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Anti-cancer Agents in Medicinal Chemistry
IF
2.18
Papers
1870
Papers 2028
1 page of 203 pages (2,028 results)
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#1Ruo-Jun Man (GXUN: Guangxi University for Nationalities)
#2Nasreen Jeelani (NU: Nanjing University)H-Index: 4
Last. Yu-Shun Yang (NU: Nanjing University)
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#1Marwa H. Soliman (Cairo University)
#2Mohamed A. Ragheb (Cairo University)H-Index: 2
Last. Abdel-Hady A. Abdel-Wahab (Cairo University)H-Index: 4
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#2Oana UngureanuH-Index: 1
Last. Gabriel L. Radu (Politehnica University of Bucharest)H-Index: 5
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#1Zoonish Malghani (Riphah International University)
#2Arif-ullah Khan (Riphah International University)H-Index: 21
Last. Madeeha Maqbool (Riphah International University)
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#1Agnieszka Siebert (GUT: Gdańsk University of Technology)H-Index: 3
#2Milena Deptuła (Gdańsk Medical University)H-Index: 2
Last. Janusz Rachon (GUT: Gdańsk University of Technology)H-Index: 11
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#1Saira Farman (AWKUM: Abdul Wali Khan University Mardan)
#2Aneela Javed (National University of Science and Technology)H-Index: 5
Last. Muhammad Asad (AWKUM: Abdul Wali Khan University Mardan)
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#1Iman Mansi (HU: Hashemite University)H-Index: 3
#2Mahmoud A. Al-Sha’er (Zarqa Private University)H-Index: 6
Last. Mutasem O. Taha (UJ: University of Jordan)H-Index: 23
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INTRODUCTION: Phosphoinositide-Dependent Kinase-1 (PDK1) is a serine/threonine kinase, which belongs to AGC kinase family required by cancer cells. METHODS: Pharmacophoric space of 86 PDK1 inhibitors using six diverse sets of inhibitors was explored to identify high-quality pharmacophores. The best combination of pharmacophoric models and physicochemical descriptors were selected by genetic algorithm-based QSAR analysis that can elucidate the variation of bioactivity within the training inhibito...
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#1Roghayeh Ijabi (Golestan University)
#2Parisa Roozehdar (IAU: Islamic Azad University)
Last. Amirhossein Sahebkar (MUMS: Mashhad University of Medical Sciences)H-Index: 59
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INTRODUCTION: Parallel with the progression of Chronic Lymphocytic Leukemia (CLL), the levels of 78KDa Glucose-Regulated Protein (GRP78) and Hypoxia-Inducible Factor 1 alpha (HIF-1alpha) are increased as they may activate the induction of anti-apoptotic proteins such as BCL2 Associated Athanogene 3 (BAG3). Previous studies have indicated that there is a positive correlation among GRP78, HIF-1alpha and BAG3. OBJECTIVE: To evaluate the effect of metabolic factors involved in invasive CLL on apopto...
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BACKGROUND: Current drugs used for the treatment of hormone dependent breast cancer function as anti-estrogens in the breast, in addition to Estrogen Receptor (ER) agonists in the uterus, thus elevating a woman's risk of developing uterine cancer. This is due to the lack of selective binding and partial agonistic effect of these drugs towards estrogen receptors. In recent years, therefore, researchers have turned their attention towards antiestrogens devoid of these agonist properties and thus h...
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#1Fahimeh H. Beigi (Islamic Azad University, Isfahan)
#2Soheil Fatahian (Islamic Azad University, Isfahan)H-Index: 2
Last. Amin FarzadniyaH-Index: 1
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Top fields of study
Cancer
Apoptosis
Cancer research
Biochemistry
Biology
Cancer cell
Pharmacology