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Clinical Therapeutics
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#1Alexander M. Newman (NU: Northwestern University)
#2Ravi Jhaveri (NU: Northwestern University)
Abstract Varicella zoster and herpes zoster are infections caused by the highly contagious varicella-zoster virus (VZV). Despite widespread availability of vaccines against VZV, as well as varicella vaccination rates >95%, VZV remains a public health concern because of several common myths and misconceptions. Because of the success of routine varicella vaccination programs, some people mistakenly believe that varicella and herpes zoster are now no longer a threat to public health. Another common...
#1Marissa Bolson Serafin (UFSM: Universidade Federal de Santa Maria)
#2Angelita Bottega (UFSM: Universidade Federal de Santa Maria)H-Index: 2
Last.Rosmari Hörner (UFSM: Universidade Federal de Santa Maria)H-Index: 8
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#1Yanguo Xin (Sichuan University)H-Index: 1
#2Junli Li (Sichuan University)H-Index: 3
Last.Xiaojing Liu (Sichuan University)H-Index: 5
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Abstract Purpose Many patients with acute coronary syndrome may experience recurrent myocardial infarction although they are receiving optional therapy, but they are still associated with poor clincial outcomes. The goal of this study was to assess different antiplatelet strategies in these patients. Methods This retrospective trial compared ticagrelor (180-mg loading dose, 90-mg BID maintenance dose) and clopidogrel (300- to 600-mg loading dose, 150-mg daily maintenance dose) for the prevention...
#1Elisha M. Wachman (BMC: Boston Medical Center)H-Index: 7
#2Kelley Saia (BMC: Boston Medical Center)H-Index: 7
Last.Hendrée E. Jones (UNC: University of North Carolina at Chapel Hill)H-Index: 29
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ABSTRACT Purpose The use of the opioid antagonist naltrexone (NTX) for pregnant women with opioid use disorder (OUD) remains understudied. The purpose of this pilot study was to examine pregnancy and neonatal outcomes in a cohort of NTX-treated women. Methods This single-center, retrospective cohort study included 6 mother–infant dyads taking NTX compared with 13 taking buprenorphine (BUP) between 2017 and 2019. Maternal demographic characteristics, any unprescribed or illicit opioid use per uri...
#1Richard Haynes (University of Oxford)H-Index: 15
#2Elsa Valdes-Marquez (Clinical Trial Service Unit)H-Index: 4
Last.Yale B. MitchelH-Index: 34
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Abstract Purpose The Heart Protection Study 2–Treatment of HDL to Reduce the Incidence of Vascular Events (HPS2-THRIVE) trial of patients at high risk of vascular disease found that adding extended-release niacin-laropiprant to intensive statin-based LDL-lowering therapy had no benefit on cardiovascular outcomes. However, the trial also identified previously unrecognized serious adverse effects (including new-onset diabetes, bleeding, and infection). Our objective was to explore the safety profi...
Abstract Purpose People with diabetes taking insulin are at risk of severe hypoglycemia, an unpredictable, life-threatening event that requires assistance from others. Outside the clinical setting, glucagon is indicated for the treatment of hypoglycemia. However, there is significant unmet medical need to improve successful administration of glucagon by caregivers and acquaintances. This study assesses perceptions about glucagon delivery and potential effects of 2 glucagon delivery devices for s...
#1Takayuki KatsubeH-Index: 8
#2Toshihiro WajimaH-Index: 11
Last.Takeshi KanoH-Index: 3
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Abstract Purpose Lusutrombopag is a novel, orally active thrombopoietin receptor agonist. This report describes 3 studies aimed at assessing the effects of food and calcium carbonate on the pharmacokinetic parameters of lusutrombopag in healthy subjects. Methods Three single-dose, open-label crossover studies were conducted. In study 1, eighteen healthy subjects were administered a single 2-mg dose of lusutrombopag as a single tablet in the fasted or fed state or as a 2-mg solution in the fasted...
#1Seol Ju Moon (CBNU: Chonbuk National University)H-Index: 2
#2Ji-Young Jeon (CBNU: Chonbuk National University)H-Index: 6
Last.Min-Gul Kim (CBNU: Chonbuk National University)H-Index: 10
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Abstract Purpose Hypertension is a major risk factor for cardiovascular diseases, necessitating hypertension control. Antihypertensive drugs are more potent when administered in combinations of 2 or 3 different classes of drugs. One such therapy includes a combination of an angiotensin receptor blocker, a calcium channel blocker, and a diuretic. The objective of this study was to evaluate the pharmacokinetic interaction among telmisartan, amlodipine, and hydrochlorothiazide. Methods : A randomiz...
Abstract Purpose In China, although insulin has been prescribed for decades, glucagon-like peptide 1 receptor agonists (GLP-1-RAs) have been available as an injectable treatment for patients with type 2 diabetes mellitus (T2DM) since 2009. GLP-1 RAs are listed as second-line treatment in the 2017 Chinese Guideline for patients with T2DM in whom prior oral antidiabetic therapy has failed. This study compares the baseline characteristics of Chinese patients with T2DM taking different prescriptions...
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