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Biology of Sex Differences
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3.19
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334
Papers 348
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Estrogen plays substantial roles in pain modulation; however, studies concerning sex hormones and nociception often yield confusing results. The discrepancy could be a result of lack of consensus to regard estrogen as a variable when working with animal models; thus, the influence of hormones’ fluctuations on nociception has continually been neglected. In the present study, we designed a novel hormone substitution model to aid us to evaluate the effects of estrogen’s long-term alterations on ova...
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Diabetes is a strong risk factor for vascular disease. There is compelling evidence that the relative risk of vascular disease associated with diabetes is substantially higher in women than men. The mechanisms that explain the sex difference have not been identified. However, this excess risk could be due to certain underlying biological differences between women and men. In addition to other cardiometabolic pathways, sex differences in body anthropometry and patterns of storage of adipose tissu...
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#1Takahiko Yoshimoto (Showa University)H-Index: 1
#2Hirotaka Ochiai (Showa University)H-Index: 12
Last.Akatsuki Kokaze (Showa University)H-Index: 12
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Background Although some recent studies have indicated an association between metabolic syndrome (MetS) and musculoskeletal disease, little is known about the association of MetS with low back pain (LBP). The present study aimed to investigate sex differences in the association of MetS and the clustering of MetS components with LBP among middle-aged Japanese individuals.
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#1Rachel-Karson Thériault (U of G: University of Guelph)H-Index: 1
#2Melissa L. Perreault (U of G: University of Guelph)H-Index: 15
Major depressive disorder (MDD) is a debilitating chronic illness that is two times more prevalent in women than in men. The mechanisms associated with the increased female susceptibility to depression remain poorly characterized. Aberrant neuronal oscillatory activity within the putative depression network is an emerging mechanism underlying MDD. However, innate sex differences in network activity and its contribution to depression vulnerability have not been well described. In this review, cur...
1 CitationsSource
#1Anjali Ghimire (Dal: Dalhousie University)H-Index: 2
#2Elise S Bisset (Dal: Dalhousie University)H-Index: 1
Last.Susan E. Howlett (Dal: Dalhousie University)H-Index: 32
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Background Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R). While endogenous estrogen is beneficial in I/R, whether testosterone is involved is uncertain and whether age modifies responses to I/R is unclear. We investigated sex- and age-specific differences in I/R injury in the hearts pre-treated with clinically relevant cardioplegic solutio...
1 CitationsSource
Over a third of reproductive-age women in the USA are obese, and the prevalence of cardiovascular disease (CVD) is rising in premenopausal women. Cardiac hypertrophy is an independent predictor of CVD. In contrast to pregnancy, where transiently increased left ventricular (LV) mass is not associated with cardiac damage, obesity-mediated cardiac hypertrophy is pathological. There is a paucity of data describing the effect of obesity during pregnancy on maternal cardiovascular health. The purpose ...
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#1Sander Galjaard (Katholieke Universiteit Leuven)H-Index: 10
#2Lieveke Ameye (Katholieke Universiteit Leuven)H-Index: 19
Last.Roland Devlieger (Katholieke Universiteit Leuven)H-Index: 41
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Background According to the WHO Multicentre Growth Reference Study Group recommendations, boys and girls have different growth trajectories after birth. Our aim was to develop gender-specific fetal growth curves in a low-risk population and to compare immediate birth outcomes.
1 CitationsSource
#1Shuchun Lin (CAS: Chinese Academy of Sciences)H-Index: 1
#2Yun Liu (Fudan University)H-Index: 17
Last.Ying Gao (CAS: Chinese Academy of Sciences)H-Index: 96
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Men are at higher risk of developing chronic lymphocytic leukemia (CLL) than women. DNA methylation has been shown to play important roles in a number of cancers. There are differences in the DNA methylation pattern between men and women. In this study, we investigated whether this contributes to the sex-related difference of B cell CLL risk. Using the HumanMethylation450 BeadChip, we profiled the genome-wide DNA methylation pattern of CD19+ B cells from 48 CLL patients (29 female patients and 1...
2 CitationsSource
#1Melissa C. White (PSU: Pennsylvania State University)
#2Amanda J. Miller (PSU: Pennsylvania State University)H-Index: 4
Last.Amy C. Arnold (PSU: Pennsylvania State University)H-Index: 15
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Background Angiotensin-(1-7) is a beneficial hormone of the renin-angiotensin system known to play a positive role in regulation of blood pressure and glucose homeostasis. Previous studies have shown that in high-fat diet (HFD)-induced obese male mice, circulating angiotensin-(1-7) levels are reduced and chronic restoration of this hormone reverses diet-induced insulin resistance; however, this has yet to be examined in female mice. We hypothesized angiotensin-(1-7) would improve insulin sensiti...
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#1Sierra J. Stringfield (UNC: University of North Carolina at Chapel Hill)H-Index: 6
#2Aric C. Madayag (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last.Donita L. Robinson (UNC: University of North Carolina at Chapel Hill)H-Index: 22
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Background Nicotine exposure enhances Pavlovian conditioned approach (PCA), or the learned approach to reward-predictive cues. While females show elevated approach to conditioned stimuli compared to males, potentially indicating heightened addiction vulnerability, it is unknown how sex may interact with nicotine to influence approach behavior. Additionally, brain-derived neurotrophic factor (BDNF) levels can be altered significantly after repeated nicotine exposure, suggesting a potential mechan...
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Top fields of study
Sexual dimorphism
Endocrinology
Disease
Diabetes mellitus
Medicine
Biology