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Reproductive Biology and Endocrinology
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2.59
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1788
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#1Genia F. Burchall (RMIT: RMIT University)H-Index: 2
#2Dodie S. Pouniotis (RMIT: RMIT University)H-Index: 17
Last.Terrence J. Piva (RMIT: RMIT University)H-Index: 17
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Background The fibrinolytic system and its inhibitors play a number of roles, apart from their function in blood haemostasis and thrombosis, namely in ovarian folliculogenesis and in ovulation. Plasminogen is converted to active plasmin at the time of follicular rupture through a decrease in plasminogen activator inhibitor-1 (PAI-1) and an increase in plasminogen activators. Oligo−/anovulation and follicle arrest are key characteristics of PCOS, but studies evaluating fibrinolytic/proteolytic ma...
#1Mauro Cozzolino (Yale University)
Last.Giovanni Sisti (Lincoln Hospital)H-Index: 7
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Many infertility specialists support the existence of a relationship between the levels of mitochondrial DNA and the quality of the blastocysts. Despite the extensive use of pre-implantation genetic testing for aneuploidy, a significant percentage of euploid embryos do not implant even though the endometrium is normal. Mitochondrial DNA may be used as a new test in evaluating embryonic vitality.
#1Jing Zhao (CSU: Central South University)H-Index: 5
#2Yi Yan (CSU: Central South University)H-Index: 2
Last.Yanping Li (CSU: Central South University)H-Index: 2
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Objective To assess the predictive value of each individual morphological parameter: blastocoele expansion degree, inner cell mass (ICM), and trophectoderm (TE) grades on the clinical pregnancy outcome in frozen–warmed embryo transfer (FET) cycles.
Background Women with Polycystic Ovary Syndrome (PCOS) present a heterogeneous reproductive and metabolic profile with an increased lifetime risk of Type 2 Diabetes (T2D). Early biomarkers of these metabolic disturbances in PCOS women have not been identified. The abundance of circulating insulin gene promotor cell-free DNA (INS cfDNA) was shown to be valuable as a predictive biomarker of β-cell death in individuals with Type 1 diabetes (T1D) as well as with gestational diabetes. Since β-cell de...
#1Valentina Pampanini (KI: Karolinska Institutet)H-Index: 2
#2Kirsi Jahnukainen (KI: Karolinska Institutet)H-Index: 28
Last.Olle Söder (KI: Karolinska Institutet)H-Index: 37
view all 7 authors...
Background A low oxygen supply to the fetus causes intrauterine growth restriction and can affect gonadal development of the offspring, having a potential impact on fertility. We investigated histology and gene expression in the postnatal rat ovary after fetal hypoxia induced by uterine artery ligation.
#1Jun TanH-Index: 1
#2Yang ZouH-Index: 1
Last.Qiong-Fang WuH-Index: 1
view all 9 authors...
Background Although in vitro culture system has been optimized in the past few decades, the problem of few or no high quality embryos has been still not completely solved. Accordingly, fully understanding the regulatory mechanism of pre-implantation embryonic development would be beneficial to further optimize the in vitro embryo culture system. Recent studies have found the expression of c-kit in mouse embryo and its promotion effects on mouse embryonic development. However, it is unclear the e...
#1Jacob Farhi (TAU: Tel Aviv University)H-Index: 16
#2Kfir Cohen (TAU: Tel Aviv University)
Last.Raoul Orvieto (TAU: Tel Aviv University)H-Index: 33
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Backgroud In order to maximize In vitro fertilization (IVF) success rates in advanced- age patients, it has been suggested to favor the use of intracytoplasmic sperm injection (ICSI) over conventional insemination (CI), with the notion that ICSI would serve as a tool to overcome interference in sperm oocyte interaction and sperm oocyte penetration issues that can be related to maternal age and are not due to sperm abnormalities. We therefore aim to evaluate the role of ICSI in the treatment of n...
#1Andrea Di Nisio (UNIPD: University of Padua)H-Index: 7
#2Carlo Foresta (UNIPD: University of Padua)H-Index: 53
Over the past two decades, public health has focused on the identification of environmental chemical factors that are able to adversely affect hormonal function, known as endocrine disruptors (EDs). EDs mimic naturally occurring hormones like estrogens and androgens which can in turn interfere with the endocrine system. As a consequence, EDs affect human reproduction as well as post and pre-natal development. In fact, infants can be affected already at prenatal level due to maternal exposure to ...
#1Longfei Xiao (GAU: Gansu Agricultural University)H-Index: 1
#2Junjie Hu (GAU: Gansu Agricultural University)H-Index: 2
Last.Xingxu Zhao (GAU: Gansu Agricultural University)H-Index: 5
view all 9 authors...
Background Melatonin is an amine hormone that plays an important role in regulating mammalian reproduction. This study aimed to investigate the expression pattern of melatonin synthesis enzymes AANAT and HIOMT and melatonin receptors MT1 and MT2 in sheep cumulus–oocyte complexes (COCs) as well as the change of melatonin level in follicular fluid (FF) during antral follicle development. In this research, we also study the effect of β-estradiol (E2) on MT1 and MT2 expression as well as melatonin s...
#1Zhen-Gao Sun (SDUTCM: Shandong University of Traditional Chinese Medicine)
#2Hsun-Ming Chang (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 17
Last.Fang Lian (SDUTCM: Shandong University of Traditional Chinese Medicine)H-Index: 4
view all 8 authors...
Background Polycystic ovary syndrome (PCOS) is a complex disorder associated with multiple metabolic disturbance, including defective glucose metabolism and insulin resistance. The altered metabolites caused by the related metabolic disturbance may affect ovarian follicles, which can be reflected in follicular fluid composition. The aim of this study is to investigate follicular fluid metabolic profiles in women with PCOS using an advanced sequential window acquisition of all theoretical fragmen...
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