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Progress in Neuro-psychopharmacology & Biological Psychiatry
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#1Shui Tian (SEU: Southeast University)H-Index: 2
#2Siqi Zhang (SEU: Southeast University)H-Index: 2
Last.Zhijian Yao (Nanjing Medical University)H-Index: 9
view all 12 authors...
Abstract Background The fundamental pathophysiology of major depressive disorder (MDD) could be characterized by functional brain networks which tightly and dynamically connect into groups as communities, making the flexible brain possible to external multifarious demands. We aim to scrutinize what brain dynamics go awry in MDD and antidepressants effects on multi-dimensional symptoms. Methods Thirty-five patients and thirty-five controls underwent resting-state functional magnetic resonance ima...
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#1Rachel Rosengard (McGill University)H-Index: 1
#2Carolina Makowski (McGill University)H-Index: 6
Last.Martin Lepage (McGill University)H-Index: 41
view all 7 authors...
Abstract Individuals with sub-threshold psychotic symptoms (STPS) are considered at clinical high risk for psychosis (CHR). Imaging studies comparing CHR and patients shortly after a first episode of psychosis (FEP) support progressive cortical thinning by illness stage. However, at least 30% of FEP patients deny pre-onset STPS, suggesting no history of CHR. This calls into question the generalizability of previous imaging findings. To better understand the physiology of early psychosis symptomo...
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#1Lei Sun (Alkermes)H-Index: 2
#2Sergey Yagoda (Alkermes)
Last.Borje Darpo (UR: University of Rochester)H-Index: 20
view all 9 authors...
Abstract Background OLZ/SAM is a combination of olanzapine, an atypical antipsychotic, and samidorphan, an opioid antagonist, and is in development for the treatment of schizophrenia and bipolar disorder. OLZ/SAM is under development with the intent to provide the established antipsychotic efficacy of olanzapine while mitigating olanzapine-associated weight gain. This thorough QT study assessed the effects of therapeutic and supratherapeutic doses of OLZ/SAM on cardiac repolarization in patients...
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#1Yansong Li (NU: Nanjing University)H-Index: 1
#2Nicolas Ramoz (French Institute of Health and Medical Research)H-Index: 27
Last.Jean-Claude Dreher (CNRS: Centre national de la recherche scientifique)H-Index: 26
view all 4 authors...
Abstract The endocrine system plays an essential role in communication between various organs of the body to maintain homeostasis. Both substance use disorders (SUDs) and non-substance abuse disrupt this system and lead to hormonal dysregulations. Here, we focus on the comparison between the function of the endocrine system in gambling disorders and alcohol addiction to understand the commonalities and differences in their neurobiological and psychological underpinnings. We review human research...
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#1Talise E. Müller (UFSM: Universidade Federal de Santa Maria)H-Index: 5
#2Barbara D. Fontana (University of Portsmouth)H-Index: 2
Last.Denis Broock Rosemberg (UFSM: Universidade Federal de Santa Maria)H-Index: 26
view all 10 authors...
Abstract Drug abuse and brain disorders related to drug comsumption are public health problems with harmful individual and social consequences. The identification of therapeutic targets and precise pharmacological treatments to these neuropsychiatric conditions associated with drug abuse are urgently needed. Understanding the link between neurobiological mechanisms and behavior is a key aspect of elucidating drug abuse-related targets. Due to various molecular, biochemical, pharmacological, and ...
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#1L. Duart-Castells (University of Barcelona)H-Index: 3
#2M. Carmen Blanco-Gandía (University of Barcelona)
Last.Marta Rodríguez-Arias (University of Valencia)H-Index: 26
view all 8 authors...
Abstract 3,4-Methylenedioxypyrovalerone (MDPV) is a new psychoactive substance (NPS) considered to be a cocaine-like psychostimulant. The substitution of an established illicit drug as cocaine with an NPS is a pattern of use reported among drug users. The aim of this study was to investigate the relationship between cocaine and MDPV in the reinstatement of the conditioned place preference (CPP) paradigm, in order to establish whether there is cross-reinstatement between the two psychostimulants....
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#1Jacques Epelbaum (Paris V: Paris Descartes University)H-Index: 7
#2Jérémy Terrien (CNRS: Centre national de la recherche scientifique)H-Index: 15
Abstract The neuroendocrine system (NES) plays a crucial role in synchronizing the physiology and behavior of the whole organism in response to environmental constraints. The NES consists of a hypothalamic-pituitary-target organ axis that acts in coordination to regulate growth, reproduction, stress and basal metabolism. The growth (or somatotropic), hypothalamic-pituitary-gonadal (HPG), hypothalamic-pituitary-adrenal (HPA) and hypothalamic-pituitary-thyroid (HPT) axes are therefore finely tuned...
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#1Sarah Beggiato (University of Chieti-Pescara)
#2Alessandro Ieraci (University of Milan)H-Index: 12
Last.Luca Ferraro (University of Ferrara)H-Index: 41
view all 5 authors...
Abstract Cannabis remains one of the most widely used illicit drugs during pregnancy. The main psychoactive component of marijuana (Δ9-tetrahydrocannabinol, THC) is correlated with untoward physiological effects in the offspring. Neurobehavioral and cognitive impairments have been reported in longitudinal studies on children and adolescents prenatally exposed to marijuana, and a link to psychiatric disorders has been proposed. Interestingly, the deleterious effects of prenatal cannabis use are s...
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#1Victoria S. Marshe (U of T: University of Toronto)H-Index: 8
#2Farhana Islam (U of T: University of Toronto)
Last.Daniel MüllerH-Index: 93
view all 16 authors...
Abstract Background MicroRNAs (miRNAs) are small 22 nucleotides long, non-coding RNAs that are potential biomarkers for antidepressant treatment response. We aimed to replicate previous associations of miRNAs with antidepressant treatment response in a sample of older adults diagnosed with late-life depression. Methods Our sample included 184 older adults diagnosed with moderately severe depression that received open-label venlafaxine (up to 300 mg/day) for approximately 12 weeks. We quantified ...
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