Molecular BioSystems
Papers 3105
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#1Arup Panda (Bose Institute)H-Index: 5
#2Debarun Acharya (Bose Institute)H-Index: 2
Last.Tapash Chandra Ghosh (Bose Institute)H-Index: 20
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Expression level provides important clues about gene function. Previously, various efforts have been undertaken to profile human genes according to their expression level. Intrinsically disordered proteins (IDPs) do not adopt any rigid conformation under physiological conditions, however, are considered as an important functional class in all domains of life. Based on a human tissue-averaged gene expression level, previous studies showed that IDPs are expressed at a lower level than ordered glob...
#1Mohanraj Krishnan (University of Auckland)H-Index: 3
#2John F. Thompson (University of Auckland)H-Index: 96
Last.Andrew N. Shelling (University of Auckland)H-Index: 35
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Childhood obesity is a public health problem, which is associated with a long-term increased risk of cardiovascular disease and premature mortality. Several gene variants have previously been identified that have provided novel insights into biological factors that contribute to the development of obesity. As obesity tracks through childhood into adulthood, identification of the genetic factors for obesity in early life is important. The objective of this study was to identify putative associati...
#1Junwei Fang (SHU: Shanghai University)H-Index: 6
#2Liping Wang (Fudan University)H-Index: 1
Last.Yongyu Zhang (SHU: Shanghai University)H-Index: 7
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The major obstacle for the development of targeted therapies is the lack of pharmacodynamic (PD) biomarkers to provide an early readout of biological activities. As the modulation of metabolites may reflect the biological changes occurring in the targets, metabolomics is promising to be an efficient way to explore PD biomarkers. In the present study, a liver fibrosis rat model was established by intraperitoneal injection of CCl4 twice weekly for 6 weeks, the treatment of total aglycone extracts ...
#1Taiyi Wang (Tianjin University of Traditional Chinese Medicine)H-Index: 3
#2Ming Lu (Tianjin University of Traditional Chinese Medicine)H-Index: 1
Last.Yan Zhu (Tianjin University of Traditional Chinese Medicine)H-Index: 18
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Correction for ‘An integrated anti-arrhythmic target network of a Chinese medicine compound, Wenxin Keli, revealed by combined machine learning and molecular pathway analysis’ by Taiyi Wang et al., Mol. BioSyst., 2017, 13, 1018–1030.
#1Bikash Ranjan Sahoo (Osaka University)H-Index: 8
#2Toshimichi Fujiwara (Osaka University)H-Index: 25
Understanding the downstream signaling mechanism of sensory rhodopsin and its cognate transducer complex (srII–htrII) has long been a challenge in the field of photoreceptor research. Here, an integration of all-atom and coarse-grained (CG) molecular dynamics (MD) simulations in different srII–htrII complex states is carried out. It is shown that the cytoplasmic four-helix HAMP dimer gives rise to a gear-box model interaction with discrete hydrophobic packing in Natronomonas pharaonis (Np). Stru...