Papers 2925
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#1Narges Mahmoudi (Shahed University)H-Index: 1
#2Zahra Kiasalari (Shahed University)H-Index: 11
Last. Mehrdad Roghani (Shahed University)H-Index: 25
view all 8 authors...
OBJECTIVE Prolonged diabetes mellitus causes impairments of cognition and attentional dysfunctions. Diosgenin belongs to a group of steroidal saponins with reported anti-diabetic and numerous protective properties. This research aimed to assess the effect of diosgenin on beneficially ameliorating learning and memory decline in a rat model of type 1 diabetes caused by streptozotocin (STZ) and to explore its modes of action including involvement in oxidative stress and inflammation. METHODS Rats w...
#1Alejandra Mondragón-Maya (UNAM: National Autonomous University of Mexico)H-Index: 1
Last. Ricardo Saracco-AlvarezH-Index: 3
view all 7 authors...
#1Sebastian Walther (University of Bern)H-Index: 28
#2Manuel Morrens (University of Antwerp)H-Index: 18
#1Katharina M. Kubera (Heidelberg University)H-Index: 10
#2Nadine D. Wolf (Heidelberg University)H-Index: 14
Last. Robert Christian Wolf (Heidelberg University)H-Index: 31
view all 10 authors...
#1Nina Dalkner (University of Graz)H-Index: 6
#2Susanne Bengesser (University of Graz)H-Index: 9
Last. Rene Pilz (University of Graz)H-Index: 5
view all 16 authors...
#2Elisabeth Hertenstein (University of Bern)
Last. Christoph NissenH-Index: 33
view all 10 authors...
: Arousal and sleep represent fundamental physiological domains, and alterations in the form of insomnia (difficulty falling or staying asleep) or hypersomnia (increased propensity for falling asleep or increased sleep duration) are prevalent clinical problems. Current first-line treatments include psychotherapy and pharmacotherapy. Despite significant success, a number of patients do not benefit sufficiently. Progress is limited by an incomplete understanding of the -neurobiology of insomnia an...
#1Violette Coppens (University of Antwerp)H-Index: 10
#2Oskar De Wachter (University of Antwerp)
Last. Manuel Morrens (University of Antwerp)H-Index: 18
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INTRODUCTION: Current diagnoses in psychiatry are solely based on the evaluation of clinical presentation by the treating psychiatrist. This results in a high percentage of misdiagnosis and consequential inefficient treatment; especially regarding major depressive disorder (MDD), depression in the context of bipolar disorder (BD-D), bipolar disorder with manic symptoms (BD-M), and psychosis in the context of schizophrenia (SZ). Objective biomarkers allowing for accurate discriminatory diagnostic...
#1Anna Stippl (Charité)
#2Fatma Nur Kirkgöze (Charité)
Last. Simone Grimm (Charité)H-Index: 24
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BACKGROUND/AIMS/METHODS: Electroconvulsive therapy (ECT) is still one of the most potent treatments in the acute phase of major depressive disorder (MDD) and particularly applied in patients considered treatment resistant. However, despite the frequent and widespread use of ECT for >70 years, the exact neurobiological mechanisms underlying its efficacy remain unclear. The present review aims to describe differential antidepressant and cognitive effects of ECT as well as effects on markers of neu...
#1Demet Gurler (UAB: University of Alabama at Birmingham)H-Index: 4
#2David M. White (UAB: University of Alabama at Birmingham)H-Index: 24
Last. Adrienne C. Lahti (UAB: University of Alabama at Birmingham)H-Index: 41
view all 7 authors...
There is no pharmacological treatment to remediate cognitive impairment in schizophrenia (SZ). It is imperative to characterize underlying pathologies of memory processing in order to effectively develop new treatments. In this longitudinal study, we combined functional magnetic resonance imaging during a memory encoding task with proton MR spectroscopy to measure hippocampal glutamate + glutamine (Glx). Seventeen SZ were scanned while unmedicated and after 6 weeks of treatment with risperidone ...
#1Parastoo Akbari (Semnan University)H-Index: 1
#2Mahmoud Najafi (Semnan University)H-Index: 5
Last. Hossein Miladi-Gorji (Semnan University)H-Index: 10
view all 4 authors...
OBJECTIVE: This study was designed to examine whether enriched environments (EE) would attenuate object recognition and spatial learning and memory deficits and locomotor sensitization induced by methadone maintenance treatment (MMT) in morphine-withdrawn rats. METHODS: Male Wistar rats (170 +/- 10 g) were injected with bi-daily doses (10 mg/kg, 12-h intervals) of morphine for 14 days. Rats receiving MMT were reared in the standard environment (SE) or EE during 30 days of morphine withdrawal. Th...
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