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Thrombosis Research
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#1Sophie Jones (University of Melbourne)H-Index: 6
#2Paul Monagle (University of Melbourne)H-Index: 45
Last. Fiona NewallH-Index: 22
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Abstract Asymptomatic venous thrombosis is a common complication among hospitalised paediatric patients. Previous guidelines recommend the treatment of all asymptomatic venous thrombosis, even when the diagnosis is made incidentally or the risk factor is no longer present. Whether clinicians need to treat all asymptomatic thrombosis in children, given the likelihood of long-term sequelae, is unclear and there are significant risks associated with anticoagulation treatment. Asymptomatic thrombosi...
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#1Gili Kenet (Sheba Medical Center)H-Index: 31
#2Rolf Ljung (Lund University)H-Index: 39
Last. Nikki Church (Bayer)H-Index: 1
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Abstract Introduction BAY 81-8973 (Kovaltry®), a recombinant factor VIII (rFVIII) product, was efficacious and well tolerated in paediatric previously treated patients (PTPs) with severe haemophilia A for ≥50 exposure days (EDs) in the LEOPOLD Kids study. Because long-term prophylaxis (≥100 EDs) can provide substantial patient benefits, FVIII products should demonstrate long-term safety and efficacy. Aim To demonstrate long-term (≥100 EDs) efficacy and safety of BAY 81-8973 in paediatric PTPs. M...
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#1Ya Tan (PKU: Peking University)H-Index: 1
#2Kai Yang (PKU: Peking University)H-Index: 43
Last. Li Lin (PKU: Peking University)
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Abstract Background The value of D-dimer testing for the diagnosis of thrombosis in unusual sites is not properly established and evidence is scarce. We performed a systematic review of the literature. Methods The search was conducted in MEDLINE and Cochrane Library for papers published in the last 10 years including different presentations of thrombosis in unusual sites. Twenty-three articles were included, from January 1, 2008, to December 31, 2018, comprising 3378 patients with thrombosis in ...
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#1J. Spencer Dingman (Wesley Medical Center)
#1J. Spencer Dingman (Wesley Medical Center)H-Index: 1
Last. Long ToH-Index: 2
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Abstract Argatroban is a parenteral direct thrombin inhibitor that requires close monitoring to ensure safety and efficacy. Limited data exist to describe its effect in critically ill patients. This was a retrospective, single-center, cohort study that aimed to compare argatroban dosing requirements in those receiving extracorporeal life support (ECLS), continuous renal replacement therapy (CRRT), or neither. Organ dysfunction was assessed using a modified version of the Sequential Organ Failure...
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#2Andrew Y. Koh (UTSW: University of Texas Southwestern Medical Center)H-Index: 16
Last. Ayesha ZiaH-Index: 6
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Abstract The gut microbiome plays a critical role in various inflammatory conditions, and its modulation is a potential treatment option for these conditions. The role of the gut microbiome in the pathogenesis of thromboembolism has not been fully elucidated. In this review, we summarize the evidence linking the gut microbiome to the pathogenesis of arterial and venous thrombosis. In a human host, potentially pathogenic bacteria are normal residents of the human gut microbiome, but significantly...
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#2Joanna Natorska (Jagiellonian University Medical College)H-Index: 9
Last. Anetta UndasH-Index: 41
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#1Weronika Adach (University of Łódź)H-Index: 1
#2Beata Olas (University of Łódź)H-Index: 28
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Abstract Introduction von Willebrand disease (VWD) is the most common inherited bleeding disorder and may alternatively arise as an acquired condition (AVWS). These represent deficiency and/or defects in von Willebrand factor (VWF). Closure times (CTs) obtained from the platelet function analyser (PFA) are highly sensitive to both VWD/AVWS. The current study has evaluated the utility of the PFA-100/-200 to exclude or detect laboratory identified VWD. Materials and methods An evaluation of the su...
1 CitationsSource
#1Mika OgawaH-Index: 3
#2Nobuaki SuzukiH-Index: 6
Last. Toshihisa KojimaH-Index: 17
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