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Clinical Therapeutics
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#1Maura S. Oliveira (USP: University of São Paulo)H-Index: 10
#2Anna Silva Machado (USP: University of São Paulo)H-Index: 4
Last. Anna S. Levin (USP: University of São Paulo)H-Index: 31
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Abstract Purpose Antibiotic dosing is challenge in critically ill patients undergoing renal replacement therapy. Our aim was to evaluate the pharmacokinetic and pharmacodynamic (PK/PD) characteristics of meropenem and vancomycin in patients undergoing SLED. Methods Consecutive ICU patients undergoing SLED and receiving meropenem and/or vancomycin were prospectively evaluated. Serial blood samples were collected before, during, and at the end of SLED sessions. Antimicrobial concentrations were de...
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#1Gabriel TremblayH-Index: 3
#2M. DolphH-Index: 2
Last. Anna ForsytheH-Index: 5
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Abstract Purpose Eltrombopag was evaluated as a second-line treatment for adult chronic immune thrombocytopenia (ITP) in the 2006 Phase III RAISE (Eltrombopag for Management of Chronic Immune Thrombocytopenia) randomized, placebo-controlled trial. More than 80% of patients reached satisfactory platelet counts within 2 weeks. However, the economic value of eltrombopag as a second-line treatment for ITP remains to be formally assessed. This study aimed to estimate the cost-effectiveness of treatin...
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#1Sultan Aydin Koker (Boston Children's Hospital)H-Index: 2
#2Yeşim Oymak (Boston Children's Hospital)H-Index: 5
Last. Raziye C. Vergin (Boston Children's Hospital)H-Index: 1
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Abstract l -Asparaginase ( l -Asp) is a critical component of chemotherapy for acute lymphoblastic leukemia (ALL). However, toxic effects associated with l -Asp, such as hepatic dysfunction, pancreatitis, hypercholesterolemia, and hyperglycemia, have occurred. In addition, acute pancreatitis is a significant life-threatening adverse event associated with ALL. We describe 2 patients with ALL who had l -Asp–associated pancreatitis (AAP), with one patient presenting with hyperglycemia and the other...
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#1Duraisamy Kempuraj (MU: University of Missouri)H-Index: 35
#2Mohammad Ejaz Ahmed (MU: University of Missouri)H-Index: 7
Last. Asgar Zaheer (MU: University of Missouri)H-Index: 29
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Abstract Purpose Psychological stress is a significant health problem in veterans and their family members. Traumatic brain injury (TBI) and stress lead to the onset, progression, and worsening of several inflammatory and neurodegenerative diseases in veterans and civilians. Alzheimer's disease (AD) is a progressive, irreversible neuroinflammatory disease that causes problems with memory, thinking, and behavior. TBIs and chronic psychological stress cause and accelerate the pathology of neuroinf...
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#1Xia Chen (Capital Medical University)H-Index: 1
#2Nuoer Sang (Peking Union Medical College Hospital)
Last. Pei Hu (Peking Union Medical College Hospital)H-Index: 14
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Abstract Purpose Remimazolam tosylate (HR-7056) is a novel ester-type benzodiazepine with ultrafast onset of effect. The compound is being developed for sedation induction and maintenance during anesthesia. It was approved for procedural anesthesia in December 2019 by the National Medical Products Administration of China. Previous studies have reported on remimazolam's effects on consciousness and cognition. Although the time to full psychomotor recovery after remimazolam-mediated sedation is cr...
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#1Hitoshi Kawazoe (Ehime University)H-Index: 4
#2Natsuki Mori (Ehime University)
Last. Satomi Sumikawa (Ehime University)H-Index: 3
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Abstract Purpose Venous pain induced by peripheral intravenous infusion of gemcitabine has remained an unresolved issue in clinical practice. This study aimed to identify differences between gemcitabine formulations as well as risk factors associated with gemcitabine-induced venous pain in patients with cancer. Methods We retrospectively analyzed data from consecutive patients with cancer who had received chemotherapy including a lyophilized or liquid formulation of gemcitabine diluted with 5% g...
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#1Megan L. Evans (Tufts Medical Center)H-Index: 3
#2Alyson J. McGregor (Brown University)H-Index: 10
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#1Noriaki Hidaka (Ehime University)H-Index: 5
#2Yuichi Kaji (Matsuyama University)
Last. Mamoru Tanaka (Ehime University)H-Index: 6
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Abstract Purpose Acetaminophen has been increasingly used for the treatment of cancer-related pain in Japan since the revision of the package insert on January 21, 2011. However, high-dose acetaminophen may cause liver injury. The objectives of this study were to investigate the prevalence of liver injury in patients receiving acetaminophen and to identify the risk factors. Methods The subjects were patients who were treated with acetaminophen ≥1500 mg/d for ≥4 weeks at Ehime University Hospital...
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#2Anthony M. CasapaoH-Index: 11
Last. Veena VenugopalanH-Index: 4
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PURPOSE: The search for new agents to treat multidrug-resistant gram-negative bacterial infections has been ongoing. Specifically, carbapenem-resistant Enterobacteriaceae (CRE) infections often exhibit multiple resistance mechanisms, including alterations in drug structure, bacterial efflux pumps, and drug permeability. Vaborbactam, a cyclic boronic acid pharmacophore, has the highest potency in vitro with meropenem as an inhibitor of class A carbapenemases, including Klebsiella pneumoniae carba...
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