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Journal of Chromatography A
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3.86
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#1Till Briskot (KIT: Karlsruhe Institute of Technology)H-Index: 4
#2Tobias HahnH-Index: 9
Last.Jürgen Hubbuch (KIT: Karlsruhe Institute of Technology)H-Index: 31
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Abstract Mechanistic modeling of protein adsorption has gained increasing importance in the development of ion-exchange (IEX) chromatography processes. The most common adsorption models use a stoichiometric representation of the adsorption process based on the law of mass action. Despite the importance of these models in model-based development, the stoichiometric representation of the adsorption process is not accurate for the description of long-range electrostatic interactions in IEX chromato...
Abstract This paper describes the method validation for the simultaneous determination of seven cysteinylated aldehydes, i.e. 2-substituted 1,3-thiazolidines-4-carboxylic acids, using ultra-high-performance liquid chromatography-mass spectrometry (UHPLC–MS). Authentic reference compounds were first synthesized for identification and quantification purposes. Moreover, nuclear magnetic resonance (1H NMR and 13C NMR) was applied for verification of their structure, while ultra-high-performance liqu...
Abstract Small organic acids are widely used within the pharmaceutical industry but can be difficult to analyse. Ion chromatography is a suitable technique for the analysis of these acids but method development can be hindered as mass spectrometry is not often used as a detector; this means that peak tracking and peak purity cannot be performed. The authors report method development for the analysis of 2-butynoic acid, where by using electrospray ionisation mass spectrometry, peak purity was inv...
#1Benjamin Savareear (University of Liège)H-Index: 2
#2Juan Escobar-Arnanz (University of Liège)
Last.Jean-François Focant (University of Liège)H-Index: 32
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Abstract An analytical methodology based on thermal desorption and comprehensive two-dimensional gas chromatography with dual time-of-flight mass spectrometry and flame ionization detection (TD-GC × GC-TOFMS/FID) has been developed for non-target analysis of volatile organic compounds (VOCs). The technique was optimised for the measurement of the VOC content of the particulate phase (PP) fraction of aerosols produced by a tobacco heating product (THP1.0) and 3R4F mainstream tobacco smoke (MTS). ...
#1Tatiane Lima Amorim (UFJF: Universidade Federal de Juiz de Fora)
#2Lucas M. Duarte (UFJF: Universidade Federal de Juiz de Fora)H-Index: 3
Last.Pilar Gómez-Cortés (CSIC: Spanish National Research Council)H-Index: 15
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Abstract Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are essential omega-3 fatty acids (FA) in human nutrition. Dietary supplements containing these FA are available in the market and there is a need to assess their quality to prevent frauds. The purpose of this work was to optimize and validate a fast capillary electrophoresis (CE) method to determine EPA and DHA content in marine oils omega-3 supplements. Sample preparation comprised only a saponification step and analysis time ...
#1Gábor Tóth (MTA: Hungarian Academy of Sciences)
#2Tanja Panić-Janković (Medical University of Vienna)H-Index: 2
Last.Goran Mitulovic (Medical University of Vienna)H-Index: 13
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Abstract Reversed-phase chromatography is the most common technique for separation of tryptic peptides. In this short communication, we describe the optimization of sample loading and separation parameters for a novel micromachined column and provide a detailed description on the performance and reproducibility of this separation system. Tryptic digest of a mixture of seven proteins with diverse mass and isoelectric point was used as a test sample. The methods developed and used are straight-for...
#1Manuela Cortese (University of Camerino)H-Index: 7
#2Maria Rosa Gigliobianco (University of Camerino)H-Index: 3
Last.Piera Di Martino (University of Camerino)H-Index: 23
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Abstract Phenolic compoundsphenolic compoundsphenolic compoundspresent in several kind of craft beers, corresponding worts, ingredients and spent products was performed by LC-MS/MS. The dilution 1:2 of the sample with the mobile phase gave the best results, offering a very fast and simple method to reduce the matrix effect. A validated method was applied to six different types of craft beers, their worts, starting and spent products, such as barley malts and barley husks, starting hops and spent...
#1María B. Anzardi (CONICET: National Scientific and Technical Research Council)
#2Juan A. Arancibia (CONICET: National Scientific and Technical Research Council)H-Index: 18
Last.Alejandro C. Olivieri (CONICET: National Scientific and Technical Research Council)H-Index: 43
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Abstract Parallel factor analysis 2 (PARAFAC2) is still being advocated for the processing of second-order chromatographic-spectral data, both for qualitative and quantitative applications. However, neither classical PARAFAC2 nor the newly developed flexible non-negative NN-PARAFAC2 version can adequately model these data in a general situation. In quantitative analysis, considerable bias may result in the estimation of analyte concentrations, due to the fact that both PARAFAC2 models apply an a...
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