chest tube is the current standard treatment in the UK. However, some centres prefer local anaesthetic thoracoscopy and talc poudrage. There is no consensus as to which approach is most effective. OBJECTIVE This trial tested the hypothesis that thoracoscopy and talc poudrage increases the proportion of patients with successful pleurodesis at 3 months post procedure, comp...
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#1Juliet Hounsome (University of Liverpool)H-Index: 10
#2G Pilkington (University of Liverpool)H-Index: 5
Last. Rumona Dickson (University of Liverpool)H-Index: 35
view all 8 authors...
BACKGROUND Impacted third molars are third molars that are blocked, by soft tissue or bone, from fully erupting through the gum. This can cause pain and disease. The treatment options for people with impacted third molars are removal or retention with standard care. If there are pathological changes, the current National Institute for Health and Care Excellence guidance states that the impacted third molar should be removed. OBJECTIVE The objective of this study was to appraise the clinical effe...
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#1Hannah Fraser (Warw.: University of Warwick)H-Index: 6
#2Daniel Gallacher (Warw.: University of Warwick)H-Index: 2
Last. Hema Mistry (Warw.: University of Warwick)H-Index: 15
view all 10 authors...
BACKGROUND Sore throat is a common condition caused by an infection of the airway. Most cases are of a viral nature; however, a number of these infections may be caused by the group A Streptococcus bacterium. Most viral and bacterial sore throat infections resolve spontaneously within a few weeks. Point-of-care testing in primary care has been recognised as an emerging technology for aiding targeted antibiotic prescribing for sore throat in cases that do not spontaneously resolve. OBJECTIVE Syst...
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#1Miles D. Witham (Dund.: University of Dundee)H-Index: 33
#2M. Band (Dund.: University of Dundee)H-Index: 11
Last. Gwen Kennedy (Dund.: University of Dundee)H-Index: 19
view all 17 authors...
BACKGROUND Advanced chronic kidney disease is common in older people and is frequently accompanied by metabolic acidosis. Oral sodium bicarbonate is used to treat this acidosis, but evidence is lacking on whether or not this provides a net gain in health or quality of life for older people. OBJECTIVES The objectives were to determine whether or not oral bicarbonate therapy improves physical function, quality of life, markers of renal function, bone turnover and vascular health compared with plac...
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#1David J Beard (University of Oxford)H-Index: 49
#2Loretta Davies (University of Oxford)H-Index: 4
Last. Helen Campbell (University of Oxford)H-Index: 18
view all 14 authors...
BACKGROUND: Late-stage medial compartment knee osteoarthritis can be treated using total knee replacement or partial (unicompartmental) knee replacement. There is high variation in treatment choice and insufficient evidence to guide selection. OBJECTIVE: To assess the clinical effectiveness and cost-effectiveness of partial knee replacement compared with total knee replacement in patients with medial compartment knee osteoarthritis. The findings are intended to guide surgical decision-making for...
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Top fields of study
Randomized controlled trial
Intensive care medicine
Physical therapy
Psychological intervention
Cost effectiveness
Medicine