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Molecular and Biochemical Parasitology
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6216
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#1Santoshi Nayak (IIT-KGP: Indian Institute of Technology Kharagpur)H-Index: 3
#2Sudip K. Ghosh (IIT-KGP: Indian Institute of Technology Kharagpur)H-Index: 39
Abstract Chitin, a homopolymer of β-(1,4) linked N-acetylglucosamine (GlcNAc), is a major component of cyst wall in the protozoan parasites Entamoeba histolytica (Eh) and Entamoeba invadens (Ei). The Entamoeba chitin synthase makes chitin at the vesicular membrane rather than the plasma membrane in fungi, even though the chemistry of chitin synthesis is most likely the same. However, the role of nucleotide sugar transporter(s) (NSTs) that are involved in chitin synthesis in Entamoeba are not yet...
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#1Heather A. Walters (Clemson University)
#2Brenda H. Welter (Clemson University)H-Index: 13
Last.Lesly A. Temesvari (Clemson University)H-Index: 15
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Abstract Entamoeba histolytica is an intestinal parasite infecting over 50 million people worldwide and is the causative agent of amebic dysentery and amoebic liver abscess. In the human host, E. histolytica experiences stress brought on by nutrient deprivation and the host immune response. To be a successful parasite, E. histolytica must counter the stress; therefore, understanding the stress response may uncover new drug targets. In many systems, the stress response includes down-regulation of...
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#1Mark C. Jenkins (ARS: Agricultural Research Service)H-Index: 42
#2Celia O'Brien (ARS: Agricultural Research Service)H-Index: 8
Last.Carolyn Parker (ARS: Agricultural Research Service)H-Index: 5
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Abstract Release of sporozoites from Eimeria oocysts/sporocysts is an essential step in the intracellular development of the parasite in its host. Little is known about this process except that elevated temperature (∼ 40 °C) plus trypsin and bile salts are required for sporozoite to escape from sporocysts. In this study, it was found that adding a reducing agent, either dithiothreitol (DTT) or Tris(2-carboxyethyl)phosphine hydrochloride (TCEP), increased the lifespan of sporozoites released from...
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#1Eugene A. Rogozhin (RAS: Russian Academy of Sciences)H-Index: 15
#2Mikhail M. Solovyev (Tomsk State University)H-Index: 8
Last.G. I. Izvekova (RAS: Russian Academy of Sciences)H-Index: 6
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Abstract The inhibitors produced by the parasitic worms successfully protect them from the host’s proteases and are supposed to underlie the host-parasite specificity. Our previous study has shown that the extracts from the pike tapeworm Triaenophorus nodulosus inhibit host proteinases and commercial trypsin. We aimed to isolate and identify the components responsible for trypsin inactivation. After a two-step separation the molecular masses were measured by SE-HPLC. The sample proved to contain...
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Schistosomes are parasitic blood flukes that infect approximately 250 million people worldwide. The disease known as schistosomiasis, is the second most significant tropical parasitic disease after malaria. Praziquantel is the only effective drug currently licensed for schistosomiasis and there are concerns about resistance to the drug. There has been much effort to develop vaccines against schistosomiasis to produce long-term protection in endemic regions. Surface-associated proteins, and in pa...
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#1Harvinder Kour Khera (CSIR: Council of Scientific and Industrial Research)H-Index: 2
#2Susheel Kumar Singh (CSIR: Council of Scientific and Industrial Research)H-Index: 1
Last.Subhash Chandra Singh (CSIR: Council of Scientific and Industrial Research)H-Index: 1
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Abstract Chorismate synthase (Cs) is the last enzyme of the main trunk of shikimate pathway and catalyzes formation of chorismate, a major aromatic metabolite precursor. We have previously reported that Cs is highly conserved across different Plasmodium sp. Here we report that Cs from malaria parasites are bifunctional enzymes through expression and functional studies of two recombinant proteins rPfCs (Cs from P. falciparum) and rPvCs (Cs from P. vivax). We confirm bifunctional activity of both ...
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#1Ying Zhang (WHU: Wuhan University)H-Index: 3
#2Li He (WHU: Wuhan University)H-Index: 5
Last.Guo-Bin Cai (WHU: Wuhan University)H-Index: 9
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Abstract The CaaX proteases are closely related in the post-translational modification of many membrane-bound or secreted proteins and play a key role in the activation or stabilization of these molecules belonging to the CAAX family. In this study, a full-length cDNA putatively encoding a FACE-1/Ste24p CaaX protease (type I) of the Schistosoma japonicum was isolated. The cDNA, named SjSte24p, composed of 1646 bp and encoded 473 amino acids with predicted Mr/pI as 54.77 kDa/8.04. SjSte24p is a m...
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#1Fuli Zheng (Fujian Medical University)
#2Claudia Colasante (University of Giessen)H-Index: 8
Last.Frank Voncken (University of Hull)H-Index: 21
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Abstract Similar to higher eukaryotes, the protist parasite T. brucei harbours several iron-containing proteins that regulate DNA and protein processing, oxidative stress defence and mitochondrial respiration. The synthesis of these proteins occurs either in the cytoplasm or within the mitochondrion. For mitochondrial iron cluster protein synthesis, iron needs to be transported across the solute impermeable mitochondrial membrane. In T. brucei we previously identified 24 mitochondrial carrier pr...
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#1Wenjie Wu (University of Texas at Austin)H-Index: 13
#2Philip T. LoVerde (University of Texas at Austin)H-Index: 32
Abstract Nuclear receptors (NRs) belong to a large protein superfamily which includes intracellular receptors for secreted hydrophobic signal molecules, such as steroid hormones and thyroid hormones. They regulate development and reproduction in metazoans by binding to the promoter region of their target gene to activate or repress mRNA synthesis. Isolation and characterization of NRs in the parasitic trematode Schistosoma mansoni identified two homologues of mammalian thyroid receptor (TR). Thi...
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#1Alba Cortés (University of Cambridge)H-Index: 1
#2Laura E. Peachey (University of Cambridge)H-Index: 7
Last.Cinzia Cantacessi (University of Cambridge)H-Index: 32
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Abstract The gastrointestinal (GI) tract of vertebrates is inhabited by a vast array of organisms, i.e., the microbiota and macrobiota. The former is composed largely of commensal microorganisms, which play vital roles in host nutrition and maintenance of energy balance, in addition to supporting the development and function of the vertebrate immune system. By contrast, the macrobiota includes parasitic helminths, which are mostly considered detrimental to host health via a range of pathogenic e...
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