The International Journal of Biochemistry & Cell Biology
IF
3.25
Papers
5249
Papers 5236
1 page of 524 pages (5,236 results)
Newest
Ahmed A. Raslan2
Estimated H-index: 2
(Soonchunhyang University),
Jeong Kyo Yoon (Soonchunhyang University)
Abstract R-spondins (RSPOs) are secreted cysteine-rich glycoproteins that belong to a superfamily of t hrombo s pondin type 1 r epeat-containing proteins. RSPOs together with WNT proteins potentiate canonical WNT/β-catenin signaling activity. Over the last several years, the understanding of the regulatory mechanisms and functional roles of RSPOs in many biological contexts has increased. Particularly, because a leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), a stem cell mark...
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Kai Yan (Second Military Medical University), Yong Fu6
Estimated H-index: 6
(Second Military Medical University)
+ 6 AuthorsJing-hai Song
Abstract Background Immunotherapy is a promising method for the treatment of hepatocellular carcinoma (HCC), in which CD8 + T cells play a key role. The influence of long noncoding RNA (lncRNA) nuclear-enriched autosomal transcript 1(NEAT1) on the antitumor activity of CD8 + T cells was clarified in this study. Methods Peripheral blood mononuclear cells (PBMCs) were isolated from HCC patients, and the expressions of NEAT1 and Tim-3 were determined by qRT-PCR and western blot, respectively. CD8 +...
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Dorota Dymkowska11
Estimated H-index: 11
(Nencki Institute of Experimental Biology),
Beata Drabarek4
Estimated H-index: 4
(Nencki Institute of Experimental Biology)
+ 2 AuthorsKrzysztof Zabłocki14
Estimated H-index: 14
(Nencki Institute of Experimental Biology)
Abstract Previously we showed that a mild stimulation of EA.hy926 cells with tumour necrosis factor alpha (TNFα) activated mitochondrial biogenesis, probably as a mechanism preventing cell death. This was accompanied by an increased phosphorylation of eNOS and elevation of NO release. The aim of the present study was to explain the biochemical basis of this effect. Our results indicate that eNOS is the only enzyme catalysing NO generation in EA.hy926 cells, and TNFα stimulates its activity by ac...
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Petr Ježek27
Estimated H-index: 27
,
Tomáš Špaček8
Estimated H-index: 8
+ 1 AuthorsVojtěch Pavluch1
Estimated H-index: 1
Abstract The mitochondrion owns an autonomous genome. Double-stranded circular mitochondrial DNA (mtDNA) is organized in complexes with a packing/stabilizing transcription factor TFAM, having multiple roles, and proteins of gene expression machinery in structures called nucleoids . From hundreds to thousands nucleoids exist distributed in the matrix of mitochondrial reticulum network. A single mtDNA molecule contained within the single nucleoid is a currently preferred but questioned model. Neve...
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Silvia Cerri10
Estimated H-index: 10
,
Chiara Milanese4
Estimated H-index: 4
,
Pier G. Mastroberardino23
Estimated H-index: 23
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Mahmoud Ahmed4
Estimated H-index: 4
(Yangzhou University),
Ahmed Kamel Elsayed2
Estimated H-index: 2
(Suez Canal University)
+ 5 AuthorsBichun Li7
Estimated H-index: 7
(Yangzhou University)
Abstract Large bone defects and bone loss after fractures remain significant challenges for orthopedic surgeons. Our study aims to find an available, applicable and biological treatment for bone regeneration overcoming the limitations in ESC/iPSC technology. We directly reprogrammed the mouse embryonic fibroblast (MEF) into osteoblast cells using different combinations of Yamanaka factors with human lim mineralization protein-3 (hLMP-3). LMP is an intracellular LIM-domain protein acting as an ef...
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Pamela Lorenzi5
Estimated H-index: 5
(University of Verona),
A. Sangalli (University of Verona)+ 4 AuthorsMaria Grazia Romanelli15
Estimated H-index: 15
(University of Verona)
Abstract Regulation of alternative splicing events is an essential step required for the expression of functional cytoskeleton and sarcomere proteins in cardiomyocytes. About 3% of idiopathic dilated cardiomyopathy cases present mutations in the RNA binding protein RBM20, a tissue specific regulator of alternative splicing. Transcripts expressed preferentially in skeletal and cardiac muscle, including TTN , CAMK2D , LDB3 , LMO7 , PDLIM3 , RTN4 , and RYR2, are RBM20-dependent splice variants. In ...
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Eduardo Cruz-Ramos1
Estimated H-index: 1
(National Autonomous University of Mexico),
Marina Macías-Silva18
Estimated H-index: 18
(National Autonomous University of Mexico)
+ 1 AuthorsAngeles C. Tecalco-Cruz6
Estimated H-index: 6
(National Autonomous University of Mexico)
Abstract ISG15 (interferon-stimulated gene 15) exists as free ISG15 or conjugated ISG15 modifying its target proteins via ISGylation. Few proteins have been identified and studied as ISGylation targets, and their relevance is not completely clear. Here, we isolated ISG15 from MDA-MB-231 breast cancer cells using immunoprecipitation and identified non-muscle myosin IIA (NMIIA) using mass spectrometry as endogenously associated with ISG15. The identification of NMIIA as an ISG15-interacting protei...
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Wei-Na Yang9
Estimated H-index: 9
(Xi'an Jiaotong University),
Jianshui Zhang9
Estimated H-index: 9
(Xi'an Jiaotong University)
+ 5 AuthorsYi-Hua Qian12
Estimated H-index: 12
(Xi'an Jiaotong University)
Abstract Endoplasmic reticulum (ER) stress caused by β-amyloid protein (Aβ) may play an important role in the pathogenesis of Alzheimer disease (AD). Our previous data have indicated that tanshinone IIA (tan IIA) protected primary neurons from Aβ induced neurotoxicity. To further explore the neuroprotection of tan IIA, here we study the effects of tan IIA on the ER stress response in oligomeric Aβ 1-42 (oAβ 1-42 )-induced SH-SY5Y cell injury. Our data showed that tan IIA pretreatment could incre...
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