Progress in Biophysics & Molecular Biology
Papers 1813
1 page of 182 pages (1,813 results)
#1Qian Wu (University of Cambridge)H-Index: 11
#2Shikang Liang (University of Cambridge)H-Index: 2
Last.Tom L. Blundell (University of Cambridge)H-Index: 98
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Abstract DNA double-strand breaks (DSBs), generated by ionizing radiation, reactive oxygen species and DNA replication across nicks, are the most severe DNA damage in eukaryotic cells. Non-Homologous End Joining repairs DNA double-strand breaks directly without a template and so can take place at any point in the cell cycle. Ku70/80 heterodimers rapidly assemble around broken DNA ends, allowing DNA-PKcs, the catalytic subunit of DNA-dependent protein kinase, to be recruited and facilitating syna...
1 CitationsSource
#1Albino Bacolla (University of Texas MD Anderson Cancer Center)H-Index: 24
#2Zu Ye (University of Texas MD Anderson Cancer Center)H-Index: 1
Last.John A. Tainer (University of Texas MD Anderson Cancer Center)H-Index: 106
view all 4 authors...
Abstract A hallmark of cancer is genomic instability, which can enable cancer cells to evade therapeutic strategies. Here we employed a computational approach to uncover mechanisms underlying cancer mutational burden by focusing upon relationships between 1) translocation breakpoints and the thousands of G4 DNA-forming sequences within retrotransposons impacting transcription and exemplifying probable non-B DNA structures and 2) transcriptome profiling and cancer mutations. We determined the loc...
2 CitationsSource
#1Daniel J. Saltzberg (UCSF: University of California, San Francisco)H-Index: 5
#2Morgan Hepburn (U of C: University of Calgary)H-Index: 3
Last.Andrej Sali (UCSF: University of California, San Francisco)H-Index: 97
view all 7 authors...
Abstract X-ray crystallography and electron microscopy maps resolved to 3–8 A are generally sufficient for tracing the path of the polypeptide chain in space, while often insufficient for unambiguously registering the sequence on the path (i.e., threading). Frequently, however, additional information is available from other biophysical experiments, physical principles, statistical analyses, and other prior models. Here, we formulate an integrative approach for sequence assignment to a partial ba...
#1Philippe Frit (University of Toulouse)H-Index: 7
#2Virginie Ropars (Université Paris-Saclay)H-Index: 10
Last.Patrick Calsou (University of Toulouse)H-Index: 10
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Abstract In vertebrates, double-strand breaks in DNA are primarily repaired by Non-Homologous End-Joining (NHEJ). The ring-shaped Ku heterodimer rapidly senses and threads onto broken DNA ends forming a recruiting hub. Through protein-protein contacts eventually reinforced by protein-DNA interactions, the Ku-DNA hub attracts a series of specialized proteins with scaffolding and/or enzymatic properties. To shed light on these dynamic interplays, we review here current knowledge on proteins direct...
2 CitationsSource
Abstract Tuberculosis incidence is projected to decline at too slow a rate to meet the targets set at the UN high level meeting on ending tuberculosis, convened in New York in 2018. To understand the causes of the slow progress in tuberculosis control, the Bill and Melinda Gates Foundation supported a patient-pathway analysis that identified significant gaps with patients being “lost” at all points along the care cascade. Although each country differed in the reasons for failure, some commonalit...
#1Domagoj Baretić (LMB: Laboratory of Molecular Biology)H-Index: 4
Last.C. PhillipsH-Index: 7
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Abstract ATM, ATR and DNA-PKCs are key effectors of DNA Damage response and have been extensively linked to tumourigenesis and survival of cancer cells after radio/chemotherapy. Despite numerous efforts, the structures of these proteins remained elusive until very recently. The resolution revolution in Cryo-EM allowed for molecular details of these proteins to be seen for the first time. Here we provide a comprehensive review of the structures of ATM, ATR and DNA-PKcs and their complexes and exp...
1 CitationsSource
Abstract Biomolecules can be synthesized in interstellar ice grains subject to UV radiation and cosmic rays. I show that on time scales of ≳ 10 6 years, these processes lead to the formation of large percolation clusters of organic molecules. Some of these clusters would have ended up on proto-planets where large, loosely bound aggregates of clusters (superclusters) would have formed. The interior regions of such superclusters provided for chemical micro-environments that are filtered versions o...
#1Noa Lamm (Children's Medical Research Institute)H-Index: 1
#2Samuel Rogers (Children's Medical Research Institute)H-Index: 1
Last.Anthony J. Cesare (Children's Medical Research Institute)H-Index: 21
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Abstract DNA replication plays a central role in genome health. Deleterious alteration of replication dynamics, or “replication stress”, is a key driver of genome instability and oncogenesis. The replication stress response is regulated by the ATR kinase, which functions to mitigate replication abnormalities through coordinated efforts that arrest the cell cycle and repair damaged replication forks. mTOR kinase regulates signaling networks that control cell growth and metabolism in response to e...
1 CitationsSource
#1Albino Bacolla (University of Texas MD Anderson Cancer Center)H-Index: 24
#2John A. Tainer (University of Texas MD Anderson Cancer Center)H-Index: 106
#1Chelsea E. Cunningham (U of S: University of Saskatchewan)H-Index: 3
#2Mackenzie J. MacAuley (U of S: University of Saskatchewan)H-Index: 1
Last.Franco J. Vizeacoumar (U of S: University of Saskatchewan)H-Index: 20
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Abstract Genomic instability, and more specifically chromosomal instability (CIN), arises from a number of processes that are defective in cancer, such as aberrant mitotic cell division, replication stress, defective DNA damage repair, and ineffective telomere maintenance. CIN is an emerging hallmark of cancer that contributes to tumor heterogeneity through increased rates of genetic alterations. As genetic heterogeneity within a single tumor and between tumors is a key challenge leading to trea...
3 CitationsSource
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Cell biology