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Analytical and Bioanalytical Chemistry
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#2Julian Kager (TU Wien: Vienna University of Technology)H-Index: 5
Last. Markus BrandstetterH-Index: 12
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Real-time measurements and adjustments of critical process parameters are essential for the precise control of fermentation processes and thus for increasing both quality and yield of the desired product. However, the measurement of some crucial process parameters such as biomass, product, and product precursor concentrations usually requires time-consuming offline laboratory analysis. In this work, we demonstrate the in-line monitoring of biomass, penicillin (PEN), and phenoxyacetic acid (POX) ...
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#1Sabrina Metze (Leibniz University of Hanover)
Last. Marek HoehseH-Index: 3
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Viable cell concentration (VCC) is one of the most important process attributes during mammalian cell cultivations. Current state-of-the-art measurements of VCC comprise offline methods which do not allow for continuous process data. According to the FDA’s process analytical technology initiative, process monitoring and control should be applied to gain process understanding and to ensure high product quality. In this work, the use of an inline capacitance probe to monitor online VCCs of a mamma...
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#1Niharika Budholiya (IITD: Indian Institute of Technology Delhi)
#2Souhardya Roy (IITD: Indian Institute of Technology Delhi)
Last. Anurag S. Rathore (IITD: Indian Institute of Technology Delhi)H-Index: 30
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Aggregates are widely accepted to be a critical quality attribute (CQA) for biotherapeutics and believed to impact product immunogenicity. Monitoring of aggregates is typically performed using multiple orthogonal tools as any single tool is unable to offer comprehensive characterization of aggregate species over the entire size and morphology range that they can exist in. Researchers have attempted to categorize monoclonal antibody (mAb) aggregates into six classes based on their respective phys...
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#1Katharina Dahlmann (Leibniz University of Hanover)
#2Christoph Busse (Leibniz University of Hanover)H-Index: 3
Last. Thomas Scheper (Leibniz University of Hanover)H-Index: 37
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In a biotechnological process, standard monitored process variables are pH, partial oxygen pressure (pO2), and temperature. These process variables are important, but they do not give any information about the metabolic activity of the cell. The ISICOM is an in situ combi-sensor that is measuring the cell-specific oxygen uptake rate (qOUR) online. This variable allows a qualitative judgement of metabolic cell activity. The measuring principle of the ISICOM is based on a volume element enclosed i...
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#1Christoph Herwig (TU Wien: Vienna University of Technology)H-Index: 26
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#1Julia Flesch (University of Osnabrück)H-Index: 1
#2Marie Kappen (University of Osnabrück)
Last. Jacob Piehler (University of Osnabrück)H-Index: 50
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Localized surface plasmon resonance (LSPR) detection offers highly sensitive label-free detection of biomolecular interactions. Simple and robust surface architectures compatible with real-time detection in a flow-through system are required for broad application in quantitative interaction analysis. Here, we established self-assembly of a functionalized gold nanoparticle (AuNP) monolayer on a glass substrate for stable, yet reversible immobilization of Histidine-tagged proteins. To this end, on...
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The intestinal microbiome plays an important role in human health and disease and fecal materials reflect the microbial activity. Thus, analysis of fecal metabolites provides insight in metabolic interactions between gut microbiota and host organism. In this work, we applied flow injection analysis coupled to Fourier transform mass spectrometry (FIA-FTMS) to identify and quantify lipid species in human fecal samples. Fecal homogenates were subjected to lipid extraction and analyzed by FIA-FTMS. ...
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#1Timo Koehler (University of Duisburg-Essen)
#2Imke Ackermann (University of Duisburg-Essen)
Last. Oliver J. Schmitz (University of Duisburg-Essen)H-Index: 25
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Cystic fibrosis (CF) is an autosomal recessive inherited disease which leads to a production of thickened mucus in the airways. These conditions are conducive to poly-microbial infections, like chronic lung infection, in which Pseudomonas aeruginosa (P. aeruginosa) is the major pathogenic bacterium colonizing CF lungs at the end of the lifetime of CF patients. This in vitro study uses a P. aeruginosa biofilm model under partly cystic fibrosis conditions, with a sampling of volatile extracellular...
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Analytical chemistry
Detection limit
Mass spectrometry
Chemistry
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