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Seminars in Arthritis and Rheumatism
IF
5.07
Papers
2763
Papers 2761
1 page of 277 pages (2,761 results)
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#1Michael Hughes (MAHSC: Manchester Academic Health Science Centre)H-Index: 62
#2Richard Hodgson (University of Manchester)H-Index: 21
Last.Ariane L. Herrick (MAHSC: Manchester Academic Health Science Centre)H-Index: 52
view all 9 authors...
Introduction Objective outcome measures are needed to facilitate clinical trials of much needed treatments for calcinosis in systemic sclerosis (SSc). Our primary aim was to compare radiography, computed tomography (CT) and magnetic resonance imaging (MRI) to measure calcinotic lesions. Secondary objectives included to examine reproducibility of radiography and MRI, and inter-rater reliability of MRI. Materials and Methods 15 patients with SSc and clinically apparent calcinosis were studied. On ...
#1Jianghong Deng (Capital Medical University)
#2Nathalie E. Chalhoub (University of Cincinnati Academic Health Center)
Last.Hermine I. Brunner (Cincinnati Children's Hospital Medical Center)H-Index: 44
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Abstract Glucocorticoids are potent anti-inflammatory and immunosuppressant medications and remain the mainstay of systemic lupus erythematosus (SLE) therapy. The potency of a specific glucocorticoid, i.e., the dose of glucocorticoid that is required to produce a specific effect, is dependent on its pharmacokinetic (PK) and pharmacodynamic (PD) properties. In this review, we summarize the PK/PD properties of commonly used glucocorticoids in an attempt to better delineate their role in the manage...
#1P. M. Maloley (UNMC: University of Nebraska Medical Center)H-Index: 1
#2Bryant R. England (UNMC: University of Nebraska Medical Center)H-Index: 7
Last.Ted R MikulsH-Index: 44
view all 13 authors...
Abstract Objective Although post-traumatic stress disorder (PTSD) is identified as a risk factor in the development of rheumatoid arthritis (RA), associations of PTSD with disease progression are less clear. To explore whether PTSD might influence disease-related measures of systemic inflammation in RA, we compared serum cytokine/chemokine (cytokine) concentrations in RA patients with and without PTSD. Methods Participants were U.S. Veterans with RA and were categorized as having PTSD, other for...
Abstract Introduction In previous studies we showed that prevalence of myocardial fibrosis as assessed by late enhancement on cardiac MRI in SSc patients is 45% and is associated to diffuse disease (dcSSc) and lower left ventricle ejection fraction; microvascular damage defined as decreased perfusion on cardiac MRI after adenosine infusion, was also very frequent (79%). Our aim was to identify baseline characteristics associated to the development of cardiovascular outcomes (heart failure, coron...
#1Mickaël Hiligsmann (PHRI: Public Health Research Institute)H-Index: 28
#2S.A. WilliamsH-Index: 2
Last.Jean-Yves Reginster (KSU: King Saud University)H-Index: 92
view all 6 authors...
Abstract Objectives There is emerging evidence supporting sequential therapy with an osteoanabolic followed by an antiresorptive in patients at high-risk of fragility fractures. This study assessed the cost-effectiveness of sequential treatment with abaloparatide (ABL) followed by alendronate (ALN) [(ABL/ALN)] compared with teriparatide (TPTD) followed by ALN (TPTD/ALN). Methods A previously validated Markov microsimulation model was adapted to estimate the cost-effectiveness of sequential ABL/A...
#1Manuel Bécède (Medical University of Vienna)H-Index: 2
#2F. Alasti (Medical University of Vienna)H-Index: 11
Last.Daniel Aletaha (Medical University of Vienna)H-Index: 62
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Abstract Background Despite modern therapeutics and treatment strategies, a subset of rheumatoid arthritis (RA) patients remains insufficiently responsive to multiple therapies. Here, we identify predictors of such refractory RA (“reRA”). Methods Patients from a longitudinal academic clinical database with reRA (defined as failing to reach the treatment target of at least low disease activity with ≥3 DMARD courses, including ≥1 biological, over a total of ≥18 months) were compared to patients wh...
#1Andrew Kwan (Queen's University)H-Index: 2
#2Sherief Marzouk (U of T: University of Toronto)H-Index: 1
Last.Zahi Touma (Toronto Western Hospital)H-Index: 20
view all 9 authors...
Abstract Objectives This study aimed to: 1) determine the prevalence of depression and anxiety in SLE patients using the Center for Epidemiological Studies-Depression Scale [CES-D], Hospital Anxiety and Depression Scale [HADS], and Beck Anxiety Inventory [BAI] questionnaires; 2) study the criterion validity, interpretability, and test-retest reliability of CES-D, HADS and BAI; and 3) evaluate their diagnostic accuracy when compared to the assessment of an independent psychiatric assessment using...
#1Gloria María Pontes-Quero (CSIC: Spanish National Research Council)H-Index: 1
#2Luis García-Fernández (CSIC: Spanish National Research Council)H-Index: 19
Last.Blanca Vázquez-Lasa (CSIC: Spanish National Research Council)H-Index: 5
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Abstract Objective Osteoarthritis is a chronic, painful and disabling disease which prevalence is increasing in developing countries. Patients with osteoarthritis present a reduced synovial fluid viscoelasticity due to a reduction in concentration and molecular weight of hyaluronic acid. Currently, the main treatment used to restore the compromised rheological properties of synovial fluid is the viscosupplementation by hyaluronic acid injections that can be combined with oral anti-inflammatory d...
#1Johanna Sigaux (French Institute of Health and Medical Research)H-Index: 3
#2Luca Semerano (French Institute of Health and Medical Research)H-Index: 20
Last.Nathalie Saidenberg-Kermanac’h (French Institute of Health and Medical Research)H-Index: 12
view all 8 authors...
Abstract Introduction Chronic back pain (CBP) is a frequent complaint in patients with sarcoidosis, which challenges the clinician as multiples causes may potentially underlie this symptom. Interestingly, some reports suggest that the coexistence of sarcoidosis and spondyloarthritis (SpA) may be frequent. This study aimed to determine the prevalence of axial radiographic and non-radiographic SpA in patients with sarcoidosis and CBP and assess the association between patient characteristics and S...
#1Jaume Alijotas-Reig (Hebron University)H-Index: 17
Last.Josep Mª Gris (Autonomous University of Barcelona)
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Abstract Background No absolute data on the treatment of antiphospholipid antibodies (aPL) related to refractory obstetric complications exist to date. TNF-α play a major role in this disorder. Objective To assess the effectiveness of TNF-α blockers in 18 aPL-positive women with recurrent infertility after therapy with low-molecular-weight heparin (LMWH) plus aspirin (LDA) plus hydroxychloroquine (HCQ). Methods Prospective case-series of 12 women fulfilling Sydney criteria for obstetric antiphos...
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