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Journal of Biomedical Optics
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2.56
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6442
Papers 6515
1 page of 652 pages (6,515 results)
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#1Rupsa Datta (Morgridge Institute for Research)
#2Tiffany M. Heaster (Morgridge Institute for Research)H-Index: 3
Last. Melissa C. Skala (Morgridge Institute for Research)H-Index: 24
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Significance: Fluorescence lifetime imaging microscopy (FLIM) is a powerful technique to distinguish the unique molecular environment of fluorophores. FLIM measures the time a fluorophore remains in an excited state before emitting a photon, and detects molecular variations of fluorophores that are not apparent with spectral techniques alone. FLIM is sensitive to multiple biomedical processes including disease progression and drug efficacy. Aim: We provide an overview of FLIM principles, instrum...
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#1Eunwoo Park (Gwangju Institute of Science and Technology)
#2Yong-Jae Lee (Gwangju Institute of Science and Technology)
Last. Tae Joong Eom (Gwangju Institute of Science and Technology)H-Index: 12
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#1Renzhe BiH-Index: 7
Last. Malini OlivoH-Index: 41
view all 8 authors...
Significance: Noninvasive in vivo fast pulsatile blood flow measurement in deep tissue is important because the blood flow waveform is correlated with physiological parameters, such as blood pressure and elasticity of blood vessels. Compromised blood flow may cause diseases, such as stroke, foot ulcer, and myocardial ischemia. There is great clinical demand for a portable and cost-effective device for noninvasive pulsatile blood flow measurement. Aim: A diffuse-optics-based method, diffuse speck...
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#1Zeinab Hajjarian (Harvard University)H-Index: 11
#2Seemantini K. Nadkarni (Harvard University)H-Index: 18
Significance: The onset of several diseases is frequently marked with anomalous mechanical alteration of the affected tissue at the intersection of cells and their microenvironment. Therefore, mapping the micromechanical attributes of the tissues could enhance our understanding of the etiology of human disease, improve the diagnosis, and help stratify therapies that target these mechanical aberrations. Aim: We review the tremendous opportunities offered through using optics for imaging the micro...
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#1Xiaowei Zhao (Case Western Reserve University)H-Index: 1
#2Orhan Kilinc (Boston Children's Hospital)
Last. Andrew M. Rollins (Case Western Reserve University)H-Index: 45
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SIGNIFICANCE: Pulmonary vein isolation with catheter-based radiofrequency ablation (RFA) is carried out frequently to treat atrial fibrillation. However, RFA lesion creation is only guided by indirect information (e.g., temperature, impedance, and contact force), which may result in poor lesion quality (e.g., nontransmural) and can lead to reoccurrence or complications. AIM: The feasibility of guiding intracardiac RFA with an integrated polarization-sensitive optical coherence tomography (PSOCT)...
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Journal of Biomedical Optics editor-in-chief Brian W. Pogue outlines a revision of scope for the journal.
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#1Damon T. DePaoli (Laval University)H-Index: 1
#2Emile Lemoine (École Polytechnique de Montréal)H-Index: 1
Last. Daniel Côté (Laval University)H-Index: 30
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SIGNIFICANCE: Although the clinical potential for Raman spectroscopy (RS) has been anticipated for decades, it has only recently been used in neurosurgery. Still, few devices have succeeded in making their way into the operating room. With recent technological advancements, however, vibrational sensing is poised to be a revolutionary tool for neurosurgeons. AIM: We give a summary of neurosurgical workflows and key translational milestones of RS in clinical use and provide the optics and data sci...
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#1Kimberley S. Samkoe (Dartmouth College)H-Index: 22
#2Jonathan P. Celli (University of Massachusetts Boston)H-Index: 19
Last. Timothy C. Zhu (UPenn: University of Pennsylvania)H-Index: 37
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Guest Editors introduce the Special Section on Photodynamic Therapy for the Journal of Biomedical Optics, Volume 25, Issue 6.
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#1Monika Malak (University of Gothenburg)
#2Julie Grantham (University of Gothenburg)H-Index: 9
Last. Marica B. Ericson (University of Gothenburg)H-Index: 21
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SIGNIFICANCE: Research in tissue engineering and in vitro organ formation has recently intensified. To assess tissue morphology, the method of choice today is restricted primarily to histology. Thus novel tools are required to enable noninvasive, and preferably label-free, three-dimensional imaging that is more compatible with futuristic organ-on-a-chip models. AIM: We investigate the potential for using multiphoton microscopy (MPM) as a label-free in vitro approach to monitor calcium-induced ep...
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#1Achuth Nair (UH: University of Houston)H-Index: 6
#2Manmohan Singh (UH: University of Houston)H-Index: 15
Last. V Larin Kirill (UH: University of Houston)H-Index: 40
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Significance: It is generally agreed that the corneal mechanical properties are strongly linked to many eye diseases and could be used to assess disease progression and response to therapies. Elastography is the most notable method of assessing corneal mechanical properties, but it generally requires some type of external excitation to induce a measurable displacement in the tissue. Aim: We present Heartbeat Optical Coherence Elastography (Hb-OCE), a truly passive method that can measure the ela...
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Top fields of study
Optics
Optical coherence tomography
Nuclear magnetic resonance
Laser
Medicine