European Journal of Immunology
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#1Sandra C. Côté (Ottawa Hospital Research Institute)H-Index: 2
#2Stephanie C Burke Schinkel (Ottawa Hospital Research Institute)H-Index: 1
Last. Jonathan B. Angel (Ottawa Hospital Research Institute)H-Index: 35
view all 8 authors...
The IL-7 receptor specific alpha chain, CD127, can be expressed both as a membrane-associated (mCD127) and a soluble form (sCD127), however, the mechanisms involved in their regulation remain to be defined. We first demonstrated in primary human CD8(+) T cells that IL-7-induced downregulation of mCD127 expression is dependent on JAK and PI3K signalling, whereas IL-7-induced sCD127 release is also mediated by STAT5. Following stimulation with IL-7, expression of alternatively spliced variants of ...
#1Yohannes Haile (U of A: University of Alberta)H-Index: 6
#2Adeolu Adegoke (U of A: University of Alberta)
Last. Colin C. Anderson (U of A: University of Alberta)H-Index: 25
view all 5 authors...
Lymphocyte depletion using anti-CD52 antibody effectively reduces relapses of multiple sclerosis (MS). To begin to understand what mechanisms might control this outcome, we examined the effect of a murine-CD52 specific monoclonal antibody on the depletion and repopulation of immune cells in mice with experimental autoimmune encephalomyelitis (EAE), a model of MS. We tested whether the tolerance-promoting receptor PD-1 is required for disease remission post anti-CD52; and found that PD-1 deficien...
#1Astrid A. Bovens (UvA: University of Amsterdam)
#2Thomas H. Wesselink (UvA: University of Amsterdam)H-Index: 2
Last. Regina Stark (Humboldt University of Berlin)
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Invariant natural killer T cells (iNKT) constitute up to 50% of liver lymphocytes and contribute to immunosurveillance as well as pathogenesis of the liver. Systemic activation of iNKT cells induces acute immune-mediated liver injury. However, how tissue damage events regulate iNKT cell function and homeostasis remains unclear. We found that specifically tissue-resident iNKT cells in liver and spleen express the tissue-damage receptor P2RX7 and the P2RX7-activating ectoenzyme ARTC2. P2RX7 expres...
#1Dominic Boardman (UBC: University of British Columbia)H-Index: 8
#2Rosa Garcia (UBC: University of British Columbia)H-Index: 6
Last. Megan K. Levings (UBC: University of British Columbia)H-Index: 51
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Inflammatory bowel diseases (IBD) are chronic conditions that result from uncontrolled intestinal inflammation. Pathogenic Th17 cells, characterised by production of IL-17A in the absence of IL-10, are thought to contribute to this inflammation, but in humans, antibody-mediated blockade of IL-17A is an ineffective IBD therapy whereas IL-23 blockade is effective. Here, we investigated the effects of pharmacological inhibition of RORC2, the Th17 cell lineage-defining transcription factor, on in vi...
#1Regina K. RoweH-Index: 6
#2David M. Pyle (UTSW: University of Texas Southwestern Medical Center)H-Index: 53
Last. Michelle A. Gill (UTSW: University of Texas Southwestern Medical Center)H-Index: 18
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Rhinovirus (RV) infections are linked to the development and exacerbation of allergic diseases including allergic asthma. IgE, another contributor to atopic disease pathogenesis, has been shown to regulate dendritic cell antiviral functions and influence T cell priming by monocytes. We previously demonstrated that IgE-mediated stimulation of monocytes alters multiple cellular functions including cytokine secretion, phagocytosis, and influenza-induced Th1 development. In this study, we investigat...
#1Shoba Amarnath (Newcastle University)H-Index: 16
#2Marnie L. Brown (Newcastle University)
The immune system is tightly regulated by a subset of T cells defined as regulatory T cells (Tregs). Tregs maintain immune homeostasis by restraining unwarranted immune cell activation and effector function. Here we discuss an important but under-appreciated role of proteases in controlling Treg function. Proteases regulate a number of vital processes that determine T cell immune responses and some of them such as furin, ADAM (through regulating LAG receptor), MALT and asparaginyl endopeptidase ...
#1Connor J. Dwyer (MUSC: Medical University of South Carolina)H-Index: 3
#2Dimitrios C. Arhontoulis (MUSC: Medical University of South Carolina)H-Index: 1
Last. David M. Neskey (MUSC: Medical University of South Carolina)H-Index: 10
view all 11 authors...
Adoptive T cell transfer therapy induces objective responses in patients with advanced malignancies. Despite these results, some individuals do not respond due to the generation of terminally differentiated T cells during the expansion protocol. As the gamma and delta catalytic subunits in the PI3K pathway are abundant in leukocytes and involved in cell activation, we posited that blocking both subunits ex vivo with the inhibitor IPI-145 would prevent their differentiation, thereby increasing an...
#1Agnès Garcias López (DTU: Technical University of Denmark)
#2Vasileios Bekiaris (DTU: Technical University of Denmark)H-Index: 14
Last. Meredith O'Keeffe (Monash University)H-Index: 38
view all 13 authors...
Initiation of adaptive immunity to particulate antigens in lymph nodes largely depends on their presentation by migratory dendritic cells (DCs). DC subsets differ in their capacity to induce specific types of immunity, allowing subset-specific DC-targeting to influence vaccination and therapy outcomes. Faithful drug design, however, requires exact understanding of subset-specific versus global activation mechanisms. cDC1, the subset of DCs that excel in supporting immunity towards viruses, intra...
#1Marion PinheiroH-Index: 1
#2Marie TamagneH-Index: 4
Last. Benoît VingertH-Index: 12
view all 5 authors...
Top fields of study
Molecular biology
T cell