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Current Problems in Pediatric and Adolescent Health Care
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Three siblings with inhalational elemental mercury toxicity presented with fever, rash, and upper respiratory tract symptoms. The patients were heavily exposed to elemental mercury that was spilled in their home and then vacuumed. Initial whole blood mercury levels were elevated at >200 µg/L, 153 µg/L and 130 µg/L (Mayo Clinic Laboratories lab reference range Clinically significant elemental mercury toxicity can resemble an infectious illness. Severe morbidity and mortality can be prevented if h...
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#1Marissa Hauptman (Harvard University)H-Index: 8
#2John R. Balmes (UCSF: University of California, San Francisco)H-Index: 59
Last. Mark D. Miller (UCSF: University of California, San Francisco)H-Index: 23
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Studies evaluating the health impacts of climate change, predict that the frequency and intensity of wildfires will increase as climate change creates longer, warmer, and drier seasons. Although respiratory morbidity in the immediate aftermath of wildfires is well documented for pediatric populations, other acute and chronic health effects from wildfires for pediatric populations are less well known. This manuscript addresses questions that arise for families, healthcare providers and school dis...
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#1Mark E. Anderson (University of Colorado Denver)H-Index: 1
#2Lauren Zajac (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Maida P. Galvez (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 18
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Families often struggle to manage their child's asthma. Clinicians caring for children with asthma struggle too as they are tasked with balancing the limited time available in clinic and the need to provide comprehensive care. As a direct consequence, critical gaps in asthma care remain with respect to asthma education and the identification and reduction of environmental asthma triggers in the home. A home visit model that augments clinic-based care is a viable way to fill gaps in understanding...
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Cases of severe childhood lead poisoning (a blood lead level (BLL) ≥45 mcg/dL) in the United States have decreased with time. Clinicians will encounter such cases only rarely. When such cases arise, however, recognizing their complexities and identifying resources that can help in management are important. We present here a case of severe childhood lead poisoning, highlighting the variable presentation, the rebound phenomenon of BLL after chelation, the usefulness of the zinc protoporphyrin as a...
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As the science on the human health effects of per-and polyfluoroalkyl substances (PFAS) emerges, there are growing concerns about the potential health impacts on children and reproductive health. PFAS exposure may affect growth, learning, and behavior of infants and older children; lower a woman's chance of getting pregnant; increase cholesterol levels; affect the immune system; and induce vaccine-reduced immune protection in children. Without existing regulation or established standards for tes...
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#1Lauren Zajac (ISMMS: Icahn School of Medicine at Mount Sinai)H-Index: 1
Last. Marissa Hauptman (Harvard University)H-Index: 8
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Laboratory testing is an important tool to assist clinicians in evaluation of patients with potential environmentally-related illness, however, it can be challenging to select or interpret the appropriate toxicological tests. Recent advances in analytical techniques and expanded consumer access to environmental laboratories led to a rise in laboratory testing for various environmental toxicants, including metals. However, most environmental tests have scant clinical evidence and are not validate...
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#1Andrew D. Gailey (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#2Aubrey E. Schachter (LSU: Louisiana State University)H-Index: 2
Last. Howard W. Mielke (Tulane University)H-Index: 32
view all 4 authors...
Numerous toxicants contaminate soil and negatively affect the environments that children explore. Accurately measuring these toxicants and characterizing the level of soil contamination may be difficult and must include measurements of both the environmental concentrations and the exposure responses of human populations. This article reviews the current methods and technologies available for quantifying soil contamination. Several intervention strategies exist for limiting human exposure to cont...
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Within a remarkably short timespan the world population doubled and transitioned from an agrarian to an urban-industrial society. The transition was accompanied by the major expansion of industries that releases enormous amounts of toxicants into the air, water, and soil. Naturally occurring and synthetic chemicals compounds utilized the same signaling system as vertebrate internal cell signaling systems. The concept of environmental signals provides insights to address the impact of biochemical...
1 CitationsSource
#1Aubrey E. Schachter (LSU: Louisiana State University)H-Index: 2
#2Andrew D. Gailey (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last. Howard W. Mielke (Tulane University)H-Index: 32
view all 4 authors...
Pollution is a concerning and highly studied area, especially in the arena of children's health. The focus of this concern, however, is typically limited to air and water pollution, leaving an important source under-studied and out of the concern of the general public. Soil pollution provides a unique threat to children's health, due to their increased exposure and susceptibility to its contaminants. The microbiome of a child is developed prior to birth and continues to evolve over their lifetim...
2 CitationsSource
#1Sara Perl Egendorf (CUNY: City University of New York)H-Index: 3
#2Andrew D. Gailey (UNC: University of North Carolina at Chapel Hill)H-Index: 2
Last. Howard W. Mielke (Tulane University)H-Index: 32
view all 4 authors...
Soil pollution is a global phenomenon, and children are uniquely susceptible to the wide range of toxicants that persist in topsoil. Given their increased exposure through mouthing activities, increased body surface area, likelihood of breathing air closer to soil, and immature immune and elimination systems, it is essential to understand the mechanisms of children's exposure and the potential health effects of toxicants found in soil. Here we describe the sources and toxicological profiles of a...
2 CitationsSource
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