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Journal of Controlled Release
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7.90
Papers
11433
Papers 11416
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#1Yuan He (UM: University of Macau)
#2Yingmin Liang (HKU: University of Hong Kong)H-Index: 5
Last.Ying Zheng (UM: University of Macau)H-Index: 20
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Abstract Pulmonary delivery of active drugs has been applied for the treatment of obstructive lung diseases, including asthma, chronic obstructive pulmonary disease and cystic fibrosis, for several decades and has achieved progress in symptom management by bronchodilator inhalation. However, substantial progress in anti-inflammation, prevention of airway remodeling and disease progression is limited, since the majority of the formulation strategies focus only on particle deposition, which is ins...
#1Nuphar VeigaH-Index: 3
#2Meir GoldsmithH-Index: 13
Last.Dan PeerH-Index: 34
view all 9 authors...
Abstract Interferon regulatory factor 8 (IRF8) protein plays a critical role in the differentiation, polarization, and activation of mononuclear phagocytic cells. In light of previous studies, we explored the therapeutic potential of IRF8 inhibition as immunomodulatory therapy for inflammatory bowel disease (IBD). To this end, we utilized siRNA-loaded lipid-based nanoparticles (siLNPs) and demonstrated a ∼90% reduction of IRF8 mRNA levels in vitro (PV
#1Peter Boyd ('QUB': Queen's University Belfast)H-Index: 12
#2Bruce Variano (Population Council)H-Index: 3
Last.R. Karl Malcolm ('QUB': Queen's University Belfast)H-Index: 24
view all 7 authors...
Abstract Drug-releasing vaginal rings are torus-shaped devices, generally fabricated from thermoplastics or silicone elastomers, used to administer pharmaceutical drugs to the human vagina for periods typically ranging from three weeks to twelve months. One of the most important product performance tests for vaginal rings is the in vitro release test. Although it has been fifty years since the a vaginal ring device was first described in the scientific literature, and despite seven drug-releasin...
#1Na Ji (Jiangnan University)
#2Yan Hong (Jiangnan University)H-Index: 6
Last.Caiming Li (Jiangnan University)H-Index: 4
view all 6 authors...
Abstract Non-invasive means of insulin administration circumvent some of the inconveniences of injections. Oral administration in particular is convenient, pain-free, and allows favorable glucose homeostasis, but is subject to chemical instability, enzymatic degradation, and poor gastrointestinal absorption. Natural polymeric nanoparticles have emerged as a promising oral delivery system for peptide therapeutics due their safety, biocompatibility, and stability. In this study, self-assembled nan...
#1Yixin Wang (CPU: China Pharmaceutical University)H-Index: 3
#2Ling Ding (UNMC: University of Nebraska Medical Center)
Last.David Oupicky (UNMC: University of Nebraska Medical Center)H-Index: 23
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Abstract Acute lung injury (ALI) and idiopathic pulmonary fibrosis (IPF) are severe lung diseases causing irreversible lung damage and premature death. Both diseases share multiple pathological features, including overexpression of C-X-C chemokine receptor type 4 (CXCR4) and upregulation of plasminogen activator inhibitor-1 (PAI-1). The goal of the present study was to evaluate therapeutic potential of pulmonary treatment with combined inhibition of CXCR4 and PAI-1 in ALI and various disease sta...
#1Sybil Obuobi (NUS: National University of Singapore)H-Index: 4
#2Hilda Kai-Lin Tay (NUS: National University of Singapore)
Last.Pui Lai Rachel Ee (NUS: National University of Singapore)H-Index: 23
view all 7 authors...
Abstract There is growing interest in the development of nucleic acid nanostructures as smart functional materials for applications in drug delivery. Inspired by the diverse physical interactions that exist in nature, crosslinked DNA nanostructures can serve as attractive affinity binding networks that interact with therapeutic cargos or living cells. Herein we report a strategy that addresses the challenges of topical oligopeptide therapy by exploiting high binding affinity between polyanionic ...
#1Seigo Kimura (Hokkaido University)H-Index: 1
#2Ikramy A. Khalil (Assiut University)H-Index: 15
Last.Hideyoshi Harashima (Hokkaido University)H-Index: 61
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Abstract Efficiently delivering plasmid DNA (pDNA) to the spleen is particularly significant for DNA immunization. However, increasing the efficiency of gene expression in spleen cells for achieving a therapeutic effect remains a serious challenge. An ideal spleen-targeted system should avoid liver uptake and should efficiently transfect specific functional spleen cells. Here, we report on pDNA nanocarriers with enhanced transfection in spleen cells driven by synergism between an octaarginine (R...
#1Xinfang Li (ZJU: Zhejiang University)H-Index: 2
#2Qinan Xu (ZJU: Zhejiang University)H-Index: 1
Last.Youxiang Wang (ZJU: Zhejiang University)H-Index: 15
view all 5 authors...
Abstract Transdermal gene therapy is a useful treatment for many skin lesions. By penetrating stratum corneum directly, microneedle patch (MNP) has been widely investigated to improve transdermal gene delivery. However, considering the operability and patience compliance, quick gene release was required after insertion. In this research, by utilizing acidic cutaneous environment, pH-responsive polyelectrolyte multilayers (PEM) were coated on the surface of polycaprolactone (PCL) microneedles by ...
#1Maximilian Sager (University of Greifswald)H-Index: 2
#2Michael Grimm (University of Greifswald)H-Index: 7
Last.Werner Weitschies (University of Greifswald)H-Index: 41
view all 12 authors...
Abstract The instability of various small molecules, vaccines and peptides in the human stomach is a complex challenge for oral drug delivery. Recently, a novel gastro-resistant capsule – the enTRinsic™ Drug Delivery Technology capsule – has been developed. In this work, the salivary tracer technique based on caffeine has been applied to study the in vivo disintegration of enTRinsic™ capsules in 16 healthy volunteers. In addition, magnetic resonance imaging (MRI) was used to visualize GI transit...
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