Vitamins and Hormones Series
Papers 1433
1 page of 144 pages (1,433 results)
#1Siladitya Padhi (Tata Consultancy Services)H-Index: 5
#2U. Deva Priyakumar (IIIT-H: International Institute of Information Technology, Hyderabad)H-Index: 20
Abstract The transport of water through aquaporins is a dynamic process that involves rapid movement of a chain of water molecules through the pore of the aquaporin. Structures of aquaporins solved using X-ray crystallography have provided some insights into how water is transported through these channels, and how certain structural features of the pore might help exclude other solutes from passing through the pore. However, such techniques provide only a static picture, and a dynamic picture of...
1 CitationsSource
#1Antonio Pérez-Pérez (University of Seville)H-Index: 14
#2Teresa Vilariño-García (University of Seville)H-Index: 5
Last. Victor Sánchez Margalet (University of Seville)H-Index: 2
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Water is the major component of cells and tissues. The fetal body consists of about 70-90% water and its fluid balance is dependent on the mother. In fact, abortion, premature birth, amniotic fluid volume abnormality, malformation and fetal growth restrictions might result when the homeostasis of the maternal-fetal fluid exchange is disrupted. Thus, maternal-fetal fluid balance is critical during pregnancy. In this sense, several mechanisms, including aquaporins (AQPs) have been reported to play...
#1Wayne J. Kuenzel (UA: University of Arkansas)H-Index: 19
#2Seong W. Kang (UA: University of Arkansas)H-Index: 9
Last. Alexander JurkevichH-Index: 5
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Abstract The regulation of stress in birds includes a complex interaction of neural systems affecting the hypothalamic-pituitary-adrenal (HPA) axis. In addition to the hypothalamic paraventricular nucleus, a structure called the nucleus of the hippocampal commissure likewise affects the output of pituitary stress hormones and appears to be unique to avian species. Within the anterior pituitary, the avian V1a and V1b receptors were found in corticotropes. Based on our studies with central adminis...
#1Don T. Li (Yale University)H-Index: 3
#2Estifanos N. Habtemichael (Yale University)H-Index: 7
Last. Jonathan S. Bogan (Yale University)H-Index: 26
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Abstract The physiological importance of vasopressin inactivation has long been appreciated, but the mechanisms and potential pathophysiologic roles of this process remain active subjects of research. Human Placental Leucine Aminopeptidase (P-LAP, encoded by the LNPEP gene) is an important determinant of vasopressinase activity during pregnancy and is associated with gestational diabetes insipidus and preeclampsia. Insulin-Regulated Aminopeptidase (IRAP), the rodent homologue of P-LAP, is coregu...
#1Martin Spiess (University of Basel)H-Index: 39
#2Nicole Beuret (University of Basel)H-Index: 8
Last. Jonas Rutishauser (University of Basel)H-Index: 17
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Abstract The antidiuretic hormone vasopressin is synthesized as a longer precursor protein. After folding in the endoplasmic reticulum (ER), provasopressin is transported through the secretory pathway, forms secretory granules in the trans-Golgi network (TGN), is processed, and finally secreted into the circulation. Mutations in provasopressin cause autosomal dominant diabetes insipidus. They prevent native protein folding and cause fibrillar, amyloid-like aggregation in the ER, which eventually...
#1Sally A. Mayasich (UMN: University of Minnesota)H-Index: 2
#2Benjamin L. Clarke (UMN: University of Minnesota)H-Index: 13
Abstract We previously characterized the arginine vasotocin receptor sequences in the jawless vertebrate sea lamprey. These gene and protein sequences provide clues to the origins of the various arginine vasopressin and oxytocin receptor family members in jawed vertebrates. However, orthological relationships between the jawless and jawed receptors is unclear. The current work is a closer examination and comparison between these G protein-coupled receptor sequences of the lamprey, the early jawe...
#1Suchun Li (SYSU: Sun Yat-sen University)H-Index: 3
#2Chunling Li (SYSU: Sun Yat-sen University)H-Index: 8
Last. Weidong Wang (SYSU: Sun Yat-sen University)H-Index: 7
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Abstract Water can diffuse freely through the lipid bilayer at a limited rate or by water channel proteins in a rapid speed. Aquaporins (AQPs) are a family of membrane water channel proteins that mainly function as regulators of intracellular and intercellular water flow. They are distributed wildly in specific cell types in multiple organs and tissues. Since the first AQP was identified, 13 AQPs have been characterized in mammals. Structural analysis shows that AQPs are homotetramers with each ...
1 CitationsSource
#1L. González-Dávalos (UNAM: National Autonomous University of Mexico)H-Index: 4
#2Mariana Álvarez-Pérez (UNAM: National Autonomous University of Mexico)
Last. Ofelia Mora (UNAM: National Autonomous University of Mexico)H-Index: 10
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AQP7 is the primary glycerol transporter in white (WAT) and brown (BAT) adipose tissues. There are immediate and quantitatively important actions of cortisone over the expression of AQP7 in murine and human adipocytes. Short-term response (minutes) of cortisone treatment result in an mRNA overexpression in white and brown differentiated adipocytes (between 1.5 and 6 folds). Conversely, long-term response (hours or days) result in decreased mRNA expression. The effects observed on AQP7 mRNA expre...
#1Matteo Tardelli (Medical University of Vienna)H-Index: 1
#1Matteo Tardelli (Medical University of Vienna)H-Index: 7
Last. Thomas M. Stulnig (Medical University of Vienna)H-Index: 35
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Abstract Aquaporins (AQPs) are a family of 13 small trans-membrane proteins, which facilitate shuttling of glycerol, water and urea. The peculiar role of AQPs in glycerol transport makes them attractive targets in metabolic organs since glycerol represents the backbone of triglyceride synthesis. Importantly, AQPs are known to be regulated by various nuclear receptors which in turn govern lipid and glucose metabolism as well as inflammatory cascades. Here, we review the role of AQPs regulation in...
Abstract Human Aquaporin 2 (AQP2) is a membrane-bound water channel found in the kidney collecting duct whose regulation by trafficking plays a key role in regulating urine volume. AQP2 trafficking is tightly controlled by the pituitary hormone arginine vasopressin (AVP), which stimulates translocation of AQP2 residing in storage vesicles to the apical membrane. The AVP-dependent translocation of AQP2 to and from the apical membrane is controlled by multiple phosphorylation sites in the AQP2 C-t...
1 CitationsSource
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