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#1Guo Liya (Capital Medical University)
#2Wang Yuguang (Capital Medical University)H-Index: 1
Last. Jiao Yiqing (Capital Medical University)
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Summary Coronaviruses are a class of RNA viruses that can cause respiratory and intestinal infections in animals and humans. SARS-CoV, MERS-CoV and a novel coronavirus (SARS-CoV-2 [2019-nCoV]) belong to the family Coronaviridae and the genus Betacoronavirus. At present, the understanding of SARS-CoV-2 is getting deeper and deeper. In order to better prevent and treat SARS-CoV-2, this article compares the infectivity, pathogenicity, and related clinical characteristics of the three human pathogen...
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#1Jennifer Bunke (CAU: University of Kiel)
#2Kerstin Receveur (CAU: University of Kiel)H-Index: 1
Last. Andi Krumbholz (CAU: University of Kiel)H-Index: 6
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Summary Bacteria and viruses were analysed in the upper respiratory tract of symptomatic pig-farmers and their domestic pigs. 86 human nasal and 495 (50 pools) porcine snout swabs were collected in Schleswig-Holstein, Germany. Staphylococcus (S.) aureus (62.8%, 54/86), human rhino- and coronaviruses (HRV, 29.1%, 25/86; HCoV, 16.3%, 14/86) were frequently detected in humans while Haemophilus parasuis (90.0%, 45/50), Mycoplasma hyorhinis (78.6%, 11/14), Enterovirus G (EV-G, 56.0%, 28/50), and S. a...
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#1Steffen Leth (Aarhus University Hospital)H-Index: 5
#1S. Leth (Aarhus University Hospital)
Last. S. Jensen‐Fangel (Aarhus University Hospital)
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Exhausted and dysfunctional T cells triggered by infection and cancer renders the immune system unable to eliminate these pathogens. Pharmacologic blockade of the surface receptors that inhibit T cell function has shown remarkable success in patients with various malignancies. In this Review, we discuss the emerging evidence of inhibiting checkpoint pathways as a potential role in controlling or clearing infectious diseases. Though interesting tendencies, much work is still needed in order to de...
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#1Mathilde Kjeldsen (UCPH: University of Copenhagen)
#2Preben Homøe (UCPH: University of Copenhagen)H-Index: 18
Last. Thomas Bjarnsholt (UCPH: University of Copenhagen)H-Index: 52
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PURPOSE: To evaluate the eradicative effect of acetic acid on bacterial biofilm grown on tympanostomy tubes by an in vitro experiment. METHODS: Biofilms of Pseudomonas aeruginosa and Staphylococcus aureus were grown on sterile tympanostomy tubes for 24 hours. The tubes were treated with acetic acid solutions at various concentrations for 24 hours. Main outcome was viability of bacteria after treatment. Presence of consistently attached biofilm was examined on selected tympanostomy tubes with con...
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#1Özlem Kesmez (UCPH: University of Copenhagen)
#2Metha Juhl Frøjk (Copenhagen University Hospital)
Last. Camilla Kragelund (UCPH: University of Copenhagen)H-Index: 7
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OBJECTIVE: To investigate oral health in randomly selected patients with chronic kidney disease (CKD). MATERIAL AND METHODS: Data obtained by structured interview (self-reported lifestyle, oral symptoms, and regularity of dental visits) and oral examination of patients with CKD from the Copenhagen University Hospital. RESULTS: Fourteen patients with CKD were screened. Only half of the patients reported regular dental visits and poor dental status was registered in half of the patients. Oral muco...
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#1Ronza Hadad (Örebro University)H-Index: 6
#2Jørgen Skov Jensen (SSI: Statens Serum Institut)H-Index: 53
Last. Marianne Nielsine Skov (OUH: Odense University Hospital)H-Index: 26
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Chlamydia trachomatis infection is the most common bacterial sexually transmitted infection globally, and nucleic acid amplification tests (NAATs) are recommended for highly sensitive and specific diagnosis. In early 2019, the Finnish new variant of Chlamydia trachomatis (FI-nvCT) was identified. The FI-nvCT has a C1515T mutation in the 23S rRNA gene, making it escaping detection in the Aptima Combo 2 (AC2; Hologic) NAAT, and the FI-nvCT has been subsequently reported in Sweden and Norway. In th...
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#1R. Talotta (UNIME: University of Messina)H-Index: 2
#2Fabiola Atzeni (UNIME: University of Messina)H-Index: 48
Last. Magdalena Janina Laska (Aarhus University Hospital)
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INTRODUCTION/AIM: Human endogenous retroviruses (HERVs)-E consist of a family of more than 1,300 elements, stably integrated in the human genome. Some of them are able to generate full-length virions and to synthesize the viral proteins gag, pol and env. The reactivation of HERV-E elements has been associated to placentation, cancer and autoimmunity. In this narrative review we aimed to report the status of the art concerning the involvement of HERV-E in rheumatic autoimmune diseases. METHODS/RE...
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#1Bruno Vincent Luukinen (UH: University of Helsinki)H-Index: 1
#2Risto VuentoH-Index: 22
Last. J. J. HirvonenH-Index: 3
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In areas of low tuberculosis (TB) prevalence, laboratory diagnosis of TB may essentially cover non-tuberculous mycobacteria (NTM) in addition to Mycobacterium tuberculosis (MTB). In this study, a semi-automated PCR workflow distinguishing MTB and NTM (Anyplex(TM) MTB/NTMe, Seegene) and subsequently detecting MTB isoniazid/rifampicin resistance (Allplex(TM) MTB/MDRe, Seegene) was evaluated for replacing smear microscopy of acid-fast bacilli as the rapid screening method for TB. With 279 clinical ...
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#1Madhura Patankar (University of Oulu)H-Index: 1
#2Taneli Mattila (University of Oulu)
Last. Tuomo J. Karttunen (University of Oulu)H-Index: 42
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Anoikis is a form of apoptosis where a cell loses contact with the extracellular matrix (ECM). Anoikis resistance is essential for metastasis formation, yet only detectable by in vitro experiments. We present a method for quantitation of putative anoikis-resistant (AR) subpopulations in colorectal carcinoma (CRC) and evaluate their prognostic significance. We studied 137 CRC cases and identified cell subpopulations with and without stromal or extracellular matrix (ECM) contact with hematoxylin a...
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#1Maria del Pilar Quintana (UCPH: University of Copenhagen)H-Index: 4
#2Cecilia Smith-Togobo (UCPH: University of Copenhagen)H-Index: 1
Last. Lars Hviid (UCPH: University of Copenhagen)H-Index: 50
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Burkitt lymphoma (BL) is an aggressive non-Hodgkin lymphoma. The prevalence of BL is ten-fold higher in areas with stable transmission of Plasmodium falciparum malaria, where it is the most common childhood cancer, and is referred to as endemic BL (eBL). In addition to its association with exposure to P. falciparum infection, eBL is strongly associated with Epstein-Barr virus (EBV) infection (>90%). This is in contrast to BL as it occurs outside P. falciparum-endemic areas (sporadic BL), where o...
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