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Apoptosis
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#1Chengkui YangH-Index: 3
Last. Tao Yang
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#1Zhongjie YuH-Index: 1
Last. Peifeng LiH-Index: 26
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#2Johanna HuttunenH-Index: 3
Last. Kristiina M. HuttunenH-Index: 15
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#1Rohit SahaiH-Index: 1
Last. Kalyan MitraH-Index: 24
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#1Maria CosenzaH-Index: 8
#2Monica CivalleroH-Index: 7
Last. Samantha PozziH-Index: 25
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#1Qiang Ma (Chinese PLA General Hospital)H-Index: 8
#2Jing-Wei Li (Third Military Medical University)H-Index: 1
Last. Yundai Chen (Chinese PLA General Hospital)H-Index: 22
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RNase L is generally thought to play a key role in antiviral defenses. Although RNase L protein and mRNA are known to be highly expressed in myocardial tissue, there are few studies of the potential functions of RNase L in myocardial tissue. In this study, we tested the hypothesis that RNase L may be involved in the pathological process of cardiac ischemic injury. RNase L-overexpressing and RNase L knockdown H9c2 cell lines were subjected to the oxygen and glucose deprivation (OGD) model, and RN...
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#1Wei-Han Li (Peking Union Medical College)H-Index: 1
#2Ying-Lin Yang (Peking Union Medical College)H-Index: 2
Last. Guanhua Du (Peking Union Medical College)H-Index: 41
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It is reported that baicalein can activate PI3K/AKT pathway, inhibit caspase activation and reduce cerebral infarct volume in middle cerebral artery occlusion (MCAO) rats. However, a caspase-independent mechanism initiated by poly (ADP-ribose) polymerase-1 (PARP-1) activation has been reported to make more contribution to cells death after ischemic stroke. In the present study, we established a cerebral ischemia/reperfusion (I/R) rat model through middle cerebral artery occlusion following reper...
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#1Prashanthi Ramesh (UvA: University of Amsterdam)H-Index: 2
#2Jan Paul Medema (UvA: University of Amsterdam)H-Index: 55
Apoptosis is a form of programmed cell death that is essential for tissue homeostasis. De-regulation of the balance between proliferation and apoptosis contributes to tumor initiation. Particularly in the colon where apoptosis is a crucial process in intestinal turnover, inhibition of apoptosis facilitates transformation and tumor progression. The BCL-2 family of proteins are key regulators of apoptosis and have been implicated in colorectal cancer (CRC) initiation, progression and resistance to...
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#1Xianxian Cao (Capital Medical University)
#2Bin Li (Capital Medical University)
Last. Caixia Guo (Capital Medical University)H-Index: 5
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Soluble receptor for advanced glycation end-products (sRAGE), which exerts cardioprotective effect through inhibiting cardiomyocyte apoptosis and autophagy during ischemia/reperfusion (I/R) injury, is also known to enhance angiogenesis in post-ischemic reperfusion injury-critical limb ischemia (PIRI-CLI) mice. However, whether sRAGE protects the heart from myocardial I/R injury via promoting angiogenesis remains unclear. Myocardial model of I/R injury was conducted by left anterior descending (L...
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Top fields of study
Molecular biology
Apoptosis
Programmed cell death
Biology
Cell biology