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Naunyn-schmiedebergs Archives of Pharmacology
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Acute myeloid leukemia is an aggressive myeloid malignancy, characterized by rapid cellular proliferation and generally high mortality. Due to the lack of a complete understanding of AML, its clinical outcomes are still not satisfactory. In this study, we examined the function of the long non-coding RNA–HLA complex P5 (HCP5) on AML by analyzing the clinical samples, TCGA data, and by shRNA-mediated HCP5 deficiency in vitro. Our results showed that HCP5 is highly expressed in AML and is positive ...
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#1Tingting ZhaoH-Index: 1
#2Zhi QiuH-Index: 1
Last. Yonghua Gao (CSU: Central South University)H-Index: 1
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Ischemia-reperfusion (I/R) injury is a kind of the tissue damage caused by an abrupt re-supplying tissue with blood after a period of ischemia or hypoxia. It contributes to a wide range of pathological processes including kidney injury, circulatory arrest, and especially cardiovascular disease. However, the underlying pathological mechanism is not fully elucidated. Previously, extensive studies demonstrated that miRNAs participate in the pathogenesis of I/R injury, such as I/R-induced cardiomyoc...
1 CitationsSource
#1Rui Zhou (Yunnan University of Traditional Chinese Medicine)
#2Jinhuan GaoH-Index: 1
Last. Hongjun Yang (Yunnan University of Traditional Chinese Medicine)
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Myocardial infarction (MI) is a leading cause of mortality worldwide and it is urgent to discover effective therapies. In this study, the protective effect of salvianolic acid A (SAL) on MI induced by left anterior descending coronary artery ligation surgery and H2O2-induced H9c2 damage was evaluated. Rats were intraperitoneally injected with SAL once a day for 2 days before MI. At 24-h post-MI, the SAL-treated group showed significantly decreased infarct rate and enhanced myocardial function. M...
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#1Ayorinde Adehin (GDUT: Guangdong University of Technology)
#2Keai Sinn Tan (GDUT: Guangdong University of Technology)
Last. Wen Tan (GDUT: Guangdong University of Technology)
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Isosteviol has been reported to reverse hypertrophy and related inflammatory responses in in vitro models representative of cardiac muscle cells. The disposition of isosteviol is, however, characterized by secondary peaks and long plasma residence time despite reports of a relatively short half-life in liver fractions. The present study describes a compartmental approach to modelling the secondary peaks characteristic of isosteviol’s concentration-time data in Sprague-Dawley rats. Oral (4 mg/kg)...
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#1Rong Rong (SPU: Shenyang Pharmaceutical University)H-Index: 3
#2Rui-zhen Zhang (SPU: Shenyang Pharmaceutical University)
Last. Zhiguo Yu (SPU: Shenyang Pharmaceutical University)H-Index: 13
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R-/S-2-(2-hydroxypropanamido) benzoic acid (R-/S-HPABA), marine-derived anti-inflammatory antiplatelet drugs, were initially synthesised in our group. However, preliminary research showed that R-/S-HPABA were eliminated rapidly because of extensive hydroxylation metabolism of phenyl ring in vivo. In order to reduce significant hydroxylation metabolism to improve pharmacological activity and bioavailability, trifluoromethyl group was incorporated into R-/S-HPABA to synthesise R-/S-2-(2-hydroxypro...
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#1Rui Tong (PRC: China Medical University (PRC))H-Index: 1
#2Jingru Zhang (PRC: China Medical University (PRC))
Last. Mingxiu Ju (PRC: China Medical University (PRC))H-Index: 1
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Cervical cancer is the fourth most common female malignancy worldwide and microRNA (miR)-574-5p is a candidate oncogene in multiple cancers. The present study aimed to investigate the role and mechanism of miR-574-5p in cervical cancer. miR-574-5p inhibitors or mimics were transfected into cervical cancer cells to study the function of miR-574-5p. The effects of miR-574-5p on cell growth, invasion, and chemosensitivity were evaluated using CCK8, flow cytometry, transwell, immunofluorescence, and...
1 CitationsSource
#1Lala Qu (DICP: Dalian Institute of Chemical Physics)H-Index: 2
#2Xiuli Zhang (Soochow University (Suzhou))
Last. Xinmiao Liang (DICP: Dalian Institute of Chemical Physics)H-Index: 45
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Endothelin receptors, consisting of two subtypes, ETA and ETB, are expressed in various tissues and widely regulate cardiovascular systems. The two receptors show distinct biological characteristics and are involved in different downstream pathways. Hence, to evaluate the ETA and ETB receptors on the same platform is helpful to display their pharmacological features. In this study, we developed a label-free dynamic mass redistribution (DMR) assay to investigate the phenotypic features of the ETA...
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#1Rui-Jun Zhou (Soochow University (Taiwan))
#2Ying Zhao (Soochow University (Taiwan))
Last. Mei-Lin Xie (Soochow University (Taiwan))
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Apigenin has a protective effect on d-galactosamine (d-GalN)/lipopolysaccharide (LPS)-induced mouse liver injury through the increments of hepatic nuclear factor erythroid 2-related factor 2 (Nrf-2) and peroxisome proliferator–activated receptor γ (PPARγ) expressions, but its exact mechanisms are still uncertain. This study aimed to further verify its protective effect on hepatocytes and to determine its target of action. The results showed that after treatment of D-GalN/LPS-stimulated hepatocyt...
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#1Mengying Li (Hebei University)
#2Zishuai Wen (Hebei University)
Last. Li Chu (Hebei University)H-Index: 7
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Glycyrrhizic acid (GA) is one of the main active components in licorice and has often been reported to have cardioprotective effects. However, the underlying cellular mechanisms remain unclear. The aim of this study is to verify the protective effects of GA against isoproterenol (ISO)-induced myocardial ischemia injury in rats. Another aim is to explore the cellular mechanisms based on the L-type Ca2+ channel, myocardial cell contraction, and intracellular Ca2+ ([Ca2+]i) transient. The results s...
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) is the reason for this ongoing pandemic infection diseases termed coronavirus disease 2019 (COVID-19) that has emerged since early December 2019 in Wuhan City, Hubei Province, China. In this century, it is the worst threat to international health and the economy. After 4 months of COVID-19 outbreak, there is no certain and approved medicine against it. In this public health emergency, it makes sense to investigate the possible effects o...
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