Abstract Background Variation in patient characteristics and practice patterns may influence outcomes at a regional level. Methods We assessed differences in demographics, practice patterns, outcomes, and the effect of apixaban compared with warfarin in ARISTOTLE (n = 18,201) by prespecified regions: North America, Latin America, Europe, and Asia Pacific. The primary outcomes were stroke/systemic embolism and major bleeding. Results Compared with other regions, patients from Asia Pacific were yo...
Abstract Background Previous studies indicated that inhibiting the cardiac autonomic nervous system (CANS) suppressed atrial fibrillation (AF). Clinical research revealed serum adiponectin (APN) exerted a beneficial influence on sympathetic and vagal tone in patients with type 2 diabetes. However, the effects of APN on CANS is unknown. This study aims to investigate whether APN could regulate CANS and suppress rapid atrial pacing (RAP)-induced AF. Methods Eighteen beagles were divided into the c...
Abstract Background To determine the effect of atrial pacing on the rate of post-operative atrial fibrillation (POAF) following coronary artery bypass grafting. Methods After a systematic literature search, randomized clinical trials (RCTs) comparing any combination of no pacing (NP), bi-atrial (BiA) pacing, left-atrial (LA) pacing and right-atrial (RA) pacing were included. Pairwise and network meta-analyses were performed using the generic inverse variance method. The primary outcome was POAF ...
Abstract Background To clarify the influence of hemoglobin concentration and platelet count on adverse outcomes of Japanese patients with non-valvular atrial fibrillation (NVAF), a post hoc analysis of the J-RHYTHM Registry was performed. Methods A consecutive series of outpatients with atrial fibrillation were enrolled from 158 institutions and followed up for 2 years or until an event occurred (thromboembolism, major hemorrhage, or all-cause death). Among 7406 patients with NVAF, 6536 with com...
Abstract Background The optimal cutoff for systolic blood pressure (SBP) level to define high-risk pulmonary embolism (PE) remains to be defined. Methods To evaluate the relationship between SBP levels on admission and mortality in patients with acute symptomatic PE, the current study included 39,257 consecutive patients with acute symptomatic PE from the RIETE registry between 2001 and 2018. Primary outcomes included all-cause and PE-specific 30-day mortality. Secondary outcomes included major ...
Abstract Backgrounds The prevalence of atrial fibrillation (AF) has been increasing in aging societies. The prognostic impact of AF associated with worsening heart failure (HF) remains obscure. Methods and results We analyzed 1170 acute heart failure (AHF) patients who required intensive care. Patients were assigned to two groups according to the prevalence of AF: no episode of AF (n = 940) and pre-existing AF (Group-1, n = 230). Patients with no episode of AF (n = 940) were further divided into...
#2Piotr Jankowski(Jagiellonian University Medical College)H-Index: 19
Last.Kornelia Kotseva(NIH: National Institutes of Health)H-Index: 27
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Abstract Objective Assess the dietary recommendations provided to patients hospitalized for a coronary heart disease (CHD) event. Design Cross-sectional, multicentre observational study (ESC EORP Euroaspire V). Methods 8261 participants (25.8% women, 9.3% aged Results Advice to reduce energy intake, salt, fat and sugar was provided to 64.5% [range: 9.2–90.5], 73.2% [38.6–95.2], 77.3% [42.3–95.6] and 67.0% [39.4–93.3] of patients, respectively. Advice to change fat type, increase consumption of p...