Molecular and Cellular Endocrinology
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#1Minyi Zhang (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Jinsong LiuH-Index: 25
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Abstract Hepatic nuclear factor 4 alpha (HNF4α) drives the expression of apolipoprotein B (ApoB), microsomal triglyceride transfer protein (MTP) and phospholipase A2 G12B (PLA2G12B), governing hepatic very-low-density lipoprotein (VLDL) production and secretion. Andrographolide (AP) is a major constituent isolated from Andrographis paniculata. We found that AP can disrupt the interaction between HNF4α and its coactivator peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α...
#2Stephen J. Winters (University of Louisville)H-Index: 35
Last. Joseph P. Moore (University of Louisville)H-Index: 10
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Abstract Pituitary adenylate cyclase-activating polypeptide (PACAP) is thought to play a role in the development and regulation of gonadotrophs. PACAP levels are very high in the rodent fetal pituitary, and decline substantially and rapidly at birth, followed by a significant rise in FSHβ and GnRH-R expression. Because there is evidence that PACAP stimulates its own transcription, we propose that this self-regulation is interrupted around the time of birth. To begin to examine the mechanisms for...
#1Sean M. HolloranH-Index: 1
Last. Christy R. Hagan (KU: University of Kansas)H-Index: 2
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Abstract Progesterone and prolactin are two key hormones involved in development and remodeling of the mammary gland. As such, both hormones have been linked to breast cancer. Despite the overlap between biological processes ascribed to these two hormones, little is known about how co-expression of both hormones affects their individual actions. Progesterone and prolactin exert many of their effects on the mammary gland through activation of gene expression, either directly (progesterone, bindin...
#1Simona Nanni (UCSC: Catholic University of the Sacred Heart)H-Index: 21
#2Lorenza Bacci (UCSC: Catholic University of the Sacred Heart)H-Index: 3
Last. Antonella Farsetti (National Research Council)H-Index: 31
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Abstract Prostate cancer (PCa) is a sex-steroid hormone-dependent cancer in which estrogens play a critical role in both initiation and progression. Recently, several long non-coding RNAs (lncRNAs) have been associated with PCa and are supposedly playing a pivotal role in the biology and progression of this type of cancer. In this review, we focused on some lncRNAs that are known for their androgen and estrogen transcriptional responsiveness in PCa. Specifically, we summarized recent pieces of e...
Abstract G protein-coupled receptors (GPCRs) are highly conserved versatile signaling molecules located at the plasma membrane that respond to diverse extracellular signals. They regulate almost all physiological processes in the vertebrates. About 35% of current drugs target these receptors. Mutations in these genes have been identified as causes of numerous diseases. The seven transmembrane domain structure of GPCRs implies that the folding of these transmembrane proteins is extremely complica...
#1Andreas Lindqvist (Lund University)H-Index: 16
#2Liliya Shcherbina (Lund University)H-Index: 7
Last. Leif Groop (Lund University)H-Index: 133
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Abstract It is not known how ghrelin affects insulin secretion in human islets from patients with type 2 diabetes (T2D) or whether islet ghrelin expression or circulating ghrelin levels are altered in T2D. Here we sought out to identify the effect of ghrelin on insulin secretion in human islets and the impact of T2D on circulating ghrelin levels and on islet ghrelin cells. The effect of ghrelin on insulin secretion was assessed in human T2D and non-T2D islets. Ghrelin expression was assessed wit...
#1Luciana Abreu da Rosa (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 2
#2Gustavo Monteiro Escott (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 3
Last. Eloisa da Silveira Loss (UFRGS: Universidade Federal do Rio Grande do Sul)H-Index: 10
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Abstract Testosterone (T) and its 17-α epimer, epitestosterone (EpiT), are described as having non-classical effects in addition to their classical androgen actions via the intracellular androgen receptor (iAR). The actions of these androgens play an essential role in triggering factors that shift Sertoli cells from the proliferation phase to the maturation phase. This process is essential for successful spermatogenesis and normal fertility. The aim of this work was to investigate the difference...
#1Jiahui Hu (YZU: Yangzhou University)H-Index: 1
#2Jiaqi Jin (YZU: Yangzhou University)H-Index: 1
Last. Fenglei Chen (YZU: Yangzhou University)H-Index: 1
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Abstract ER oxidoreduclin 1α (ERO1α), an oxidase that exists in the ER, participates in protein folding and secretion and inhibiting apoptosis, and regulates tumor progression, which is a novel factor of poor cancer prognosis. However, the other physiological functions of ERO1α remain undiscovered. Although our preliminary results of this study indicated that ERO1α revealed the robust expression in ovary, especially in granulosa cells, the role of ERO1α in follicular development is not well know...
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Molecular biology