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European Journal of Cancer
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#1Antonin Levy (Université Paris-Saclay)H-Index: 6
#2Anna Dorothea Wagner (UNIL: University of Lausanne)H-Index: 7
Last. Michel Ducreux (Université Paris-Saclay)H-Index: 83
view all 15 authors...
Abstract Malignant dysphagia is the most common symptom in advanced oesogastric cancers patients. Relief of dysphagia allows quality of life improvement, nutritional replenishment and potentially improves prognosis. Chemotherapy alone is effective and should be prioritised in patients with metastatic disease a good performance status, and its impact on dysphagia should be determined before further interventions are planned. Regarding local treatments, the insertion of a covered self-expandable m...
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#1Loredana Amoroso (Istituto Giannina Gaslini)H-Index: 9
#2Victoria CastelH-Index: 29
Last. Nicolas U. Gerber (Boston Children's Hospital)H-Index: 14
view all 18 authors...
Abstract Background The phase I component of a phase I/II study defined the recommended phase II dose and established the tolerability of nab-paclitaxel monotherapy in paediatric patients with recurrent or refractory solid tumours. The activity and safety of nab-paclitaxel monotherapy was further investigated in this phase II study. Patients and methods Paediatric patients with recurrent or refractory Ewing sarcoma, neuroblastoma or rhabdomyosarcoma received 240 mg/m2 of nab-paclitaxel on days 1...
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#1Roberto MorettoH-Index: 11
#2Salvatore CoralloH-Index: 7
Last. Fotios LoupakisH-Index: 44
view all 25 authors...
Abstract Background Immune-contexture of tumour microenvironment (TME) influences prognosis of colorectal cancer (CRC) patients and can be altered by cytotoxic and targeted agents. Limited data are available regarding the immune-TME of CRC after treatment. Methods An extensive immunohistochemistry evaluation of immunological parameters on tumour cells and TME of colorectal liver metastases from 106 patients who underwent secondary resection, after receiving triplets FOLFOXIRI (5-fluorouracil, ox...
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#1Henry G. Smith (The Royal Marsden NHS Foundation Trust)H-Index: 8
#2Izhar Bagwan (Royal Surrey County Hospital)H-Index: 5
Last. Karen Nugent (University Hospital Southampton NHS Foundation Trust)H-Index: 1
view all 20 authors...
Abstract Ano-uro-genital (AUG) mucosal melanomas are rare cancers associated with poor outcomes and limited evidence-based management. The United Kingdom AUG mucosal melanoma guideline development group used an evidence-based systematic approach to make recommendations regarding the diagnosis, treatment and surveillance of patients diagnosed with AUG mucosal melanomas. The guidelines were sent for international peer review, and are accredited by The National Institute for Health and Clinical Exc...
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#1K. Sies (Heidelberg University)H-Index: 1
#2Julia K. Winkler (Heidelberg University)H-Index: 12
Last. Holger A. Haenssle (Heidelberg University)H-Index: 19
view all 10 authors...
Abstract Background Convolutional neural networks (CNNs) have shown a dermatologist-level performance in the classification of skin lesions. We aimed to deliver a head-to-head comparison of a conventional image analyser (CIA), which depends on segmentation and weighting of handcrafted features, to a CNN trained by deep learning. Methods Cross-sectional study using a real-world, prospectively acquired, dermoscopic dataset of 1981 skin lesions to compare the diagnostic performance of a market-appr...
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#1Yihui Du (UMCG: University Medical Center Groningen)H-Index: 1
#2Grigory Sidorenkov (UMCG: University Medical Center Groningen)H-Index: 8
Last. Geertruida H. de Bock (UMCG: University Medical Center Groningen)H-Index: 37
view all 7 authors...
Abstract Background Lung cancer screening with low-dose computed tomography (LDCT) reduces lung cancer mortality. The aim of this study was to evaluate the cost-effectiveness of lung cancer screening with LDCT in a high-risk population. Methods The study used an adapted microsimulation model in a cohort of Dutch heavy smokers for a lifetime horizon from a health insurance perspective. The main outcomes included average cost-effectiveness ratio (ACER), incremental cost-effectiveness ratio (ICER) ...
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#1Anna S. Berghoff (Medical University of Vienna)H-Index: 30
#2Christoph Wippel (Medical University of Vienna)
Last. Brigitte Gatterbauer (Medical University of Vienna)H-Index: 13
view all 18 authors...
Abstract Background Several preclinical and epidemiologic studies have indicated tumour-promoting effects of thyroid hormones (THs). However, very limited knowledge exists on the prognostic impact of thyroid function in metastatic cancer. Methods We compiled a discovery cohort of 1692 patients with newly diagnosed brain metastases (BMs) of solid cancers treated at the Medical University of Vienna and an independent validation cohort of 191 patients with newly diagnosed BMs treated at the Univers...
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