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Nature Reviews Cancer
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Ombrato et al. developed a fluorescent labelling system, which uses metastatic cells themselves to directly mark neighbouring cells in vivo and revealed the lung parenchyma to be a previously unrecognized component of the metastatic niche.
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#1Evan C. Lien (MIT: Massachusetts Institute of Technology)H-Index: 1
#2M. Vander Heiden (MIT: Massachusetts Institute of Technology)H-Index: 70
Last.Mathew G.Vander Heiden (MIT: Massachusetts Institute of Technology)H-Index: 71
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The way cancer cells utilize nutrients to support their growth and proliferation is determined by cancer cell-intrinsic and cancer cell-extrinsic factors, including interactions with the environment. These interactions can define therapeutic vulnerabilities and impact the effectiveness of cancer therapy. Diet-mediated changes in whole-body metabolism and systemic nutrient availability can affect the environment that cancer cells are exposed to within tumours, and a better understanding of how di...
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#1Cynthia A. Zahnow (Johns Hopkins University)H-Index: 20
Cancer research is driven by the need for improving the lives of patients with cancer. A cancer scientist’s attention can be absorbed by the daily challenges of experimental research, running a lab and securing funding. Hearing about the patient’s experience can serve as a powerful reminder of the reason and urgency for doing this work — and the experience of being a patient can change a scientist’s approach to cancer research on a broader scale. In this Comment, the author, a cancer researcher ...
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Rivadeneira et al. show that treatment of melanoma-bearing mice with the oncolytic Vaccinia virus recruits metabolically dysfunctional CD8+ T cells, which limits tumour regression. Vaccinia-mediated engineered expression of leptin in cancer cells improved responses through metabolic reprogramming of T cells.
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#1Sydney M. Sanderson (Duke University)H-Index: 5
#2Xia Gao (Duke University)H-Index: 8
Last.Jason W. Locasale (Duke University)H-Index: 44
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Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these functions has been shown in many contexts to be relevant for cancer pathogenesis. Intriguingly, the levels of methionine obtained from the diet can have a large effect on cellular methionine metabolism. This establishes a link between nutrition and tumour...
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O’Connor et al. show that gliosis in the brain contributes to the development of central nervous system lymphomas (CNSLs) through the production of the chemokine CCL19 by astrocytes, which in turn promotes CNSL cell retention in the brain.
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Using high-resolution proteomics to analyse clinical samples from patients with advanced melanoma, Harel et al. show that the metabolic state of melanoma is associated with changes in antigen presentation-related proteins and thereby with response to immunotherapies.
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In a study published in Cell, Dong et al. employ a genome-scale CRISPR screening approach to identify both known and previously uncharacterized regulators of CD8+ T cell activity, highlighting the utility of this approach for immunotherapeutic target discovery.
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#1John H. Bushweller (UVA: University of Virginia)H-Index: 42
Mutated or dysregulated transcription factors represent a unique class of drug targets that mediate aberrant gene expression, including blockade of differentiation and cell death gene expression programmes, hallmark properties of cancers. Transcription factor activity is altered in numerous cancer types via various direct mechanisms including chromosomal translocations, gene amplification or deletion, point mutations and alteration of expression, as well as indirectly through non-coding DNA muta...
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#1Johannes G. Reiter (Stanford University)H-Index: 11
#2Marina Baretti (JHUSOM: Johns Hopkins University School of Medicine)
Last.Bert VogelsteinH-Index: 223
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Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication. Any two randomly selected cells, whether normal or cancerous, are therefore genetically different. Here, we review the different forms of genetic heterogeneity in cancer and re-analyse the extent of genetic heterogeneity within seven types of untreated epithelial cancers, with particular regard to its clinical relevance. We find that the homogeneity of predicted functional mutations in driver genes is the ...
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Cancer
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