Amino Acids
Papers 4355
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#1Arianna De Rosa (Sapienza University of Rome)H-Index: 1
#2Francesca Mastrostefano (Sapienza University of Rome)
Last. Geppino Falco (University of Naples Federico II)H-Index: 16
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The free d-amino acid, d-aspartate, is abundant in the embryonic brain but significantly decreases after birth. Besides its intracellular occurrence, d-aspartate is also present at extracellular level and acts as an endogenous agonist for NMDA and mGlu5 receptors. These findings suggest that d-aspartate is a candidate signaling molecule involved in neural development, influencing brain morphology and behaviors at adulthood. To address this issue, we generated a knockin mouse model in which the e...
#1Ning Liu (CAU: China Agricultural University)
#2Jingqing Chen (CAU: China Agricultural University)H-Index: 4
Last. Guoyao Wu (CAU: China Agricultural University)H-Index: 99
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Dietary l-proline (proline) supplementation during gestation enhances fetal survival and placental development in mice. The objective of the present study was to test the hypothesis that this beneficial effect of proline was associated with alterations in inflammatory response at the placenta and fetus interface. Populations of immune cells present in peripheral blood mononuclear cells (PBMC) were determined by flow cytometry analysis. The concentrations of immunoglobulins in plasma, and the con...
#1Maurizio Balestrino (UniGe: University of Genoa)H-Index: 22
#2Enrico Adriano (UniGe: University of Genoa)H-Index: 8
#1Sho Kobayashi (YU: Yamagata University)H-Index: 9
#2Yoshitaka Ikeda (Saga University)H-Index: 33
Last. Junichi Fujii (YU: Yamagata University)H-Index: 52
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Some γ-glutamylpeptides in blood plasma are putative biomarkers for pathological conditions of the liver. γ-Glutamyltransferase (GGT) and γ-glutamylcysteine synthetase (γ-GCS) are two such potential enzymes that are responsible for the production of γ-glutamylpeptides. GGT produces γ-glutamylpeptides by transferring the γ-glutamyl moiety from glutathione to an amino acid or a peptide. γ-GCS normally catalyzes the production of γ-glutamylcysteine from glutamate and cysteine in the glutathione-syn...
#1Peng LiH-Index: 1
#2Guoyao Wu (A&M: Texas A&M University)H-Index: 99
We analyzed the composition of amino acids (AAs) in oligopeptides, proteins, and the free pool, as well as creatine, agmatine, polyamines, carnosine, anserine, and glutathione, in animal- and plant-derived feedstuffs. Ingredients of animal origins were black soldier fly larvae meal (BSFM), chicken by-product meal, chicken visceral digest, feather meal, Menhaden fishmeal, Peruvian anchovy fishmeal, Southeast Asian fishmeal, spray-dried peptone from enzymes-treated porcine mucosal tissues, poultry...
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#1Takumi YamaneH-Index: 8
#2Ryosuke KonnoH-Index: 1
Last. Yuichi OishiH-Index: 13
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Protein malnutrition is largely associated with a delay or failure of the healing process. However, the effect of dietary protein quality on wound healing is largely unknown. This study aimed to reveal the effect of dietary protein quality on wound healing and elucidate the regulatory mechanisms in a rat model of full-thickness cutaneous wounds. Rats were fed a normal diet for a week, and then they were divided into three groups that were fed the following diet for the experimental period: casei...
#1Jinlei Li (Zhengzhou University)
#2Kui Lu (Henan University of Technology)H-Index: 3
Last. Jianzhao Qi (WHU: Wuhan University)
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Breast cancer susceptibility gene 2 (BRCA2) is an important tumor suppressor, which is participated in repair of damaged DNA by its highly conserved BRC repeat motifs regulating RAD51 protein homologous recombination and thereby preventing cell carcinogenesis. In this study, the BRCA2(1524–1548)–RAD51(241–260) complex structure was obtained based on PDB bank data 1N0W, which provided the basis for site-specific mutation of BRCA2(1524–1548). The BRC4 and BRC4 analogous peptides were synthesized, ...
#2John M. BrameldH-Index: 22
Last. Andrew J. MurtonH-Index: 13
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Chronic mTORc1 hyperactivation via obesity-induced hyperleucinaemia has been implicated in the development of insulin resistance, yet the direct impact of leucine on insulin-stimulated glucose uptake in muscle cells remains unclear. To address this, differentiated L6 myotubes were subjected to various compounds designed to either inhibit mTORc1 activity (rapamycin), blunt leucine intracellular import (BCH), or activate mTORc1 signalling (3BDO), prior to the determination of the uptake of the glu...
#1Tetsuya MiyamotoH-Index: 7
#2Masumi KataneH-Index: 12
Last. Hiroshi HommaH-Index: 29
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Bacteria produce various d-amino acids, including non-canonical d-amino acids, to adapt to environmental changes and overcome a variety of threats. These d-amino acids are largely utilized as components of peptidoglycan, and they promote peptidoglycan remodeling and biofilm disassembly. The biosynthesis, maturation, and recycling of peptidoglycan are catalyzed by penicillin-binding proteins (PBPs). However, although non-canonical d-amino acids are known to be incorporated into peptidoglycan, the...
#2Jiancheng YangH-Index: 10
Last. Jianmin HuH-Index: 10
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The calpain-1-activated apoptotic pathway plays a key role in right ventricular hypertrophy (RVH). Taurine has been shown to attenuate apoptosis by inhibiting calpain activity. This experiment aimed to determine whether taurine could prevent RVH by inhibiting the calpain-1/cytochrome c apoptotic pathway. The broilers were given 1% taurine dissolved in drinking water and were raised at 10 °C ~ 12 °C from day 21 to day 42. At 21 d, 28 d, 35 d and 42 d, the right ventricular (RV) tissues were colle...
Top fields of study
Amino acid