The International Journal of Biochemistry & Cell Biology
Papers 5406
1 page of 541 pages (5,406 results)
Abstract Cytochrome c (Cytc)1is a cellular life and death decision molecule that regulates cellular energy supply and apoptosis through tissue specific post-translational modifications. Cytc is an electron carrier in the mitochondrial electron transport chain (ETC) and thus central for aerobic energy production. Under conditions of cellular stress, Cytc release from the mitochondria is a committing step for apoptosis, leading to apoptosome formation, caspase activation, and cell death. Recently,...
Abstract MiR-222 and miR-126 are associated with asbestos exposure and the ensuing malignancy, but the mechanism(s) of their regulation remain unclear. We evaluated the mechanism by which asbestos regulates miR-222 and miR-126 expression in the context of cancer etiology. An ‘in vitro’ model of carcinogen-induced cell transformation was used based on exposing bronchial epithelium BEAS-2B cells to three different carcinogens including asbestos. Involvement of the EGFR pathway and the role of epig...
#1Qian Ma (Fudan University)H-Index: 1
#2Jinyan Kai (Fudan University)H-Index: 1
Last.Renquan Lu (Fudan University)H-Index: 9
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Abstract Drug resistance and recurrence are significant contributors to the poor prognosis of serous ovarian cancer (SOC). Radiotherapy is primarily used for the treatment of cancer recurrence; however, it is rarely applied in cases of SOC. Ku86, also known as XRCC5(X-ray repair cross complementing 5), has rarely been reported in the radiotherapy of SOC. Therefore, this study aimed to investigate the role of Ku86 in the development of SOC and in radiotherapy sensitivity induced by X-ray. In vitr...
#1Yongtao Zhang (Qingdao University)H-Index: 1
#2Huimin Ding (Nanjing Medical University)
Last.Changyao Wang (Qingdao University)H-Index: 2
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Abstract The renin-angiotensin system contributes to the pathogenesis of rheumatoid arthritis, but that the mechanism is unclear. This study aims to investigate the effect of angiotensin II (Ang II) on osteogenic differentiation of synoviocytes and the underlying mechanism. Ang II was showed to inhibite osteogenic differentiation of synoviocytes, which was mitigated by a Dickkopf-1 (DKK-1) inhibitor. DKK-1 was upregulated by Ang II, which was weakened by the Ang II type 1 receptor (AT1R) blocker...
#1Xingxing Li (Nanjing Medical University)
#2Jingyun Li (Nanjing Medical University)
Last.Zhu-yin Qian (Nanjing Medical University)
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Abstract Backgrounds/Aims Pancreatic cancer is a digestive system tumour disease with a notably poor prognosis and a 5-year survival rate of less than 10%. In recent years, peptide drugs have shown great clinical value in antitumour applications. We aim to identify differentially expressed peptides by using peptidomics techniques to explore the mechanisms involved in the development and pathology of pancreatic cancer. Methods We performed peptidomic analysis of pancreatic cancer and paired parac...
#1Jt Cairns (University of Nottingham)
#2Anthony Habgood (University of Nottingham)H-Index: 8
Last.Amanda L. Tatler (University of Nottingham)H-Index: 11
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Abstract ETS domain-containing protein-1 (ELK1) is a transcriptional repressor important in regulating αvβ6 integrin expression. αvβ6 integrins activate the profibrotic cytokine Transforming Growth Factor β1 (TGFβ1) and are increased in the alveolar epithelium in idiopathic pulmonary fibrosis (IPF). IPF is a disease associated with aging and therefore we hypothesised that aged animals lacking Elk1 globally would develop spontaneous fibrosis in organs where αvβ6 mediated TGFβ activation has been ...
#1Sara Khademi (MUMS: Mashhad University of Medical Sciences)H-Index: 4
#2Saeed Sarkar (Tehran University of Medical Sciences)H-Index: 16
Last.Hossein Ghadiri (Tehran University of Medical Sciences)H-Index: 7
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#1Li Pan (University of Electronic Science and Technology of China)
#2Yi Li (University of Electronic Science and Technology of China)H-Index: 68
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Abstract Background Colorectal cancer (CRC) ranks the third among all common malignancy worldwide. Long noncoding RNAs (lncRNAs) have been demonstrated as implicated in CRC, but the roles of many lncRNAs in CRC remain unclear. Exploration of lncRNA TRMP2-AS and its nearby gene in CRC progress was the focus of current study. Methods The expression of TRPM2-AS and its nearby mRNA TRPM2 was measured by using RT-qPCR. The protein levels of TRPM2 and TAF15 were determined using western blot. Cell pro...
#1Amir Tajbakhsh (Shiraz University of Medical Sciences)
#2Petri T. KovanenH-Index: 67
Last.Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 59
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Abstract During the growing process of the atherosclerotic lesions, lipid-filled macrophage foam cells form, accumulate, and ultimately undergo apoptotic death. If the apoptotic foam cells are not timely removed, they may undergo secondary necrosis, and form a necrotic lipid core which renders the plaque unstable and susceptible to rupture. Therefore, the non-lipid-filled fellow macrophages, as the main phagocytic cells in atherosclerotic lesions, need to effectively remove the apoptotic foam ce...
#1Ling Wei (Sichuan University)H-Index: 5
#2Qiuying Liu (Sichuan University)H-Index: 3
Last.Yang Qin (Sichuan University)H-Index: 9
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Abstract The epigenetic silencing mechanism of suppressor 3 of cytokine signaling (SOCS3) in cancers has not been fully elucidated. Polycomb repressive complexes 2 (PRC2), an important epigenetic regulatory factors, exerts a critical role in repressing the initial phase of gene transcription. Whether PRC2 participates the down- regulation of SOCS3 in Hepatocellular carcinoma (HCC) remains unclear and how does PRC2 be recruited target gene still needs to explore. In this study, Using TCGA HCC dat...
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Molecular biology
Cancer research
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