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The International Journal of Biochemistry & Cell Biology
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3.14
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5297
Papers 5365
1 page of 537 pages (5,365 results)
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#1Abdelaziz Ghanemi (Laval University)H-Index: 2
#2Aicha Melouane (Laval University)H-Index: 1
Last.Jonny St-Amand (Laval University)H-Index: 14
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Abstract The extracellular matrix (ECM) remodeling plays important roles in both adipocytes shape/expansion remodeling and the skeletal muscle (SM) metabolism. Secreted protein acidic and rich in cysteine (SPARC) is expressed in divers tissues including adipose tissue (AT) and SM where it impacts a variety of remodeling as well as metabolic functions. SPARC, also known as osteonectin or BM-40, is a glycoprotein associated with the ECM. Numerous researches attempted to elucidate the implications ...
#1Huang Guo-Wei (STU: Shantou University)
#2Li Chun-Quan (HMU: Harbin Medical University)
Last.Xu Liyan (STU: Shantou University)
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Abstract Although Signal transducer and activator of transcription 1 (STAT1)-mediated transactivation potential is inhibited in cancer cells, the mechanism is poorly understood. In the present study, we implicated long non-coding RNA lncRNA625 in the inhibition of STAT1 activity. LncRNA625 knockdown up-regulated STAT1-mediated transcription and resulted in an increase of STAT1-mediated expression of IFITM2. Conversely, lncRNA625 upregulation inhibited STAT1 reporter activity. Mechanistically, ln...
#1Fabrizio Damiano (University of Salento)H-Index: 15
#2Laura Giannotti (University of Salento)H-Index: 2
Last.Antonio Gnoni (University of Bari)H-Index: 19
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Abstract Quercetin (Que), a widely distributed flavonoid in the human diet, exerts neuroprotective action because of its property to antagonize oxidative stress. Here, we investigated the effects of Que on lipid synthesis in C6 glioma cells. A rapid Que-induced inhibition of cholesterol and, to a lesser extent, of fatty acid synthesis from [1-14C]acetate was observed. The maximum decrease was detected at the level of palmitate, the end product of de novo fatty acid synthesis. The effect of Que o...
#1Mayssa Abdelwahed (University of Sfax)
#2Y. ChaabouniH-Index: 3
Last.Neila Belguith (University of Sfax)H-Index: 7
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Abstract Autosomal dominant tubulointerstitial kidney disease (ADTKD) is a rare group of disease that affect the tubules of the kidney. There are 4 known subtypes of ADTKD classified based on causative genes and clinical features. In our study, we aimed to identify the causative subtypes of ADTKD in a Tunisian ADTKD family (3 affected members), in whom standard nephrological diagnosis did not provide clear subtype of ADTKD, until genetic testing was performed. Sanger sequencing was performed for...
Abstract Circular RNAs (circRNAs) are novel endogenous non-coding RNAs that are generated by reverse-splicing of precursor mRNA derived from various genes in mammals. Despite low expression, recent studies have shown that circRNA plays an important role in skeletal muscle myogenesis with competing endogenous RNA (ceRNA) functions. However, the potential regulatory role of circRNAs and interactions with miRNAs remain largely unexplored, and the function of circRNAs as miRNA sponges is not yet gen...
#1Minxue Zhang (WMU: Wenzhou Medical College)H-Index: 1
#2Haixu Weng (WMU: Wenzhou Medical College)H-Index: 1
Last.Juke Zheng (WMU: Wenzhou Medical College)H-Index: 1
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Abstract Endothelial-to-mesenchymal transition (EndMT) plays an important role in the progression of cardiac fibrosis but its mechanism and treatment need to be further understood. Herein, we have found that mitochondrial unfolded protein response (mtUPR) played a critical role in transforming growth factor beta 1 (TGF-β1)-induced EndMT in endothelial cells (ECs). MtUPR was repressed in endothelial cells after exposure to TGF-β1. NAD + precursor nicotinamide riboside (NR) could attenuate TGF-β1-...
#1Sy Giin Chong (St. Joseph's Healthcare Hamilton)
#2Seidai Sato (St. Joseph's Healthcare Hamilton)
Last.Jack Gauldie (St. Joseph's Healthcare Hamilton)
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Abstract Fibroblasts are considered major contributors to the process of fibrogenesis and the progression of matrix deposition and tissue distortion in fibrotic diseases such as Pulmonary Fibrosis. Recent discovery of the fibrocyte, a circulating possible precursor cell to the tissue fibroblast in fibrosis, has raised issues regarding the characterization of fibrocytes with respect to their morphology, growth characteristics in vitro, their biological role in vivo and their potential utility as ...
#1Zi Liang (Soochow University (Suzhou))H-Index: 5
#2Yahong Lu (Soochow University (Suzhou))H-Index: 2
Last.Guangli Cao (Soochow University (Suzhou))H-Index: 11
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Abstract Yorki (Yki), a transcriptional co-activator that is a key component of the Hippo pathway, induces the transcription of a number of targets that promote cell proliferation and survival. Bombyx mori Yki3 (BmYki3), with 445 amino acid residues, facilitates cell migration and cell division, and enlarges cultured cell and wing disc size. In this study, cellular localization, transcriptional co-activator activity, cell migration, cell cycle, and cell size were characterized in alternative iso...
#1Faranak Alipour (Shahid Beheshti University of Medical Sciences and Health Services)
#2Niknam Riyahi (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 1
Last.Davood Bashash (Shahid Beheshti University of Medical Sciences and Health Services)H-Index: 9
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Abstract Although conventional therapeutic approaches have brought remarkable advantages for the treatment of breast cancer (BC), drug-resistance still remains as a leading cause of tumor recurrence in this malignancy. In the present study, we designed experiments to evaluate the therapeutic value of PI3K inhibition in combination with Arsenic trioxide (ATO) in MCF-7 cells. The results of our study manifested that BKM120 sensitized MCF-7 cells to the lower concentrations of ATO. The significant ...
#1Aida ZuluetaH-Index: 6
#2Valeria PeliH-Index: 1
Last.Elena Del Favero (University of Milan)H-Index: 17
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Abstract Ceramide is emerging as one of the players of inflammation in lung diseases. However, data on its inflammatory role in Cystic Fibrosis (CF) as part of the extracellular machinery driven by lung mesenchymal stem cells (MSCs)-derived extracellular vesicles (EVs) are missing. We obtained an in vitro model of CF-MSC by treating control human lung MSCs with a specific CFTR inhibitor. We characterized EVs populations derived from MSCs (ctr EVs) and CF-MSCs (CF-EVs) and analyzed their sphingol...
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