Current Biology
IF
9.25
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17127
Papers 17100
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Published on Mar 1, 2019in Current Biology 9.25
Kohar Annie Kissoyan1
Estimated H-index: 1
,
Moritz Drechsler1
Estimated H-index: 1
+ 4 AuthorsKatja Dierking8
Estimated H-index: 8
1 Citations Source Cite
Published on Jan 1, 2019in Current Biology 9.25
Valentina Rausch (University of Edinburgh), Jonathan R. Bostrom3
Estimated H-index: 3
(Medical College of Wisconsin)
+ 5 AuthorsCarsten Gram Hansen13
Estimated H-index: 13
(University of Edinburgh)
Summary The Hippo pathway plays major roles in development, regeneration, and cancer. Its activity is tightly regulated by both diffusible chemical ligands and mechanical stimuli. The pathway consists of a series of kinases that can control the sub-cellular localization and stability of YAP or TAZ, homologous transcriptional co-factors. Caveolae, small (60–100 nm) bulb-like invaginations of the plasma membrane, are comprised predominantly of caveolin and cavin proteins and can respond to mechani...
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Published on Feb 1, 2019in Current Biology 9.25
Mélissa Glatigny (Paris Descartes University), Stéphanie Moriceau2
Estimated H-index: 2
(Paris Descartes University)
+ 14 AuthorsAllyson K. Friedman1
Estimated H-index: 1
(City University of New York)
Summary Age-related declines in cognitive fitness are associated with a reduction in autophagy, an intracellular lysosomal catabolic process that regulates protein homeostasis and organelle turnover. However, the functional significance of autophagy in regulating cognitive function and its decline during aging remains largely elusive. Here, we show that stimulating memory upregulates autophagy in the hippocampus. Using hippocampal injections of genetic and pharmacological modulators of autophagy...
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Published on Jan 1, 2019in Current Biology 9.25
Chloe Moreau1
Estimated H-index: 1
(Pasteur Institute),
Paolo Caldarelli1
Estimated H-index: 1
(Pasteur Institute)
+ 4 AuthorsJerome Gros16
Estimated H-index: 16
(Pasteur Institute)
Summary Limb position along the body is highly consistent within one species but very variable among vertebrates. Despite major advances in our understanding of limb patterning in three dimensions, how limbs reproducibly form along the antero-posterior axis remains largely unknown. Hox genes have long been suspected to control limb position; however, supporting evidences are mostly correlative and their role in this process is unclear. Here, we show that limb position is determined early in deve...
2 Citations Source Cite
Published on Feb 1, 2019in Current Biology 9.25
Wouter Smet3
Estimated H-index: 3
(Ghent University),
Iris Sevilem5
Estimated H-index: 5
(University of Helsinki)
+ 11 AuthorsMark V. Boekschoten22
Estimated H-index: 22
(Wageningen University and Research Centre)
Summary To create a three-dimensional structure, plants rely on oriented cell divisions and cell elongation. Oriented cell divisions are specifically important in procambium cells of the root to establish the different vascular cell types [ 1 , 2 ]. These divisions are in part controlled by the auxin-controlled TARGET OF MONOPTEROS5 (TMO5) and LONESOME HIGHWAY (LHW) transcription factor complex [ 3 , 4 , 5 , 6 , 7 ]. Loss-of-function of tmo5 or lhw clade members results in strongly reduced vascu...
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Published on Jan 1, 2019in Current Biology 9.25
Carmen Wong4
Estimated H-index: 4
(University of Western Ontario),
Stephen G. Lomber38
Estimated H-index: 38
(University of Western Ontario)
Summary In complex environments, information about surrounding obstacles is stored in working memory (WM) and used to coordinate appropriate movements for avoidance. In quadrupeds, this WM system is particularly important for guiding hindleg stepping, as an animal can no longer see the obstacle underneath the body following foreleg clearance. Such obstacle WM involves the posterior parietal cortex (PPC), as deactivation of area 5 incurs WM deficits, precluding successful avoidance. However, the ...
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Published on Mar 1, 2019in Current Biology 9.25
Jaco Barendse , Alison Roel + 4 AuthorsFrancis Neat22
Estimated H-index: 22
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Published on Jan 1, 2019in Current Biology 9.25
Chu Chen (University of Michigan), Ian P. Whitney1
Estimated H-index: 1
(Massachusetts Institute of Technology)
+ 8 AuthorsIain M. Cheeseman46
Estimated H-index: 46
(Massachusetts Institute of Technology)
Summary Switch-like activation of the spindle assembly checkpoint (SAC) is critical for accurate chromosome segregation and for cell division in a timely manner. To determine the mechanisms that achieve this, we engineered an ectopic, kinetochore-independent SAC activator: the "eSAC." The eSAC stimulates SAC signaling by artificially dimerizing Mps1 kinase domain and a cytosolic KNL1 phosphodomain, the kinetochore signaling scaffold. By exploiting variable eSAC expression in a cell population, w...
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Published on Jan 1, 2019in Current Biology 9.25
Rajesh Kumar Singh10
Estimated H-index: 10
(Swedish University of Agricultural Sciences),
Pál Miskolczi18
Estimated H-index: 18
(Swedish University of Agricultural Sciences)
+ 1 AuthorsRishikesh P. Bhalerao41
Estimated H-index: 41
(Swedish University of Agricultural Sciences)
Summary Perennials in boreal and temperate ecosystems display seasonally synchronized growth. In many tree species, prior to the advent of winter, exposure to photoperiods shorter than a critical threshold for growth (short days; SDs) induces growth cessation, culminating in the formation of an apical bud that encloses the shoot apical meristem and arrested leaf primordia [ 1 , 2 , 3 , 4 ]. Following growth cessation, subsequent exposure to SDs induces transition to dormancy in the shoot apex [ ...
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Published on Jan 1, 2019in Current Biology 9.25
Richard Courtemanche14
Estimated H-index: 14
,
Amanda Cammalleri
Summary The basal ganglia integrate motivation and action across their circuits; neurons in anatomical modules called striosomes could contribute strongly to this merger. A new method focusing on network interconnections will allow a better understanding of the functional role of striosomes.
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