Papers 4201
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#1Ming Yi (Tianjin Medical University General Hospital)
#2Ming-Qi Liu (Tianjin Medical University General Hospital)
Last. Li Yang (Tianjin Medical University General Hospital)H-Index: 8
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Abstract Aims Neuromyelitis optica spectrum disorders (NMOSD) are aquaporin-4 antibody-mediated diseases of the central nervous system. Endothelin-1 (ET-1) is an inflammatory cytokine released by vascular endothelial cells and activated astrocytes. Previous studies have reported the aberrant expressions of cytokines/chemokines in patients diagnosed with NMOSD. However, the serum levels of ET-1 in NMOSD patients remain unknown. The purpose of this study was to measure the serum levels of ET-1 and...
#1Lu ZhangH-Index: 13
#2Thomas HöferH-Index: 48
Last. Loems Ziegler-HeitbrockH-Index: 21
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Abstract Non-classical human monocytes are characterized by high-level expression of cytokines like TNF, but the mechanisms involved are elusive. We have identified miRNAs and CpG-methylation sites that are unique to non-classical monocytes, defined via CD14 and CD16 expression levels. For down-regulated miRNAs that are linked to up-regulated mRNAs the dominant gene ontology term was intracellular signal transduction. This included down-regulated miRNA-20a-5p and miRNA-106b-5p, which both are li...
#1Bishajit Sarkar (JU: Jahangirnagar University)
#2Md. Asad Ullah (JU: Jahangirnagar University)H-Index: 3
Last. Yusha Araf (SUST: Shahjalal University of Science and Technology)H-Index: 2
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Abstract SARS Coronavirus-2 (SARS-CoV-2) pandemic has become a global issue which has raised the concern of scientific community to design and discover a counter-measure against this deadly virus which has caused deaths of numerous infected people upon infection and spreading. To date, no effective vaccine is available which can combat the infection caused by this virus. This study was conducted to design possible epitope-based subunit vaccines against the SARS-CoV-2 virus using the approaches o...
#1Giselle Santos Magalhães (NIST: National Institute of Standards and Technology)H-Index: 5
#2Juliana Fabiana Gregório (NIST: National Institute of Standards and Technology)
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Abstract Asthma is characterized by inflammation, pulmonary remodeling and bronchial hyperresponsiveness. We have previously shown that treatment with angiotensin-(1-7) [Ang-(1-7)] promotes resolution of eosinophilic inflammation and prevents chronic allergic lung inflammation. Here, we evaluated the effect of treatment with the inclusion compound of Ang-(1-7) in hydroxypropyl β-cyclodextrin (HPβCD) given by inhalation on pulmonary remodeling in an ovalbumin (OVA)-induced chronic allergic lung i...
#1Kevin L. Trout (UM: University of Montana)H-Index: 3
#2Andrij Holian (UM: University of Montana)H-Index: 44
Abstract Macrophages fuse into multinucleated giant cells (MGC) in many pathological conditions. Despite MGC correlations with granulomas, their functional contribution to inflammation is relatively unknown. An in vitro mouse model of IL-4-induced bone marrow-derived macrophage fusion and microfiltration were used to generate enriched MGC and macrophage populations. Phenotypes were compared in response to well-known inflammatory stimuli, including lipopolysaccharide and crocidolite asbestos. Sur...
#1Alisa Gruden-Movsesijan (University of Belgrade)H-Index: 11
#2Jelena Drulovic (University of Belgrade)H-Index: 29
Last. Ljiljana Sofronic-Milosavljevic (University of Belgrade)H-Index: 10
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Abstract Helminths, as complex pathogens, possess a large number of different epitopes, some of which may be similar to the epitopes of the host. Besides being the cause for the activation of self-reactive immune cells, molecular mimicry may also be the cause for the expansion of regulatory T cells, crucial for the host tolerance of self-antigens. Amelioration of experimental autoimmune encephalomyelitis (EAE), animal model of multiple sclerosis (MS), caused by Trichinella spiralis infection or ...
#1Asad Ullah (JU: Jahangirnagar University)
#2Bishajit Sarkar (JU: Jahangirnagar University)
Last. Syed Sajidul Islam (JU: Jahangirnagar University)H-Index: 3
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Abstract Ebola virus is a highly pathogenic RNA virus that causes haemorrhagic fever in human. This virus is considered as one of the dangerous viruses in the world with very high mortality rate. To date, no epitope-based subunit vaccine has yet been discovered to fight against Ebola although the outbreaks of this deadly virus took many lives in the past. In this study, approaches of reverse vaccinology were utilized in combination with different tools of immunoinformatics to design subunit vacc...
2 CitationsSource
Abstract Chronic obstructive pulmonary disease (COPD) is a lung inflammatory disease characterized by progressive airflow limitation, chronic respiratory symptoms and frequent exacerbations. There is an unmet need to identify novel therapeutic alternatives beside bronchodilators that prevent disease progression. Levels of both Nitric Oxide (NO) and IL-6 were significantly increased in the plasma of patients in the exacerbation phase (ECOPD, n = 13) when compared to patients in the stable phase (...
#1Charlotte B. Holt (AU: Aarhus University)H-Index: 2
#2I.T. Hoffmann-Petersen (Aarhus University Hospital)
Last. Jakob Appel Østergaard (Aarhus University Hospital)H-Index: 5
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#1J Ferluga (Brunel University London)H-Index: 1
#1Janez FerlugaH-Index: 5
Last. Uday KishoreH-Index: 42
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Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb) infection, remains a major global health emergency. It is estimated that one third of global population are affected, predominantly with latent granuloma form of the disease. Mtb co-evolved with humans, for its obligatory intra-macrophage phagosome habitat and slow replication, balanced against unique mycobacterial innate immunity, which appears to be highly complex. TB is transmitted via cough aerosol Mtb inhalation. Bovine ...
Top fields of study
Molecular biology
Immune system