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Radiotherapy and Oncology
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31988
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#1D. Winkel (UU: Utrecht University)H-Index: 5
#2Gijsbert H. Bol (UU: Utrecht University)H-Index: 14
Last. Bas W Raaymakers (UU: Utrecht University)H-Index: 32
view all 12 authors...
Abstract Background and purpose Patients were treated at our institute for single and multiple lymph node oligometastases on the 1.5T MR-linac since August 2018. The superior soft-tissue contrast and additional software features of the MR-linac compared to CBCT-linacs allow for online adaptive treatment planning. The purpose of this study was to perform a target coverage and dose criteria based evaluation of the clinically delivered online adaptive radiotherapy treatment compared with convention...
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#1M. KwintH-Index: 6
#2Iris WalravenH-Index: 4
Last. T. JanssenH-Index: 6
view all 6 authors...
Abstract Introduction The aim of this work is to assess the validity of real world data (RWD) derived from an electronic toxicity registration (ETR). As a showcase, the NTCP-models of acute esophageal toxicity (AET) for concurrent chemoradiation (CCRT) for NSCLC patients were used to validate the ETR of AET before/after dose de-escalation to the mediastinal lymph nodes. Material and methods One hundred and one patients received 24 × 2.75 Gy and 116 patients received de-escalated dose of 24 × 2.4...
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#1K MittauerH-Index: 6
#2P.M. HillH-Index: 4
Last. John E. BayouthH-Index: 21
view all 4 authors...
Abstract Background and purpose To investigate deformable image registration (DIR) and multi-fractional dose accumulation accuracy of a clinical MR-guided online adaptive radiotherapy (MRgoART) program, utilizing clinically-based magnitudes of abdominal deformation vector fields (DVFs). Materials and methods A heterogeneous anthropomorphic multi-modality abdominal deformable phantom was comprised of MR and CT anatomically-relevant materials. Thermoluminescent dosimeters (TLDs) were affixed withi...
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#1Cai Xu (University of Texas MD Anderson Cancer Center)H-Index: 7
#2JianYue Jin (Case Western Reserve University)H-Index: 8
Last. Steven Hsesheng Lin (University of Texas MD Anderson Cancer Center)H-Index: 26
view all 8 authors...
Abstract Purpose To test the hypothesis that effective dose to circulating immune cells (EDIC) impacts the severity of radiation-induced lymphopenia and clinical outcomes of esophageal cancer patients treated with concurrent chemoradiotherapy (CCRT). Material and methods 488 esophageal cancer patients treated with CCRT with and without surgery were analyzed. The EDIC model considers the exposure of circulating immune cells as the proportion of blood flow to lung, heart, liver, and the volume of ...
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#1Qiang Cao (SEU: Southeast University)
#2Yimin Li (Ha Tai: Xiamen University)
Last. Qin Lin (Ha Tai: Xiamen University)
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Abstract Background and purpose To investigate potential image markers for early prediction of treatment response on thoracic esophagus squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CCRT). Materials and methods 159 thoracic ESCC patients enrolled from two institutions were divided into training and validation sets. A total of 944 radiomics features were extracted from pretreatment 18F-FDG PET images. We first performed the inter-observer reproducibility test in 10 pai...
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#1Jessica Chan (U of O: University of Ottawa)
#2Jeppe FriborgH-Index: 10
Last. C. Norman ColemanH-Index: 26
view all 16 authors...
Abstract Background A high cancer burden exists among indigenous populations worldwide. Canada and Greenland have similar geographic features that make health service delivery challenging. We sought to describe geographic access to radiotherapy for indigenous populations in both regions. Methods We used geospatial analyses to calculate distance and travel-time from indigenous communities in Canada and Greenland to the nearest radiotherapy center. We calculated the proportion of indigenous commun...
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Abstract Purpose/objective(s) To report tumor genomic factors associated with overall survival (OS) and local failure (LF) for patients with colorectal cancer (CRC) who received metastasis-directed stereotactic body radiation therapy (SBRT). Materials/methods This was a retrospective review of patients with CRC who received metastasis-directed SBRT. Tumor genomic alterations were identified through KRAS, BRAF, or a 50-gene next generation sequencing panel. OS and LF were estimated using Kaplan-M...
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#1Holger Göbel (University of Split)
#2Maike Büttner-Herold (FAU: University of Erlangen-Nuremberg)H-Index: 19
Last. Luitpold Distel (FAU: University of Erlangen-Nuremberg)H-Index: 24
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Abstract Background and purpose Tumour infiltrating lymphocytes (TIL) and tumour associated macrophages (TAM) play a key role in anticancer immunosurveillance. We studied their influence on response to neoadjuvant radiochemotherapy (RCT) and prognosis in patients with oesophageal adenocarcinoma (OAC). Materials and methods Between 10/2004 and 06/2018, pre-RCT biopsy-specimens were available from 76 patients with locally advanced, non-metastatic OAC scheduled for trimodality therapy. We evaluated...
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#1Yakun Zhang (UMB: University of Maryland, Baltimore)H-Index: 6
#2Panos Zanos (UMB: University of Maryland, Baltimore)H-Index: 15
Last. Zeljko Vujaskovic (UMB: University of Maryland, Baltimore)H-Index: 52
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Abstract Background and purpose Patients with life-threatening illnesses, such as cancer, experience emotional distress. This study was to investigate the molecular and cellular mechanisms of relevant psychological stressor on tumor growth and therapeutic resistance. Materials and Methods Stress was induced in C57BL/6J mice bearing LLC lung tumors by exposure to a conspecific mice receiving inescapable foot shocks. Mice were irradiated at 7 Gy for 3 consecutive days. Behaviors were monitored by ...
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#1T. ZhaiH-Index: 2
Last. Sjoukje F. OostingH-Index: 20
view all 13 authors...
Abstract Background and purpose To develop and validate a pre-treatment radiomics-based prediction model to identify pathological lymph nodes (pLNs) at risk of failures after definitive radiotherapy in head and neck squamous cell carcinoma patients. Materials and methods Training and validation cohorts consisted of 165 patients with 558 pLNs and 112 patients with 467 pLNs, respectively. All patients were primarily treated with definitive radiotherapy, with or without systemic treatment. The endp...
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