Papers 15418
1 page of 1,542 pages (15.4k results)
Published on Dec 1, 2019in Bone4.36
Daniel G. Whitney5
Estimated H-index: 5
(UM: University of Michigan),
Daniel Whibley1
Estimated H-index: 1
(UM: University of Michigan),
Karl J. Jepsen44
Estimated H-index: 44
(UM: University of Michigan)
Abstract Background Individuals with neurodevelopmental disabilities (NDDs) have poor development and preservation of skeletal health throughout the lifespan, and are especially vulnerable to low-trauma fracture and post-fracture health complications. However, no studies have examined if adults with NDDs have greater post-fracture mortality risk compared to adults without NDDs. The purpose of this study was to determine whether adults with NDDs have greater 12-month mortality rates following a l...
Published on Dec 1, 2019in Bone4.36
Suk Hee Lee6
Estimated H-index: 6
(KNU: Kyungpook National University),
Seunghoon Lee4
Estimated H-index: 4
(KNU: Kyungpook National University)
+ 2 AuthorsJung-Eun Kim24
Estimated H-index: 24
(KNU: Kyungpook National University)
Abstract Mitochondria are not only responsible for cellular energy production but are also involved in signaling, cellular differentiation, cell death, and aging. Mitochondrial NADP+-dependent isocitrate dehydrogenase (IDH2) catalyzes the decarboxylation of isocitrate to α-ketoglutarate, accompanied by NADPH production. IDH2 plays a central role in mitochondrial function in multiple cell types and various organs, including the heart, kidneys, and brain. However, the function of IDH2 in bone tiss...
Published on Aug 1, 2019in Bone4.36
Hongyuan Jiang1
Estimated H-index: 1
(Royal Melbourne Hospital),
Dale Robinson3
Estimated H-index: 3
(University of Melbourne)
+ 5 AuthorsJohn D. Wark63
Estimated H-index: 63
(Royal Melbourne Hospital)
Abstract Dual energy X-ray absorptiometry, the current clinical criterion method for osteoporosis diagnosis, has limitations in identifying individuals with increased fracture risk, especially at the distal radius. Peripheral quantitative computed tomography (pQCT) can provide volumetric bone density data, as well as information on bone geometry, which makes it possible to establish finite element (FE) models of the distal radius from which bone strength and stiffness can be calculated. In this ...
Published on Dec 1, 2019in Bone4.36
Sophie Liabeuf20
Estimated H-index: 20
Keith P. McCullough24
Estimated H-index: 24
+ 10 AuthorsPhilipp A. Csomor
Abstract Background and objectives Chronic kidney disease (CKD) is commonly associated with mineral and bone metabolism disorders, but these are less frequently studied in non-dialysis CKD patients than in dialysis patients. We examined and described international variation in mineral and bone disease (MBD) markers and their treatment and target levels in Stage 3–5 CKD patients. Design, setting, participants, and measurements Prospective cohort study of 7658 adult patients with eGFR Results Over...
Published on Dec 1, 2019in Bone4.36
Stergios A. Polyzos31
Estimated H-index: 31
(A.U.Th.: Aristotle University of Thessaloniki),
Polyzois Makras20
Estimated H-index: 20
(Hellenic Air Force)
+ 1 AuthorsAthanasios D. Anastasilakis20
Estimated H-index: 20
Abstract Denosumab (Dmab), a monoclonal antibody against the receptor activator of nuclear factor-κB (RANK) ligand (RANKL) which substantially suppresses osteoclast activity, has been approved for the treatment of common metabolic bone diseases, including postmenopausal osteoporosis, male osteoporosis, and glucocorticoid-induced osteoporosis, in which the pathway of the RANK/RANKL/osteoprotegerin is dysregulated. However, the imbalance of RANKL/RANK/osteoprotegerin is also implicated in the path...
Published on Dec 1, 2019in Bone4.36
Saroj K. Sahoo3
Estimated H-index: 3
Priyanka Kushwaha12
Estimated H-index: 12
+ 8 AuthorsNobuaki Ito14
Estimated H-index: 14
Abstract Context The mechanism behind hypophosphatemia in the setting of neurofibromatosis type 1 (NF1) is not known. We describe a possible role of fibroblast growth factor 23 (FGF23) in the pathophysiology of hypophosphatemia in a patient with NF1. Case description A 34-year woman with NF1 presented with severe hypophosphatemia, osteomalacia, and elevated plasma FGF23. The patient had considerable improvement on replacement of oral phosphate. Two Ga68 DOTANOC PET-CT scans over a period of 2 ye...
Published on 2019in Bone4.36
A.W. Nielsen2
Estimated H-index: 2
(Aarhus University Hospital),
Rasmus Klose-Jensen1
Estimated H-index: 1
(Aarhus University Hospital)
+ 4 AuthorsEllen-Margrethe Hauge10
Estimated H-index: 10
(AU: Aarhus University)
Abstract Objective Age is the most important risk factor for osteoarthritis (OA). It is suggested that changes in subchondral bone and calcified cartilage may occur in early OA. Therefore, the aim was to investigate age-related changes in the femoral head composition. We hypothesise that the thickness of the subchondral bone plate decreases with age, while the thickness of the calcified cartilage increases with age as seen in early-stage OA. Methods Femoral heads from 29 women (20–74 years) and ...
Published on Nov 1, 2019in Bone4.36
Sun H. Peck6
Estimated H-index: 6
(UPenn: University of Pennsylvania),
John W. Tobias32
Estimated H-index: 32
(UPenn: University of Pennsylvania)
+ 4 AuthorsLachlan J. Smith19
Estimated H-index: 19
(UPenn: University of Pennsylvania)
Abstract Mucopolysaccharidosis (MPS) VII is a lysosomal storage disorder characterized by deficient activity of β-glucuronidase, leading to progressive accumulation of incompletely degraded heparan, dermatan, and chondroitin sulfate glycosaminoglycans (GAGs). Patients with MPS VII exhibit progressive skeletal deformity including kyphoscoliosis and joint dysplasia, which decrease quality of life and increase mortality. Previously, using the naturally-occurring canine model, we demonstrated that o...
Published on Nov 1, 2019in Bone4.36
Quan Zheng (Wannan Medical College), Xing-xing Li (Anhui Medical University)+ 5 AuthorsHongguang Xu6
Estimated H-index: 6
(Wannan Medical College)
Abstract End plate chondrocyte degeneration is a major cause of intervertebral disc degeneration. Mechanical biophysical forces, including intermittent cyclic mechanical tension (ICMT), exacerbate end plate chondrocyte degeneration. However, the underlying molecular mechanism of mechanical stretch-induced end plate chondrocyte degeneration is still unclear. This study sought to determine whether microRNAs (miRNAs) respond to mechanical stretch and play a role in regulating mechanically-induced e...