Laboratory Investigation
Papers 9904
1 page of 991 pages (9,904 results)
#1Fanyun KongH-Index: 5
#2Nan LiH-Index: 1
Last. Hongjuan YouH-Index: 5
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Neuraminidase 1 (NEU1) has been reported to be associated with hepatocellular carcinoma (HCC). However, the function and associated molecular mechanisms of NEU1 in hepatitis B virus (HBV)-related HCC have not been well investigated. In the present study, the expression of NEU1 mediated by HBV and HBV core protein (HBc) was measured in hepatoma cells. The expression of NEU1 protein was detected via immunohistochemical analysis in HBV-associated HCC tissues. The role of NEU1 in the activation of s...
#1Yifan Yang (Fudan University)H-Index: 5
#2Junfeng Wang (Fudan University)H-Index: 1
Last. Rui Dong (Fudan University)H-Index: 14
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Exposure to environmental toxins may be responsible for biliary atresia. The focus of this study was to investigate the effect of biliatresone on the development of the hepatobiliary system in mice. We successfully synthesized biliatresone with a purity of 98% and confirmed its biliary toxicity. Exposure to high doses of biliatresone caused abortion or death in pregnant mice. Neonatal mice injected with biliatresone developed clinical signs of biliary obstruction, and dysplasia or the absence of...
#1Amit Gupta (UConn: University of Connecticut)
#2Sandhya Yadav (Indian Institute of Science Education and Research, Bhopal)H-Index: 3
Last. Sanjeev Shukla (Indian Institute of Science Education and Research, Bhopal)H-Index: 10
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The deregulation of splicing factors and alternative splicing are increasingly viewed as major contributory factors in tumorigenesis. In this study, we report overexpression of a key splicing factor, heterogeneous nuclear ribonucleoprotein A2B1 (HNRNPA2B1), and thereby misregulation of alternative splicing, which is associated with the poor prognosis of head and neck cancer (HNC). The role of HNRNPA2B1 in HNC tumorigenesis via deregulation of alternative splicing is not well understood. Here, we...
#1Mousumi Roy (SBU: Stony Brook University)H-Index: 2
#2Fusheng Wang (SBU: Stony Brook University)H-Index: 26
Last. Jun KongH-Index: 24
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Hepatic steatosis droplet quantification with histology biopsies has high clinical significance for risk stratification and management of patients with fatty liver diseases and in the decision to use donor livers for transplantation. However, pathology reviewing processes, when conducted manually, are subject to a high inter- and intra-reader variability, due to the overwhelmingly large number and significantly varying appearance of steatosis instances. This process is challenging as there is a ...
#2Edana StrobergH-Index: 1
Last. Michael KupermanH-Index: 6
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Coronavirus Disease-19 (COVID-19), caused by the coronavirus SARS-CoV-2, was initially recognized in Wuhan, China and subsequently spread to all continents. The disease primarily affects the lower respiratory system, but may involve other organs and systems. Histopathologic evaluation of tissue from affected patients is crucial for diagnostic purposes, but also for advancing our understanding of the disease. For that reason, we developed immunohistochemical (IHC) and in situ hybridization (ISH) ...
#1Ikumi Kitazono (Kadai: Kagoshima University)H-Index: 4
#2Taiji Hamada (Kadai: Kagoshima University)H-Index: 6
Last. Akihide Tanimoto (Kadai: Kagoshima University)H-Index: 33
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Purkinje cell protein 4/peptide 19 (PCP4/PEP19) is 7.6 kDa peptide originally found in Purkinje cells. PCP4/PEP19 is a differentiation maker of Purkinje cells, where it functions as an antiapoptotic factor. Cerebral neuronal cells also express PCP4/PEP19, which may be related to neuronal cell survival. However, evidence suggests that PCP4/PEP19 may also be involved in neuronal differentiation. Here, we investigated the effects of PCP4/PEP19 expression on neuronal differentiation by analyzing neu...
#1Huaxun Wu (Anhui Medical University)H-Index: 16
#2Xiaoyun Chen (Anhui Medical University)H-Index: 4
Last. Heinrich Körner (Anhui Medical University)H-Index: 40
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The etiology of primary Sjogren’s syndrome (pSS) remains unknown, and there is no complete curative drug. In this study, we treated a mouse model of the submandibular gland (SG) protein-immunized experimental Sjogren’s syndrome (ESS) with paeoniflorin-6′-O-benzene sulfonate (termed CP-25) to evaluate the potential therapeutic effects of CP-25. Through in vivo experiments, we found that CP-25 increased saliva flow, alleviated the salivary gland indexes, and improved tissue integrity in the ESS mo...
#1Thibaud Koessler (Geneva College)H-Index: 9
#2Viola ParadisoH-Index: 2
Last. Thomas Alexander Mckee (Geneva College)H-Index: 19
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Liquid biopsy, the analysis of circulating tumor DNA (ctDNA), is a promising tool in oncology, especially in personalized medicine. Although its main applications currently focus on selection and adjustment of therapy, ctDNA may also be used to monitor residual disease, establish prognosis, detect relapses, and possibly screen at-risk individuals. CtDNA represents a small and variable proportion of circulating cell-free DNA (ccfDNA) which is itself present at a low concentration in normal indivi...
#1K Irungbam (University of Giessen)H-Index: 3
#2Martin Roderfeld (University of Giessen)H-Index: 19
Last. Imanuel Yüce (University of Giessen)H-Index: 3
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Clinical studies demonstrated that nonalcoholic steatohepatitis is associated with liver-related outcomes in chronic hepatitis B. Furthermore, primary biliary fibrosis and biliary atresia occurred in patients with HBV infection. Interestingly, hepatitis B virus surface protein (HBs) transgenic mice spontaneously develop hepatic steatosis. Our aim is to investigate the effect of Abcb4 knockout-induced cholestasis on liver steatosis in HBs transgenic mice. Hybrids of HBs transgenic and Abcb4−/− mi...
#1Xiaofeng Shi (Tianjin First Center Hospital)H-Index: 1
#2Wei Ma (Dalian Medical University)H-Index: 1
Last. Lei Li (Dalian Medical University)H-Index: 1
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Abdominal aortic aneurysm (AAA) is a potential lethal disease that is defined by an irreversible dilatation (>50%) of the aorta. During AAA expansion, the aortic wall is often remodeled, which is featured by extracellular matrix (ECM) degeneration, medial and adventitial inflammation, depletion and phenotypic switching of vascular smooth muscle cells (SMCs). Recent studies have suggested microRNAs as vital regulators for vascular SMC function. Our earlier work demonstrated an anti-AAA role of mi...
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