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Journal of Biotechnology
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3.16
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Papers 14100
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Last.Eung-Ji Lee (Hanyang University)H-Index: 6
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Abstract Exenatide, a synthetic version of exendin-4, is a glucagon-like peptide-1 receptor agonist (GLP-1RA) used for treating diabetes, but its relatively short half-life is a major disadvantage. In this study, we attempted residue-specific mono-PEGylation to the middle of the amino acid backbone to extend its in vivo half-life. Exenatide was point-mutated from Lys to Cys at the 12th residue to yield a variant (K12C), and PEG-maleimide of varying molecular weights (MW) (5, 10, 20, 40 kD) was s...
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#1Aly Derbalah (Kafrelsheikh University)H-Index: 2
#2Mohsen Mohamed Elsharkawy (Kafrelsheikh University)H-Index: 8
Abstract This study was carried out to fabricate nickel oxide nanostructures (NONS) and to evaluate its ability to control Cucumber mosaic virus (CMV) by direct antiviral activity as well as induction of systemic resistance in treated cucumber plants. The efficacy of nickel oxide nanostructures for control CMV in cucumber plants was biologically evaluated by a reduction in disease severity, reduction in CMV accumulation and expression of regulatory and defense-related genes. Cucumber plants trea...
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#1Kazem Yarizadeh (UI: University of Isfahan)
#2Mandana Behbahani (UI: University of Isfahan)H-Index: 10
Last.Abdollah Noorbakhsh (UI: University of Isfahan)H-Index: 17
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Abstract Carcinoembryonic antigen (CEA), a highly glycosylated protein, overexpresses in many cancers. In this study, computational methods were used to optimize CEA aptamers. Experimental evaluvation of selected aptamers were conducted through electrochemical impedance spectroscopy. After two and three-dimensional structure modeling, the complexes of twelve reported aptamers against CEA were simulated using the ZDOCK server. Based on docking scores, two aptamer sequences (CSR59 and CSR57.1) wer...
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#1Macarena Siri (CONICET: National Scientific and Technical Research Council)H-Index: 4
#2Mariano Grasselli (CONICET: National Scientific and Technical Research Council)H-Index: 6
Last.Silvia del Valle Alonso (CONICET: National Scientific and Technical Research Council)H-Index: 12
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Abstract Protein nanoparticle designing at the nanoscale is challenging because of protein vulnerability to chemical and physical degradation during processing and biodistribution. We present a crosslinked gamma irradiated albumin-based nanoparticle as a potential drug delivery system. The focus was set on the study of the nanoparticle under adverse experimental conditions: different pH values, SDS, tween 80 and urea. The albumin-based nanoparticle was also tested against time stabilityand ionic...
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#1Carolina Ruiz (UCD: University College Dublin)H-Index: 1
#2Shane T. Kenny (UCD: University College Dublin)H-Index: 13
Last.Kevin E. O’ Connor (UCD: University College Dublin)H-Index: 3
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Abstract Biodegradable and biocompatible polymers polyhydroxyalkanoates (PHAs) have a wide range of applications from packaging to medical. For the production of PHA at scale it is necessary to develop a high productivity bioprocess based on the use of a cheap substrate. The objective of the current study was to develop a high cell density bioreactor-based process for the production of medium chain length polyhydroxyalkanoate (mclPHA) with waste cooking oil as the sole carbon and energy source. ...
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#1Aikaterini Papazi (UoC: University of Crete)H-Index: 8
#2Ioannis G. Pappas (UoC: University of Crete)H-Index: 1
Last.Kiriakos Kotzabasis (UoC: University of Crete)H-Index: 21
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Abstract Olive oil mill wastewater (OMW) is a significant pollutant in the Mediterranean region. In the present contribution, we showed clearly that microorganisms (microalgae and OMW-microflora) activated the biodegradation of OMW-phenolics and produced a high yield of hydrogen (H2). In a closed incubation system, the appropriate adjustment of OMW-pH leads to the establishment of anoxic conditions through the oxygen consumption of microorganisms during the first incubation day. The biodegradati...
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#1Peter-Leon Hagedoorn (TU Delft: Delft University of Technology)H-Index: 22
Abstract The tungsten containing Aldehyde:ferredoxin oxidoreductases (AOR) offer interesting opportunities for biocatalytic approaches towards aldehyde oxidation and carboxylic acid reduction. The hyperthermophilic archaeon Pyrococcus furiosus encodes five different AOR family members: glyceraldehyde-3-phosphate oxidoreductase (GAPOR), aldehyde oxidoreductase (AOR), and formaldehyde oxidoreductase (FOR), WOR4 and WOR5. GAPOR functions as a glycolytic enzyme and is highly specific for the substra...
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#1Kiyohiko Nakasaki (TITech: Tokyo Institute of Technology)H-Index: 26
#2Mitsuhiko Koyama (TITech: Tokyo Institute of Technology)H-Index: 6
Last.Jo Fujita (TITech: Tokyo Institute of Technology)
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Abstract Changes in the microbial community were investigated during the acclimation process of anaerobic digestion while treating synthetic lipid-rich wastewater, which comprised of glucose, acetic acid, lactic acid, and soybean oil. The oil content in the synthetic wastewater was increased successively from 0% to 25% and finally to 50% of the total carbon content, to clarify the effect of substrate type change from easily degradable organic materials to lipid. The oil decomposition-associated ...
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#1Wei-Hung Hung (TMU: Taipei Medical University)
#2Jia-Huei Zheng (TMU: Taipei Medical University)
Last.Er-Chieh Cho (TMU: Taipei Medical University)
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Abstract Colorectal cancer is a leading cause of death in the world. Despite the progress in therapeutic development, there are still challenges in clinical practice. Nanomedicine has emerged as a solution to enhance traditional therapy. Gold nanoparticles (AuNP) have been demonstrated as potential appliance in treating cancers, yet few studies investigated the capacity of biopolymer-conjugated AuNP in colon cancer as well as examined the system in both cancer cell line and animal models. In thi...
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#1Yuxiao Feng (Tianjin University of Science and Technology)H-Index: 2
#2Le Zhong (Tianjin University of Science and Technology)H-Index: 1
Last.Jiandong Cui (Tianjin University of Science and Technology)H-Index: 15
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Abstract Zeolitic imidazole frameworks (ZIFs) with tunable pore sizes and high surface areas have recently used as an effective support for immobilizing enzymes. However, the instability in the aqueous acidic environment has limited their practical applications in some cases. In this work, we develop a novel catalase/ZIFs composite with mesoporous silica shell (mSiO2@CAT/ZIFs) via co-precipitation, and controlled self-assembly of silanes. During preparation, the cetyltrimethylammonium bromide in...
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