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Zeitschrift Fur Rheumatologie
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5107
Papers 5325
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A case with rheumatoid arthritis and insufficient compensation under disease-modifying combined long-term therapy with methotrexate and leflunomide is reported. After recovery from a COVID-19 infection, a tumor necrosis factor (TNF) inhibitor therapy was initiated. Until now no reactivation of the COVID-19 infection with positive SARS-CoV‑2 antibody status has occurred.
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#1H. J. Kim (Kosin University)
#2Kwang-Hyuk Kim (Kosin University)H-Index: 3
Last. Yang Kim (Kosin University)H-Index: 13
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Behcet's disease (BD) is a recurrent, multisystemic, inflammatory blood vessel disorder that can result in mouth, genital, and skin ulcers; arthritis; and eye and intestinal inflammation. We describe a 21-year-old Korean female patient with intestinal BD refractory to conventional medical treatment and biologic drugs. The patient was initially treated with high-dose steroids and sulfasalazine. Two months later, a skin rash occurred as a side effect of sulfasalazine. Therefore, infliximab (IFX) w...
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#1E. Csernok (University of Tübingen)H-Index: 1
#2Bernhard Hellmich (University of Tübingen)H-Index: 35
The cornerstone of the laboratory diagnostics of small vessel vasculitis is the detection of antineutrophil cytoplasmic antibodies (ANCA). The current international consensus recommendations suggest that proteinase 3 (PR3) and myeloperoxidase (MPO) ANCA immunoassays should be used as a first-line test if there is a justified suspicion of ANCA-associated vasculitis (AAV). A second method is only recommendable when the immunoassay shows a negative or borderline result. The precise identification o...
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#1S.-M. Yuan (Fujian Medical University)H-Index: 2
Patients with immunoglobulin G4-related thoracic aortitis often have nonspecific symptoms, but pain in the chest or back is common. The rate of misdiagnosis of immunoglobulin G4-related thoracic aortitis is high, which may lead to mistreatment in extreme cases. A correct diagnosis should be based on comprehensive medical imaging, pathology, and laboratory and immunohistochemical results. Most patients’ condition can be significantly improved using conservative or surgical treatment.
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#1T. Thiele (Hochschule Hannover)
#2T. Seeliger (Hochschule Hannover)
Last. D. Ernst (Hochschule Hannover)
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A 64-year-old male patient developed over a period of 20 years a peripheral neuropathy symmetrically affecting the upper and lower limbs. The histological examination of a sural nerve biopsy revealed a severe axonal neuropathy. Despite extensive laboratory investigations including immunological and metabolic tests the origin could not be identified. Finally, a Schirmer test revealed xerophthalmia. A subsequent salivary gland biopsy from the lower lip revealed a grade III lymphocytic inflammation...
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#1Martin Krusche (Charité)H-Index: 1
Last. Johannes Knitza (FAU: University of Erlangen-Nuremberg)H-Index: 1
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Mit der steigenden Verwendung von Smartphones einhergehend, nimmt auch die Nutzung von mobilen Applikationen (Apps) rapide zu. Im medizinischen Kontext konnten chronisch kranke Patienten von dem Einsatz dauerhaft profitieren. Verstarkt wird diese Entwicklung durch das Digitale-Versorgung-Gesetz (DVG), wonach Patienten ab Q4/2020 einen Rechtsanspruch auf bestimmte Apps, sog. digitale Gesundheitsanwendungen (DiGAs), haben, die von den gesetzlichen Krankenkassen erstattet werden. Besonders im Berei...
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#1Anna KernderH-Index: 2
#2Johanna MuckeH-Index: 2
Last. Matthias SchneiderH-Index: 35
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Rheumatologists are often confronted by patients with muscle weakness and elevated creatine kinase (CK) levels. Myositis cannot always be determined to be the cause of the complaints. This article presents two cases from this hospital where the diagnosis could be only be determined by muscle biopsy. In the first case the patient presented with muscle weakness, pathological weight loss and a significant increase in CK levels. A muscle biopsy revealed an immune-mediated necrotizing myopathy (IMNM)...
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Testing for antinuclear antibodies (ANA) on human epithelial cell lines (HEp-2) using indirect immunofluorescence (IIF) is central for ruling out or for diagnosing connective tissue diseases and other diseases, such as primary biliary cholangitis and autoimmune hepatitis as well as drug-induced ANA. The comprehensive description of 29 different ANA-IIF patterns by the international consensus of ANA patterns (ICAP) facilitates the harmonization of ANA-IIF diagnostics. Positive ANA tests are frequ...
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