Current Biology
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#1Elizabeth G. Wheatley (UCSF: University of California, San Francisco)H-Index: 4
#2Eddy Albarran (Stanford University)H-Index: 2
Last.Saul A. VilledaH-Index: 16
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Summary Mounting evidence in animal models indicates potential for rejuvenation of cellular and cognitive functions in the aging brain. However, the ability to utilize this potential is predicated on identifying molecular targets that reverse the effects of aging in vulnerable regions of the brain, such as the hippocampus. The dynamic post-translational modification O-linked N-Acetylglucosamine (O-GlcNAc) has emerged as an attractive target for regulating aging-specific synaptic alterations as w...
#1Konner Winkley (KSU: Kansas State University)H-Index: 1
#2Spencer Ward (KSU: Kansas State University)
Last.Michael Veeman (KSU: Kansas State University)H-Index: 5
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Summary The notochord of the invertebrate chordate Ciona forms a tapered rod at tailbud stages consisting of only 40 cylindrical cells in a single-file column. This tapered shape involves differences in notochord cell volume along the anterior-posterior axis. Here, we quantify sibling cell volume asymmetry throughout the developing notochord and find that there are distinctive patterns of unequal cleavage in all 4 bilateral pairs of A-line primary notochord founder cells and also in the B-line-d...
#1Scott William Roy (SFSU: San Francisco State University)H-Index: 37
#2Bradley A. Bowser (UCM: University of California, Merced)
Summary A close relative of vertebrates solves the problem of gene-disrupting transposable element insertions by splicing them out at the RNA level. Why is such an elegant solution so rare across eukaryotes?
#1Ying Ma (Imperial College London)H-Index: 4
#2Giulia Miracca (Imperial College London)H-Index: 3
Last.William Wisden (Imperial College London)H-Index: 59
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Summary Our urge to sleep increases with time spent awake, until sleep becomes inescapable. The sleep following sleep deprivation is longer and deeper, with an increased power of delta (0.5–4 Hz) oscillations, a phenomenon termed sleep homeostasis [ 1 , 2 , 3 , 4 ]. Although widely expressed genes regulate sleep homeostasis [ 1 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ] and the process is tracked by somnogens and phosphorylation [ 1 , 3 , 7 , 11 , 12 , 13 , 14 ], at the circuit level sleep homeostasis has r...
#1Connor J. Balzer (UO: University of Oregon)H-Index: 1
#2Andrew R. Wagner (UO: University of Oregon)H-Index: 2
Last.Brad J. Nolen (UO: University of Oregon)H-Index: 14
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Summary Arp2/3 complex nucleates branched actin filaments important for cellular motility, endocytosis, meiosis, and cellular differentiation [ 1 , 2 , 3 , 4 ]. Wiskott-Aldrich syndrome proteins (WASPs), the prototypical Arp2/3 complex activators, activate Arp2/3 complex only once it is bound to the side of an actin filament [ 5 , 6 ]. This ensures WASP-activated Arp2/3 complex only nucleates branched actin filaments but means branched actin networks must be seeded with an initial preformed fila...
#1Takuma Hiwatashi (Kobe University)H-Index: 1
#2Honzhen Goh (NUS: National University of Singapore)H-Index: 1
Last.Taisuke Togawa (Kindai University)H-Index: 1
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Summary Many plants can reproduce vegetatively, producing clonal progeny from vegetative cells; however, little is known about the molecular mechanisms underlying this process. Liverwort (Marchantia polymorpha), a basal land plant, propagates asexually via gemmae, which are clonal plantlets formed in gemma cups on the dorsal side of the vegetative thallus [ 1 ]. The initial stage of gemma development involves elongation and asymmetric divisions of a specific type of epidermal cell, called a gemm...
#1Jeffrey Podos (UMass: University of Massachusetts Amherst)H-Index: 32
Summary Sexual selection in many animal species favors the evolution of elaborate courtship traits. Such traits might help signalers convey, and receivers discern, information about signaler quality; or they might be favored by perceptual or aesthetic preferences for elaborateness or beauty 1 , 2 , 3 . Under either scenario we expect sexual trait elaboration to be countered by proximate constraints rooted in animals’ morphology, physiology and phylogenetic history 3 , 4 . During expeditions to a...
Summary The human population is shaping the planet like never before. Although this transformation started with agriculture, the focus is now switching to cities as humanity is rapidly becoming more urbanised. Thus, the environmental and sustainability challenges of this century will all have to be addressed in the context of more than 4 billion people living in cities. Michael Gross reports.