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Addiction Biology
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#1Lucia Caffino (University of Milan)H-Index: 15
#2Francesca Mottarlini (University of Milan)H-Index: 4
Last. Judith R. Homberg (Radboud University Nijmegen Medical Centre)H-Index: 35
view all 7 authors...
Vulnerability to drug addiction relies on substantial individual differences. We previously demonstrated that serotonin transporter knockout (SERT(-/-) ) rats show increased cocaine intake and develop signs of compulsivity. However, the underlying neural mechanisms are not fully understood. Given the pivotal role of glutamate and prefrontal cortex in cocaine-seeking behavior, we sought to investigate the expression of proteins implicated in glutamate neurotransmission in the prefrontal cortex of...
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#1Anna S. Warden (University of Texas at Austin)H-Index: 5
#2Todd A. Triplett (University of Texas at Austin)H-Index: 2
Last. R. Dayne Mayfield (University of Texas at Austin)H-Index: 22
view all 11 authors...
Alcohol abuse induces changes in microglia morphology and immune function, but whether microglia initiate or simply amplify the harmful effects of alcohol exposure is still a matter of debate. Here, we determine microglia function in acute and voluntary drinking behaviors using a colony-stimulating factor 1 receptor inhibitor (PLX5622). We show that microglia depletion does not alter the sedative or hypnotic effects of acute intoxication. Microglia depletion also does not change the escalation o...
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#1Peng Liu (Xi'an Jiaotong University)H-Index: 7
#2Zheng Chu (Xi'an Jiaotong University)H-Index: 5
Last. Yong-hui Dang (Xi'an Jiaotong University)H-Index: 10
view all 6 authors...
Drug addiction is a recurrent, chronic brain disease. The existing treatment methods have limitations, such as poor adherence and inability to completely avoid relapse. Histidine triad nucleotide-binding protein 1 (HINT1) is involved in many neuropsychiatric diseases, such as schizophrenia, pain, and drug dependence. Studies have confirmed that there is a genetic link between HINT1 and addictions such as nicotine and cocaine. However, there is no research on the role of HINT1 protein in morphine...
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#1Andre T. Walcott (OHSU: Oregon Health & Science University)H-Index: 3
#2Andrey E. Ryabinin (OHSU: Oregon Health & Science University)H-Index: 39
Alcohol use disorder affects millions of people each year. Currently approved pharmacotherapies have limited success in treating this disorder. Evidence suggests that this lack of success is partly due to how these pharmacotherapies are tested in preclinical settings. The vast majority of preclinical studies assessing the effects of pharmacotherapies on alcohol or drug self-administration are done in individually housed animals. However, it is known that alcohol and drug intake are heavily influ...
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#1Victor Echeverry-Alzate (University of Picardie Jules Verne)H-Index: 8
#2Jérôme Jeanblanc (University of Picardie Jules Verne)H-Index: 6
Last. Mickaël Naassila (University of Picardie Jules Verne)H-Index: 24
view all 8 authors...
For several decades, studies conducted to evaluate the efficacy of RS(+/-)-Baclofen in the treatment of alcohol dependence yielded contrasting results. Human and animal studies recently questioned the use of the racemic drug in patients since a potential important role of the different enantiomers has been revealed with an efficacy thought to reside with the active R(+)-enantiomer. Here we conducted experiments in the postdependent rat model of alcohol dependence to compare the efficacy of R(+)-...
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#1Ofir Turel (SC: University of Southern California)H-Index: 28
#2Qinghua HeH-Index: 19
Last. Antoine Bechara (SC: University of Southern California)H-Index: 78
view all 4 authors...
Internet gaming disorder (IGD) is a concerning issue that requires further research. Here, we seek to examine its neural etiology with an emphasis on the role of the insula. To do so, we relied on the tripartite neurocognitive model of addictive behaviors as applied to IGD. We hypothesized that (a) video game cues will elicit stronger reward system activation and weaker prefrontal activation in gamers vs controls, (b) the IGD scores of gamers will be positively associated with activation of the ...
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#1Roger Hudson (UWO: University of Western Ontario)H-Index: 2
#2Matthew R. Green (UWO: University of Western Ontario)
Last. Steven R. Laviolette (UWO: University of Western Ontario)H-Index: 30
view all 8 authors...
Long-term tobacco dependence typically develops during adolescence and neurodevelopmental nicotine exposure is associated with affective disturbances that manifest as a variety of neuropsychiatric comorbidities in clinical and preclinical studies, including mood and anxiety-related disorders. The nucleus accumbens shell (NASh) is critically involved in regulating emotional processing, and both molecular and neuronal disturbances in this structure are associated with mood and anxiety-related path...
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#1Joseph Aloi (UNMC: University of Nebraska Medical Center)H-Index: 2
#2Karina Blair (Boys Town)H-Index: 25
Last. Abraham Killanin (Boys Town)H-Index: 2
view all 13 authors...
Two of the most commonly used substances by adolescents in the United States are cannabis and alcohol. Cannabis use disorder (CUD) and alcohol use disorder (AUD) are associated with impairments in decision-making processes. One mechanism for impaired decision-making in these individuals is thought to be an inability to adequately represent future events during decision-making. In the current study involving 112 adolescents, we used a comparative optimism task to examine the relationship between ...
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#1Birgit Kähler (UHH: University of Hamburg)H-Index: 1
#2Eva Romswinkel (UHH: University of Hamburg)H-Index: 1
Last. Fabio Morellini (UHH: University of Hamburg)H-Index: 18
view all 6 authors...
Several studies in humans and rodents suggest an association between impulsivity and activity of the stress response on the one hand and addiction vulnerability on the other. The neural cell adhesion molecule (NCAM) has been related to several neuropsychiatric disorders in humans. Constitutively NCAM-deficient (-/-) mice display enhanced novelty-induced behavior and hyperfunction of the hypothalamic-pituitary-adrenal axis. Here we hypothesize that NCAM deficiency causes an altered response to co...
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#1Alice V. Ely (Christiana Care Health System)H-Index: 8
#2Kanchana Jagannathan (UPenn: University of Pennsylvania)H-Index: 18
Last. Reagan R. Wetherill (UPenn: University of Pennsylvania)H-Index: 13
view all 6 authors...
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