American Journal of Cardiology
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ABSTRACT To better understand the evolvement of the pulmonary dysfunction in the aging ventricular septal defect (VSD) patient, we invited adult patients with a congenital VSD and healthy age- and gender-matched controls for static and dynamic spirometry, impulse oscillometry, multiple breath washout, and diffusion capacity for carbon monoxide testing. Primary outcome was forced expiratory volume in 1 second. In total, 30 patients with a surgically corrected VSD (mean age 51±8 years), 30 patient...
#1Giovanni La CannaH-Index: 34
#2Iside ScarfòH-Index: 2
Last. Ottavio AlfieriH-Index: 72
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ABSTRACT Dynamic left ventricular (LV) obstruction has important clinical and therapeutic implications in patients with hypertrophic cardiomyopathy (HC). Although absent at rest, LV obstruction may be elicited using varying stressors. Meal-related hemodynamic changes may favor LV obstruction and support post-prandial (PP) symptoms in HC patients. The aim of this study was to evaluate PP- LV obstruction inducibility in HC patients in comparison with fasting Valsalva maneuver and exercise test. Ni...
Abstract Clinical spectrum of hypertrophic cardiomyopathy (HC) has been expanded to include patients with mild or no thickening of the left ventricle (LV), who nevertheless have outflow tract obstruction at rest or after exercise, due to systolic anterior motion (SAM) and ventricular septal contact, with mitral valve elongation and papillary muscles anomalies. Apical ballooning mimicking a takotsubo syndrome (TS) wall motion pattern can occur in HC with mild septal thickening when latent obstruc...
#1Tatiana BusuH-Index: 3
#2Safi U. Khan (WVU: West Virginia University)H-Index: 2
Last. Mohamad AlkhouliH-Index: 10
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Abstract Data on the efficacy of left atrial appendage occlusion (LAAO) in clinical practice are limited. We performed a systematic review and meta-analysis of observational studies that reported observed vs. expected rates of ischemic strokes and/or major bleeding following LAAO. Our primary end points were the pooled relative risk reduction (RRR) in ischemic stroke and major bleeding with corresponding 95% confidence intervals (CI) compared with what was expected by the CHA2DS2-VASc and HASBLE...
#1Anna SzymanskaH-Index: 2
#2Anna E. Płatek (Medical University of Warsaw)H-Index: 8
Last. Filip M. Szymański (Medical University of Warsaw)H-Index: 12
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Abstract In many cases, atrial fibrillation (AF) is associated with a history of cardiac inflammation. One of the potential pathogens responsible for atrial inflammation might by Borrelia burgdorferi – a pathogen involved in Lyme carditis. This study aimed to assess whether the serological history of Borrelia infection was associated with the risk of AF. The study included 113 AF patients and 109 patients in sinus rhythm. All patients underwent a clinical evaluation, echocardiography and had the...
#1Fangyuan Zhang (Keele University)
#2Mohamed Mohamed (Keele University)H-Index: 3
Last. Mamas A. Mamas (Keele University)H-Index: 39
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Abstract Despite current evidence, little is known about the impact of comorbidity burden on invasive management strategies and clinical outcomes in the context of acute coronary syndrome (ACS). All ACS hospitalizations between 2004 and 2014 from the National Inpatient Sample were included, stratified by Elixhauser Comorbidity Score (ECS) and number of Elixhauser Comorbidities (NEC) to compare the receipt of invasive management and clinical outcomes between different ECS and NEC classes to the l...
#1Ayman ElbadawiH-Index: 7
#1Ayman Elbadawi (UTMB: University of Texas Medical Branch)H-Index: 3
Last. Hani JneidH-Index: 28
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#1Talal S. Alnabelsi (UK: University of Kentucky)
#1Talal AlnabelsiH-Index: 4
Last. Vincent L. SorrellH-Index: 12
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Cardiovascular complications are reported in up to 30% of sepsis survivors. Currently, there is limited evidence to guide cardiovascular risk stratification of septic patients. We propose the use of left ventricular ejection fraction (LVEF) and coronary artery calcification (CAC) on nongated computed tomography (CT) scans to identify septic patients at highest risk for major adverse cardiovascular events (MACE). We retrospectively reviewed 517 adult patients with sepsis, elevated troponin levels...
Top fields of study
Coronary artery disease
Heart disease
Myocardial infarction
Diabetes mellitus