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#1Halina BaranH-Index: 20
#2Carina KronsteinerH-Index: 1
Last. Berthold KepplingerH-Index: 9
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BACKGROUND/AIMS: Fluids of the human body such as serum, cerebrospinal fluid and saliva contain a wide variety of proteins. Because kynurenic acid (KYNA) has been detected in human saliva, we wondered if KYNA could be produced in saliva by KYNA-synthesising enzymes, namely the kynurenine aminotransferases KAT I, KAT II and KAT III. METHODS: Thirty samples of human saliva from control volunteers were investigated. KAT activity was measured in the presence of 1 mM pyruvate and 2 microM or 100 micr...
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#1Florian Lang (University of Tübingen)H-Index: 105
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1,25(OH)2D3 (1,25-dihydroxy-vitamin D3 = calcitriol) is a powerful regulator of mineral metabolism. The hormone increases calcium and phosphate plasma concentrations in part by stimulation of intestinal absorption and renal reabsorption of calcium and phosphate. It is primarily, but not exclusively, produced in the kidney. Renal 1,25(OH)2D3 formation is stimulated by calcium and phosphate deficiency and by parathyroid hormone which is up-regulated by hypocalcemia. 1,25(OH)2D3 formation is inhibi...
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#1Nina Lisofsky (MPG: Max Planck Society)H-Index: 6
#2Jürgen GallinatH-Index: 49
Last. Simone Kühn (MPG: Max Planck Society)H-Index: 42
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#1Georgios KogiasH-Index: 1
Last. Christian P. MüllerH-Index: 79
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BACKGROUND/AIMS: Swiprosin-1/ EF-hand domain 2 (EFhd2) is a Ca2+ sensor protein that plays an important role in the immune system. Its abundant expression in the brain, however, suggested also a role in neuronal circuits and behavior. METHODS: Here we review recent discoveries on the structure and molecular function, its role in immunity and its function in the brain regarding behavioral control and pathologies. RESULTS: While EFhd2 did not emerge as a vital protein for brain development, change...
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#1Silke WalterH-Index: 26
#1Silke WalterH-Index: 1
Last. Klaus FassbenderH-Index: 31
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BACKGROUND/AIMS: Multiple sclerosis (MS) is one of the most common autoimmune disorders of the central nervous system (CNS) and the leading cause of neurological disability among young adults in the Western world. We have previously shown that the acid sphingomyelinase plays an important role in the pathogenesis of experimental autoimmune encephalomyelitis (EAE), an animal model for multiple sclerosis. METHODS: We induced adoptively transferred EAE in wildtype and acid sphingomyelinase-deficient...
1 CitationsSource
#2Halina BaranH-Index: 20
Last. J. Reuss
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BACKGROUND/AIMS: Normal pressure hydrocephalus (NPH) is a potentially reversible neurological syndrome commonly characterized by gait disturbance, urinary incontinence, and dementia. Hydrocephalus e-vacuo (He-v) is also characterized by the occurrence of dementia but does not show gait disturbance or urinary incontinence and has no evident cerebrospinal fluid (CSF) pressure elevation. Kynurenic acid (KYNA), an endogenous metabolite of the L-kynurenine (L-KYN) pathway of L-tryptophan (L-TRP) degr...
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#1Ayan Mohamud YusufH-Index: 1
#1Mohamud Yusuf AH-Index: 1
Last. Dirk M. HermannH-Index: 1
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In this review, we summarize implications of the acid sphingomyelinase/ ceramide system in ischemic stroke. Acid sphingomyelinase catalyzes the formation of the bioactive sphingolipid ceramide which coalesces into membrane platforms and has a pivotal role in inflammation, cell signaling and death. Cerebral ischemia increases acid sphingomyelinase activity and elevates brain ceramide levels, which has been associated with the exacerbation of ischemic injury and deterioration of stroke outcome. In...
1 CitationsSource
#1Jun-Bin YinH-Index: 6
#2Ya-Cheng LuH-Index: 7
Last. Yun-Qing LiH-Index: 22
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#1Simone Kühn (MPG: Max Planck Society)H-Index: 42
#2Dimitrij KuglerH-Index: 2
Last. Jürgen GallinatH-Index: 49
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Background/Aims: It is a common concern in the research field and the community that habitual violent video gaming reduces empathy for pain in its players. However, previous fMRI studies have only compared habitual game players against control participants cross-sectionally. However the observed pattern of results may be due to a priori differences in people who become gamers and who not. In order to derive the causal conclusion that violent video game play causes desensitisation, longitudinal s...
2 CitationsSource
#1Ping QianH-Index: 3
#2Bo HuH-Index: 7
Last. Ruilin ShenH-Index: 6
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